Phenotypes associated with this allele

• Allele Symbol: Il1r1^tm1Imx
• Allele Name: targeted mutation 1, Immunex Research and Development Corporation
• Allele ID: MGI:1861112
• Summary: 12 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Il1r1^tm1Imx/Il1r1^tm1Imx	B6.129S7-Il1r1^tm1Imx	MGI:5085871
hm2	Il1r1^tm1Imx/Il1r1^tm1Imx	B6.129S7-Il1r1^tm1Imx/J	MGI:4939274
hm3	Il1r1^tm1Imx/Il1r1^tm1Imx	involves: 129 * C57BL/6	MGI:2179471
hm4	Il1r1^tm1Imx/Il1r1^tm1Imx	involves: 129S7/SvEvBrd	MGI:3838333
hm5	Il1r1^tm1Imx/Il1r1^tm1Imx	involves: 129S7/SvEvBrd * C57BL/6	MGI:4939151
cx6	Apoe^tm1Unc/Apoe^tm1Unc Il1r1^tm1Imx/Il1r1^tm1Imx	B6.129-Il1r1^tm1Imx Apoe^tm1Unc	MGI:4939466
cx7	Tnfrsf1a^tm1Imx/Tnfrsf1a^tm1Imx Il1r1^tm1Imx/Il1r1^tm1Imx	B6;129S-Tnfrsf1a^tm1Imx Il1r1^tm1Imx/J	MGI:3580519
cx8	Il1r1^tm1Imx/Il1r1^tm1Imx Vsig4^tm1Gne/Vsig4^tm1Gne	B6.Cg-Il1r1^tm1Imx Vsig4^tm1Gne	MGI:6384866
cx9	Casp1^tm1Flv/Casp1^tm1Flv Casp4^del/Casp4^del Il1r1^tm1Imx/Il1r1^tm1Imx	involves: 129S2/SvPas * 129S7/SvEvBrd * C57BL/6	MGI:2179470
cx10	Aire^tm1.1Doi/Aire^tm1.1Doi Il1r1^tm1Imx/Il1r1^+	involves: 129S2/SvPas * 129S7/SvEvBrd * NOD	MGI:5428441
cx11	Aire^tm1.1Doi/Aire^tm1.1Doi Il1r1^tm1Imx/Il1r1^tm1Imx	involves: 129S2/SvPas * 129S7/SvEvBrd * NOD	MGI:5428442
cx12	Il1r1^tm1Imx/Il1r1^tm1Imx Tnfrsf1a^tm1Imx/Tnfrsf1a^tm1Imx	involves: 129S7/SvEvBrd * C57BL/6	MGI:3784419

Genotype
MGI:5085871

hm1

• Allelic Composition: Il1r1^tm1Imx/Il1r1^tm1Imx
• Genetic Background: B6.129S7-Il1r1^tm1Imx

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

immune system phenotype ( J:173245 )

N • mice co-housed with wild-type mice do not affect the susceptibility to induced colitis of wild-type mice

Genotype
MGI:4939274

hm2

• Allelic Composition: Il1r1^tm1Imx/Il1r1^tm1Imx
• Genetic Background: B6.129S7-Il1r1^tm1Imx/J

mortality/aging

increased susceptibility to bacterial infection induced morbidity/mortality ( J:125570 )

• following S. aureus infection

immune system

increased circulating interleukin-1 beta level ( J:125570 )

• 96 hours following S. aureus infection

decreased circulating interleukin-18 level ( J:125570 )

• 24 hours following S. aureus infection

increased circulating interleukin-18 level ( J:125570 )

• 96 hours following S. aureus infection

decreased circulating interleukin-6 level ( J:125570 )

• 4 and 24 hours following S. aureus infection

decreased interleukin-6 secretion ( J:125570 , J:148779 )

• in spleen cells stimulated with formalin-killed S. aureus infection for 48 hours (J:125570)

• within wound fluids on days 1, 3, 5, 10, and 14 of wound healing (J:148779)

decreased tumor necrosis factor secretion ( J:125570 )

• in spleen cells stimulated with formalin-killed S. aureus infection

increased susceptibility to induced arthritis ( J:125570 )

• following S. aureus infection

increased susceptibility to bacterial infection ( J:125570 )

• following S. aureus infection, mice exhibit severe septicemia, increased weight loss, increased frequency and severity of arthritis, increased bacterial load, and decreased survival compared with wild-type mice

increased susceptibility to bacterial infection induced morbidity/mortality ( J:125570 )

• following S. aureus infection

sepsis ( J:125570 )

• following S. aureus infection

homeostasis/metabolism

abnormal vascular wound healing ( J:107324 )

• following carotid ligation, mice exhibit a 19-fold reduction in neointima/media area, 3.4-fold increase in lumen area, and decrease in total vessel area compared with wild-type mice

• neointima formation following carotid ligation is disrupted to a greater extent when null mice transplanted with null bone marrow compared when null mice are receive wild-type bone marrow or wild-type mice receive null bone marrow

increased circulating insulin level ( J:108634 )

• 2-fold in 9 and 11 month old mice

increased circulating insulin-like growth factor I level ( J:108634 )

• in older mice

increased circulating leptin level ( J:108634 )

• 2-fold in 9 and 11 month old mice

increased circulating interleukin-1 beta level ( J:125570 )

• 96 hours following S. aureus infection

decreased circulating interleukin-18 level ( J:125570 )

• 24 hours following S. aureus infection

increased circulating interleukin-18 level ( J:125570 )

• 96 hours following S. aureus infection

decreased circulating interleukin-6 level ( J:125570 )

• 4 and 24 hours following S. aureus infection

increased respiratory quotient ( J:108634 )

• during the first half of the dark cycle

impaired glucose tolerance ( J:108634 )

• following glucose challenge, older mice exhibit impaired plasma glucose elimination compared with wild-type mice

insulin resistance ( J:108634 )

• in older mice

decreased transforming growth factor beta level ( J:148779 )

• within wound fluids on day 1 of wound healing

decreased response to leptin ( J:108634 )

• preobese mice exhibit mild leptin resistance compared with wild-type mice

enhanced wound healing ( J:148779 )

• after wound healing, mice exhibit decreased scar width and depth compared with wild-type mice

• deep tissue wounds exhibit 3-fold less fibrosis compared to in wild-type mice

• however, mice exhibit normal cellular infiltration and tensile strength of skin wounds

growth/size/body

increased body mass index ( J:108634 )

• in older mice

abnormal lean body mass ( J:108634 )

• older mice exhibit a decrease in percentage lean body mass but an increase in absolute lean body mass compared with wild-type mice

weight loss ( J:125570 )

• following S. aureus infection

increased body weight ( J:108634 )

• after 5 to 6 months

increased body length ( J:108634 )

• in older mice

increased susceptibility to age related obesity ( J:108634 )

increased growth rate ( J:108634 )

• in older mice

increased liver weight ( J:108634 )

• in older mice

adipose tissue

increased total body fat amount ( J:108634 )

• 2-fold at 9 months of age

• however, mice exhibit normal body fat at 4 months of age

increased gonadal fat pad weight ( J:108634 )

• in older mice

increased inguinal fat pad weight ( J:108634 )

• in older mice

increased mesenteric fat pad weight ( J:108634 )

• in older mice

increased retroperitoneal fat pad weight ( J:108634 )

• in older mice

increased abdominal fat pad weight ( J:108634 )

• at 19 months, intra-abdominal fat mass is increased 1.5- to 1.7-fold compared with wild-type mice

increased percent body fat/body weight ( J:108634 )

• in older mice

skeleton

increased susceptibility to induced arthritis ( J:125570 )

• following S. aureus infection

behavior/neurological

enhanced contextual conditioning behavior ( J:150445 )

decreased anxiety-related response ( J:150445 )

• mice exhibit reduced latency to drink in a novelty-induced hypophagia test compared with wild-type mice

• mice spend more time in the open arms of an elevated plus maze compared with wild-type mice

• mice exhibit increased latency to enter into the dark chamber in a light/dark test compared with wild-type mice

decreased locomotor activity ( J:108634 )

• during the dark phase at 4 months

liver/biliary system

increased liver weight ( J:108634 )

• in older mice

cardiovascular system

abnormal vascular wound healing ( J:107324 )

• following carotid ligation, mice exhibit a 19-fold reduction in neointima/media area, 3.4-fold increase in lumen area, and decrease in total vessel area compared with wild-type mice

• neointima formation following carotid ligation is disrupted to a greater extent when null mice transplanted with null bone marrow compared when null mice are receive wild-type bone marrow or wild-type mice receive null bone marrow

nervous system

abnormal nervous system electrophysiology ( J:145169 )

• following administration of kainate, Purkinje cells fail to exhibit an increase in firing rate unlike wild-type cells

Genotype
MGI:2179471

hm3

• Allelic Composition: Il1r1^tm1Imx/Il1r1^tm1Imx
• Genetic Background: involves: 129 * C57BL/6

homeostasis/metabolism

decreased circulating interleukin-6 level ( J:43088 )

• no IL-6 is detected in sera of mice injected with IL-1alpha

immune system

decreased circulating interleukin-6 level ( J:43088 )

• no IL-6 is detected in sera of mice injected with IL-1alpha

osteomyelitis ( J:58851 )

• osteolytic lesions of molars are significantly larger in these mice 2 weeks after bacterial inoculation of the dental pulp

• the osteolytic lesions continue to be larger for at least 38 days post inoculation

increased susceptibility to bacterial infection ( J:58851 )

• mice have 3 log greater bacterial penetration of the dental pulp eight days after bacterial innoculation

skeleton

dental pulp necrosis ( J:58851 )

• mice have significantly higher necrosis scores of the dental pulp seven days after bacterial inoculation

• complete necrosis of the dental pulp is observed by 21 days after inoculation compared to control mice that still have intact dental pulp at 38 days post-innoculation

osteomyelitis ( J:58851 )

• osteolytic lesions of molars are significantly larger in these mice 2 weeks after bacterial inoculation of the dental pulp

• the osteolytic lesions continue to be larger for at least 38 days post inoculation

increased bone resorption ( J:58851 )

• there is significantly more osteoclastogenesis that occurs in molars between 7 and 21 days after bacterial infection of the dental pulp

• osteoclast activity of the molars is 2-fold higher than in wild-types 7 days after bacterial inoculation

craniofacial

dental pulp necrosis ( J:58851 )

• mice have significantly higher necrosis scores of the dental pulp seven days after bacterial inoculation

• complete necrosis of the dental pulp is observed by 21 days after inoculation compared to control mice that still have intact dental pulp at 38 days post-innoculation

growth/size/body

dental pulp necrosis ( J:58851 )

• mice have significantly higher necrosis scores of the dental pulp seven days after bacterial inoculation

• complete necrosis of the dental pulp is observed by 21 days after inoculation compared to control mice that still have intact dental pulp at 38 days post-innoculation

Genotype
MGI:3838333

hm4

• Allelic Composition: Il1r1^tm1Imx/Il1r1^tm1Imx
• Genetic Background: involves: 129S7/SvEvBrd

craniofacial

delayed tooth eruption ( J:103141 )

• mice exhibit delayed eruption of mandibular and maxillary incisors and molars compared with wild-type mice

immune system

abnormal neutrophil physiology ( J:113110 )

• neutrophile response to monosodium urate injected into the peritoneal cavity is reduced 85% relative to controls

hematopoietic system

abnormal neutrophil physiology ( J:113110 )

• neutrophile response to monosodium urate injected into the peritoneal cavity is reduced 85% relative to controls

growth/size/body

delayed tooth eruption ( J:103141 )

• mice exhibit delayed eruption of mandibular and maxillary incisors and molars compared with wild-type mice

skeleton

delayed tooth eruption ( J:103141 )

• mice exhibit delayed eruption of mandibular and maxillary incisors and molars compared with wild-type mice

Genotype
MGI:4939151

hm5

• Allelic Composition: Il1r1^tm1Imx/Il1r1^tm1Imx
• Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

homeostasis/metabolism

decreased circulating creatinine level ( J:112999 )

• following ischemic/reperfusion injury, mice exhibit reduced serum creatinine levels at 48 and 72 hours compared with wild-type mice

decreased blood urea nitrogen level ( J:112999 )

• following ischemic/reperfusion injury, mice exhibit reduced blood urea nitrogen levels at 48 and 72 hours compared with wild-type mice

abnormal response/metabolism to endogenous compounds ( J:112148 )

• mice treated with IL1b, either intraperitoneally or intracerebroventricularly, fail to exhibit a decrease in social exploration, immobility, decrease in body weight, or reduced food intake compared with similarly treated wild-type mice

• pretreatment with TNFbp attenuates depressive effect of LPS unlike in similarly treated wild-type mice

• however, behavioral response to LPS treatment is normal

decreased susceptibility to kidney reperfusion injury ( J:112999 )

• following ischemic/reperfusion injury, mice exhibit reduced blood urea nitrogen and creatinine levels at 48 and 72 hours with reduced polymorphonuclear leukocyte infiltration compared with wild-type mice

• however, tubular damage is normal

immune system

abnormal neutrophil physiology ( J:112999 )

• following ischemic/reperfusion injury, mice exhibit reduced polymorphonuclear leukocyte infiltration compared with wild-type mice

decreased susceptibility to experimental autoimmune uveoretinitis ( J:115094 )

• following reverse passive Arthus reaction to induce uveitis, mice exhibit reduced cellular infiltration into the anterior and posterior segments compared with wild-type mice

renal/urinary system

decreased susceptibility to kidney reperfusion injury ( J:112999 )

• following ischemic/reperfusion injury, mice exhibit reduced blood urea nitrogen and creatinine levels at 48 and 72 hours with reduced polymorphonuclear leukocyte infiltration compared with wild-type mice

• however, tubular damage is normal

growth/size/body

increased body weight ( J:112148 )

• in some experiments

hematopoietic system

abnormal neutrophil physiology ( J:112999 )

• following ischemic/reperfusion injury, mice exhibit reduced polymorphonuclear leukocyte infiltration compared with wild-type mice

Genotype
MGI:4939466

cx6

• Allelic Composition: Apoe^tm1Unc/Apoe^tm1Unc; Il1r1^tm1Imx/Il1r1^tm1Imx
• Genetic Background: B6.129-Il1r1^tm1Imx Apoe^tm1Unc

cardiovascular system

decreased susceptibility to atherosclerosis ( J:148173 )

• when fed a Western diet with high cholate, but not when fed standard chow or a Western diet

• mice receiving Apoe^tm1Unc bone marrow develop 1.9-fold smaller lesions compared with similarly treated Apoe^tm1Unc homozygotes

decreased systemic arterial blood pressure ( J:148173 )

• when fed either a Western diet or a Western diet with high cholate compared with similarly treated Apoe^tm1Unc homozygotes

abnormal blood vessel physiology ( J:148173 )

• when fed either a Western diet with high cholate, mice exhibit a greater active pressure-diameter response compared with similarly treated Apoe^tm1Unc homozygotes

increased vasoconstriction ( J:148173 )

• when fed either a Western diet with high cholate, mice exhibit greater constriction in response to sensitivity to L-NAME treatment compared with similarly treated Apoe^tm1Unc homozygotes

increased vasodilation ( J:148173 )

• when fed either a Western diet or a Western diet with high cholate, mice exhibit greater vasodilator sensitivity to acetyl choline compared with similarly treated Apoe^tm1Unc homozygotes

homeostasis/metabolism

decreased circulating interleukin-6 level ( J:148173 )

• when fed either a Western diet compared with similarly treated Apoe^tm1Unc homozygotes

immune system

decreased circulating interleukin-6 level ( J:148173 )

• when fed either a Western diet compared with similarly treated Apoe^tm1Unc homozygotes

muscle

increased vasoconstriction ( J:148173 )

• when fed either a Western diet with high cholate, mice exhibit greater constriction in response to sensitivity to L-NAME treatment compared with similarly treated Apoe^tm1Unc homozygotes

increased vasodilation ( J:148173 )

• when fed either a Western diet or a Western diet with high cholate, mice exhibit greater vasodilator sensitivity to acetyl choline compared with similarly treated Apoe^tm1Unc homozygotes

Genotype
MGI:3580519

cx7

• Allelic Composition: Tnfrsf1a^tm1Imx/Tnfrsf1a^tm1Imx; Il1r1^tm1Imx/Il1r1^tm1Imx
• Genetic Background: B6;129S-Tnfrsf1a^tm1Imx Il1r1^tm1Imx/J

behavior/neurological

abnormal sleep pattern ( J:137505 )

• during the last 6 hours of the dark period, mice exhibit increased awake time and less non-REM sleep compared with wild-type mice wild-type mice

• during the light period, mice exhibit fewer bouts of REM sleep compared with wild-type mice

• following sleep deprivation, mice fail to exhibit REM sleep rebound unlike wild-type mice and exhibit more time awake and less time in non-REM sleep during the first 6 hours of dark period compared with wild-type mice

• however, the length of REM sleep bouts is normal

homeostasis/metabolism

abnormal circadian temperature homeostasis ( J:137505 )

• brain temperature during the dark phase is higher than in wild-type mice

• mice exhibit lower brain temperature during the first 6 hours following sleep deprivation compared with wild-type mice

nervous system

abnormal brain wave pattern ( J:137505 )

• mice exhibit a greater contribution of slower frequencies to the total power of the non-REM sleep power spectra, measured by electrocorticogram, compared with wild-type mice

• theta power contributes less to total power compared to in wild-type mice

• following sleep deprivation, mice exhibit higher delta power compared with wild-type mice

Genotype
MGI:6384866

cx8

• Allelic Composition: Il1r1^tm1Imx/Il1r1^tm1Imx; Vsig4^tm1Gne/Vsig4^tm1Gne
• Genetic Background: B6.Cg-Il1r1^tm1Imx Vsig4^tm1Gne

immune system

increased susceptibility to induced colitis ( J:281762 )

• DSS-treated mice exhibit more severe colitis compared with wild-type mice and Vsig4^tm1Gne homozygotes

decreased T helper 1 cell number ( J:281762 )

• in MOG35-55 treated mice

decreased T-helper 17 cell number ( J:281762 )

• in MOG35-55 treated mice

decreased susceptibility to experimental autoimmune encephalomyelitis ( J:281762 )

• MOG35-55 treated mice exhibit delayed onset and reduced clinical score, reduced leukocyte spinal cord infiltration, and decreased TH1 and TH17 cells in the spinal cord and spleen compared with wild-type mice and Vsig4^tm1Gne homozygotes

digestive/alimentary system

increased susceptibility to induced colitis ( J:281762 )

• DSS-treated mice exhibit more severe colitis compared with wild-type mice and Vsig4^tm1Gne homozygotes

hematopoietic system

decreased T helper 1 cell number ( J:281762 )

• in MOG35-55 treated mice

decreased T-helper 17 cell number ( J:281762 )

• in MOG35-55 treated mice

Genotype
MGI:2179470

cx9

• Allelic Composition: Casp1^tm1Flv/Casp1^tm1Flv; Casp4^del/Casp4^del; Il1r1^tm1Imx/Il1r1^tm1Imx
• Genetic Background: involves: 129S2/SvPas * 129S7/SvEvBrd * C57BL/6

immune system

decreased susceptibility to endotoxin shock ( J:43088 )

• resistance to endotoxin shock induced by high dose lipopolysaccharide (LPS)

Genotype
MGI:5428441

cx10

• Allelic Composition: Aire^tm1.1Doi/Aire^tm1.1Doi; Il1r1^tm1Imx/Il1r1⁺
• Genetic Background: involves: 129S2/SvPas * 129S7/SvEvBrd * NOD

vision/eye

lacrimal gland inflammation ( J:163691 )

• inflammation damages the tear-secreting acinar cells and interlobular septa

keratoconjunctivitis ( J:163691 )

cornea opacity ( J:163691 )

• progresses from desiccation and keratinization of the ocular surface

abnormal ocular surface morphology ( J:163691 )

• desiccation and keratinization of the ocular surface

• ocular surface epitheliopathy

abnormal lacrimal gland morphology ( J:163691 )

• inflammation damages the tear-secreting acinar cells and interlobular septa

abnormal conjunctiva goblet cell morphology ( J:163691 )

• mice exhibit an increase in acidified conjunctival goblet cells compared with wild-type mice

• however, the total number of goblet cells is normal

abnormal cornea epithelium morphology ( J:163691 )

• ocular mucosal epithelia metaplasia

• squamous metaplasia

dry eyes ( J:163691 )

endocrine/exocrine glands

abnormal lacrimal gland morphology ( J:163691 )

• inflammation damages the tear-secreting acinar cells and interlobular septa

lacrimal gland inflammation ( J:163691 )

• inflammation damages the tear-secreting acinar cells and interlobular septa

immune system

lacrimal gland inflammation ( J:163691 )

• inflammation damages the tear-secreting acinar cells and interlobular septa

keratoconjunctivitis ( J:163691 )

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
Sjogren's syndrome		DOID:12894	OMIM:270150	J:163691

Genotype
MGI:5428442

cx11

• Allelic Composition: Aire^tm1.1Doi/Aire^tm1.1Doi; Il1r1^tm1Imx/Il1r1^tm1Imx
• Genetic Background: involves: 129S2/SvPas * 129S7/SvEvBrd * NOD

vision/eye

lacrimal gland inflammation ( J:163691 )

• mostly CD4+ T cells

keratoconjunctivitis ( J:163691 )

abnormal conjunctiva goblet cell morphology ( J:163691 )

• mice exhibit an increase in acidified conjunctival goblet cells compared with wild-type mice that is not as severe as in Aire^tm1.1Doi homozygotes

• however, the total number of goblet cells is normal

abnormal cornea epithelium morphology ( J:163691 )

• mice exhibit ocular mucosal epithelia metaplasia and ocular surface epitheliopathy that is not as severe as in Aire^tm1.1Doi homozygotes

cornea opacity ( J:163691 )

• progresses from desiccation and keratinization of the ocular surface

dry eyes ( J:163691 )

immune system

lacrimal gland inflammation ( J:163691 )

• mostly CD4+ T cells

keratoconjunctivitis ( J:163691 )

endocrine/exocrine glands

lacrimal gland inflammation ( J:163691 )

• mostly CD4+ T cells

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
Sjogren's syndrome		DOID:12894	OMIM:270150	J:163691

Genotype
MGI:3784419

cx12

• Allelic Composition: Il1r1^tm1Imx/Il1r1^tm1Imx; Tnfrsf1a^tm1Imx/Tnfrsf1a^tm1Imx
• Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

immune system

impaired neutrophil recruitment ( J:126652 )

• lungs infected with E. coli have decreased amounts of neutrophils that emigrate from the alveolar septae

• neutrophil numbers in circulation or sequestered within the alveolar septae are similar to wild-type

abnormal chemokine level ( J:126652 )

• there is 2-fold less levels of Cxcl1 (KC) found in the bronchoalveolar lavage fluid of lungs infected with E. coli compared to infected wild-type mice

decreased interleukin-6 secretion ( J:115094 )

• into the aqueous humor following induction of uveitis

decreased susceptibility to experimental autoimmune uveoretinitis ( J:115094 )

• following reverse passive Arthus reaction to induce uveitis, mice exhibit reduced cellular infiltration into the anterior and posterior segments and IL6 secretion into the aqueous humor compared with wild-type mice

osteomyelitis ( J:58851 )

• osteolytic lesions of molars are larger in these mice 2 weeks after bacterial inoculation of the dental pulp compared to either wild-type controls or to homozygotes that are null for just one gene

• the osteolytic lesions continue to be larger for at least 38 days after inoculation

lung inflammation ( J:126652 )

• patchy pulmonary inflammation occurs spontaneously in about 2/3^rd of mice

• infiltrates contain mixed populations of leukocytes and are localized to the pleura, subpleura alveoli, and perivascular tissue

• eosinophilic crystalline deposits are found in the alveolar air spaces of inflamed areas

interstitial pneumonia ( J:126652 )

• lungs with pneumonia induced by E. coli inoculation have less neutrophil migration into the alveolar air spaces and less accumulation of extravascular plasma

increased susceptibility to bacterial infection ( J:58851 )

• mice have 4 log greater bacterial penetration of the dental pulp eight days after experimental bacterial infection

skeleton

dental pulp necrosis ( J:58851 )

• mice have significantly higher necrosis scores of the dental pulp seven days after bacterial inoculation

• complete necrosis of the dental pulp is observed by 7 days after bacterial inoculation compared to control mice that still have intact dental pulp at 38 days post-innoculation

osteomyelitis ( J:58851 )

• osteolytic lesions of molars are larger in these mice 2 weeks after bacterial inoculation of the dental pulp compared to either wild-type controls or to homozygotes that are null for just one gene

• the osteolytic lesions continue to be larger for at least 38 days after inoculation

increased bone resorption ( J:58851 )

• there is significantly more osteoclastogenesis that occurs in molars between 7 and 21 days after bacterial infection of the dental pulp

• osteoclast activity of the molars is 5-fold higher than in wild-types 7 days after bacterial inoculation

respiratory system

lung inflammation ( J:126652 )

• patchy pulmonary inflammation occurs spontaneously in about 2/3^rd of mice

• infiltrates contain mixed populations of leukocytes and are localized to the pleura, subpleura alveoli, and perivascular tissue

• eosinophilic crystalline deposits are found in the alveolar air spaces of inflamed areas

interstitial pneumonia ( J:126652 )

• lungs with pneumonia induced by E. coli inoculation have less neutrophil migration into the alveolar air spaces and less accumulation of extravascular plasma

homeostasis/metabolism

abnormal chemokine level ( J:126652 )

• there is 2-fold less levels of Cxcl1 (KC) found in the bronchoalveolar lavage fluid of lungs infected with E. coli compared to infected wild-type mice

hematopoietic system

impaired neutrophil recruitment ( J:126652 )

• lungs infected with E. coli have decreased amounts of neutrophils that emigrate from the alveolar septae

• neutrophil numbers in circulation or sequestered within the alveolar septae are similar to wild-type

craniofacial

dental pulp necrosis ( J:58851 )

• mice have significantly higher necrosis scores of the dental pulp seven days after bacterial inoculation

• complete necrosis of the dental pulp is observed by 7 days after bacterial inoculation compared to control mice that still have intact dental pulp at 38 days post-innoculation

growth/size/body

dental pulp necrosis ( J:58851 )

• mice have significantly higher necrosis scores of the dental pulp seven days after bacterial inoculation

• complete necrosis of the dental pulp is observed by 7 days after bacterial inoculation compared to control mice that still have intact dental pulp at 38 days post-innoculation