Phenotypes associated with this allele

• Allele Symbol: hubb
• Allele Name: hyper-unconjugated bilirubinemia
• Allele ID: MGI:1861101
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	hubb/hubb	involves: ICR	MGI:3833431

Genotype
MGI:3833431

hm1

• Allelic Composition: hubb/hubb
• Genetic Background: involves: ICR

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:8170 )

• mutant mice have higher than normal mortality through 6 weeks of age

behavior/neurological

abnormal maternal behavior ( J:8170 , J:96710 )

♀ • mutant mice nursed by homozygous females have increased mortality and reduced growth weights (J:8170)

♀ • immunocytochemistry shows high dihydroxyphenylacietic acid levels at early lactation in mutant mice, implicating low prolation levels as the cause of diminished maternal care (J:96710)

abnormal maternal nurturing ( J:8170 , J:96710 )

♀ (J:8170)

♀ (J:96710)

abnormal maternal grooming ( J:96710 )

♀

pup cannibalization ( J:96710 )

♀

endocrine/exocrine glands

small testis ( J:8170 )

♂

growth/size/body

inguinal hernia ( J:8170 )

abnormal postnatal growth/weight/body size ( J:8170 )

• reduced growth of rate offspring due to maternal neglect

• at 6 weeks of age mutant mice weighed less than normal mice

increased liver weight ( J:8170 )

• at 6 weeks of age compared to normal

increased spleen weight ( J:8170 )

• normal at 6 weeks of age but greater in weight compared to normal at 17 weeks of age

homeostasis/metabolism

abnormal circulating bilirubin level ( J:8170 )

• detected 24 hours postpartum

increased circulating bilirubin level ( J:8170 )

• there is a major increase in unconjugated serum bilirubin

liver/biliary system

increased liver weight ( J:8170 )

• at 6 weeks of age compared to normal

jaundice ( J:8170 )

• appears in young mice at about 24 hours postpartum, detected by a distinct orange coloration

reproductive system

small testis ( J:8170 )

♂

abnormal spermatogenesis ( J:8170 )

♂ • seminiferous tubules contain predominantly spermatogonial cells; only a few primary spermatocytes

♂ • secondary spermatocytes, spermatids, and spermatozoa are absent from the majority of seminiferous tubules

azoospermia ( J:8170 )

♂ • may be the result of a rise in scrotal temperature due to inguinal hernia

enlarged scrotum ( J:8170 )

♂ • due to inguinal hernia

male infertility ( J:8170 )

♂

pigmentation

abnormal coat/hair pigmentation ( J:8170 )

yellow coat color ( J:8170 )

• observed as hair appears but begins to disappear at weaning

• by 6 weeks of age coat color is indistinguishable from normal albino siblings

hematopoietic system

increased spleen weight ( J:8170 )

• normal at 6 weeks of age but greater in weight compared to normal at 17 weeks of age

increased hematocrit ( J:8170 )

• normal at 6 weeks of age but greater in weight compared to normal at 17 weeks of age

immune system

increased spleen weight ( J:8170 )

• normal at 6 weeks of age but greater in weight compared to normal at 17 weeks of age

integument

abnormal coat/hair pigmentation ( J:8170 )

yellow coat color ( J:8170 )

• observed as hair appears but begins to disappear at weaning

• by 6 weeks of age coat color is indistinguishable from normal albino siblings

cellular

azoospermia ( J:8170 )

♂ • may be the result of a rise in scrotal temperature due to inguinal hernia