Phenotypes associated with this allele

• Allele Symbol: Nhs^Xcat
• Allele Name: X-linked cataract
• Allele ID: MGI:1861111
• Summary: 3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Nhs^Xcat/Nhs^Xcat	involves: DBA/2 * T STOCK	MGI:3587738
ht2	Nhs^Xcat/Nhs^+	involves: DBA/2 * T STOCK	MGI:3587739
ot3	Nhs^Xcat/Y	involves: DBA/2 * T STOCK	MGI:3587737

Genotype
MGI:3587738

hm1

• Allelic Composition: Nhs^Xcat/Nhs^Xcat
• Genetic Background: involves: DBA/2 * T STOCK

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

vision/eye

abnormal lens morphology ( J:16467 )

♀ • in the first postnatal week, degeneration of the lens nucleus and cortical fibers continues

♀ • by the second postnatal week, lenses appear amorphous except at the epithelium and at the equitorial cortex

abnormal lens capsule morphology ( J:16467 )

♀ • at E15, lens material extrudes through minute defects in the capsule; also observed at subsequent ages

ruptured lens capsule ( J:16467 )

♀ • by P21, rupture of the lens capsule is seen in all mice

lens vacuoles ( J:16467 )

♀ • at E14, small vacuoles appear in the center of the developing lens

♀ • by E17 and E18, these vacuoles expand to form large cavities

abnormal lens fiber morphology ( J:16467 )

♀ • at E14, an irregular arrangement of round primary fibers is seen, in contrast to the enlongated fibers of control lenses

♀ • at E15, the primary fibers in the center of the lens contain larger vacuoles and show evidence of dissolution, but peripheral fibers appear normal

♀ • at E17-E18, vacuoles are seen in secondary lens fibers, indicating degeneration

♀ • by the first postnatal week, cytological architecture is no longer recognizable in the primary fibers

cataract ( J:10940 , J:16467 )

♀ (J:10940)

♀ (J:16467)

total cataract ( J:14118 )

♀ • total lens opacity

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
Nance-Horan syndrome		DOID:0060599	OMIM:302350	J:19674 , J:89306

Genotype
MGI:3587739

ht2

• Allelic Composition: Nhs^Xcat/Nhs⁺
• Genetic Background: involves: DBA/2 * T STOCK

vision/eye

cataract ( J:10940 , J:14118 , J:16467 )

♀ (J:10940)

♀ • variable expression ranging from totally opaque to totally clear lenses (J:14118)

♀ (J:16467)

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
Nance-Horan syndrome		DOID:0060599	OMIM:302350	J:19674 , J:89306

Genotype
MGI:3587737

ot3

• Allelic Composition: Nhs^Xcat/Y
• Genetic Background: involves: DBA/2 * T STOCK

vision/eye

abnormal lens morphology ( J:16467 )

♂ • in the first postnatal week, degeneration of the lens nucleus and cortical fibers continues

♂ • by the second postnatal week, lenses appear amorphous except at the epithelium and at the equitorial cortex

abnormal lens capsule morphology ( J:16467 )

♂ • at E15, lens material extrudes through minute defects in the capsule; also observed at subsequent ages

ruptured lens capsule ( J:16467 )

♂ • by P21, rupture of the lens capsule is seen in all mice

lens vacuoles ( J:16467 )

♂ • at E14, small vacuoles appear in the center of the developing lens

♂ • by E17 and E18, these vacuoles expand to form large cavities

abnormal lens fiber morphology ( J:16467 )

♂ • at E14, an irregular arrangement of round primary fibers is seen, in contrast to the elongated fibers of control lenses

♂ • at E15, the primary fibers in the center of the lens contain larger vacuoles and show evidence of dissolution, but peripheral fibers appear normal

♂ • at E17-E18, vacuoles are seen in secondary lens fibers, indicating degeneration

♂ • by the first postnatal week, cytological architecture is no longer recognizable in the primary fibers

cataract ( J:10940 , J:16467 )

♂ (J:10940)

♂ (J:16467)

total cataract ( J:14118 )

♂ • total lens opacity

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
Nance-Horan syndrome		DOID:0060599	OMIM:302350	J:19674 , J:89306