Phenotypes associated with this allele

• Allele Symbol: Em
• Allele Name: Emory cataract
• Allele ID: MGI:1861119
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
ot1	Em/?	CFW-Em	MGI:3800884

Genotype
MGI:3800884

ot1

• Allelic Composition: Em/?
• Genetic Background: CFW-Em

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

vision/eye

cataract ( J:6825 , J:7009 , J:24254 , J:79371 )

• lens opacities appear as early as 6 to 8 months in mutant mice and progress to a dense opaque central zone, with a shrunken appearance and loss of wet and dry weight of the lens mice exhibit bilateral cataracts (J:6825)

• cataracts development is associated with the conversion of soluble to insoluble proteins, with lower total protein and lower glutathione than in wild-type mice (J:7009)

• severity of cataracts developed is decreased in mice fed a calorie restricted diet (J:24254)

• after 6 months of age, female mice develop more severe cataracts than male mice (J:79371)