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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		In(15)4H
inversion, Chr 15, Harwell 4
MGI:1861120
Summary 4 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		In(15)4H/In(15)4H C3H/HeH-In(15)4H MGI:3768919
hm2
 		In(15)4H/In(15)4H involves: C3H/HeH MGI:3815542
ht3
 		In(15)4H/+ C3H/HeH-In(15)4H MGI:3768918
ht4
 		In(15)4H/+ involves: C3H/HeH MGI:3815543


Genotype
MGI:3768919
hm1
Allelic
Composition		 In(15)4H/In(15)4H
Genetic
Background		 C3H/HeH-In(15)4H
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
In(15)4H mutation (1 available); any In(15)4H mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
growth/size/body
bushy muzzle ( J:14236 )
broad head ( J:14236 )
• flatter, broader head
flat head ( J:14236 )
• flatter, broader head
hairy ears ( J:14236 )
• very hairy ears; ears are covered with a long hair on both the outer and inner surfaces
decreased body size ( J:103253 )
decreased body weight ( J:14236 )
• adult homozygotes weigh about 20% less than heterozygotes

hearing/vestibular/ear
hairy ears ( J:14236 )
• very hairy ears; ears are covered with a long hair on both the outer and inner surfaces

vision/eye
eyelids open at birth ( J:14236 , J:103253 )
• homozygotes often have open eyes at birth (J:14236)

reproductive system
decreased litter size ( J:14236 )
• smaller litter size when homozygous mice are mated

craniofacial
broad head ( J:14236 )
• flatter, broader head
flat head ( J:14236 )
• flatter, broader head
hairy ears ( J:14236 )
• very hairy ears; ears are covered with a long hair on both the outer and inner surfaces

integument
excessive hair ( J:14236 , J:103253 )
• very hairy ears; ears are covered with a long hair on both the outer and inner surfaces (J:14236)
• bushy muzzle (J:14236)
• homozygotes are slightly hairier than heterozygotes (J:14236)
hairy ears ( J:14236 )
• very hairy ears; ears are covered with a long hair on both the outer and inner surfaces




Genotype
MGI:3815542
hm2
Allelic
Composition		 In(15)4H/In(15)4H
Genetic
Background		 involves: C3H/HeH
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
In(15)4H mutation (1 available); any In(15)4H mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
growth/size/body
bushy muzzle ( J:141036 )
• long pelage type hairs around the muzzle
broad head ( J:141036 )
• mice exhibit a flatter and wider head than wild-type mice
flat head ( J:141036 )
• mice exhibit a flatter and wider head than wild-type mice
hairy ears ( J:141036 )
• long pelage type hairs on both surfaces of the pinnae
decreased body size ( J:141036 )

hearing/vestibular/ear
hairy ears ( J:141036 )
• long pelage type hairs on both surfaces of the pinnae

craniofacial
bushy muzzle ( J:141036 )
• long pelage type hairs around the muzzle
broad head ( J:141036 )
• mice exhibit a flatter and wider head than wild-type mice
flat head ( J:141036 )
• mice exhibit a flatter and wider head than wild-type mice
hairy ears ( J:141036 )
• long pelage type hairs on both surfaces of the pinnae

vision/eye

skeleton
abnormal spine curvature ( J:141036 )
• mice have a curved back compared to wild-type mice

integument
excessive hair ( J:141036 )
• mice exhibit hypertrichosis with long pelage type hairs on both surfaces of the pinnae and around the muzzle
bushy muzzle ( J:141036 )
• long pelage type hairs around the muzzle
hairy ears ( J:141036 )
• long pelage type hairs on both surfaces of the pinnae
abnormal vibrissa follicle morphology ( J:141036 )
• vibrissa follicles are fewer in number and more sparsely spaced than in wild-type mice

Mouse Models of Human Disease
 DO ID OMIM ID(s) Ref(s)
Ambras type hypertrichosis universalis congenita DOID:0111060 OMIM:145701
 J:141036




Genotype
MGI:3768918
ht3
Allelic
Composition		 In(15)4H/+
Genetic
Background		 C3H/HeH-In(15)4H
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
In(15)4H mutation (1 available); any In(15)4H mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
integument
excessive hair ( J:14236 , J:103253 )
• very hairy ears; ears are covered with a long hair on both the outer and inner surfaces (J:14236)
• bushy muzzle (J:14236)
hairy ears ( J:14236 )
• very hairy ears; ears are covered with a long hair on both the outer and inner surfaces

craniofacial
hairy ears ( J:14236 )
• very hairy ears; ears are covered with a long hair on both the outer and inner surfaces

growth/size/body
bushy muzzle ( J:14236 )
hairy ears ( J:14236 )
• very hairy ears; ears are covered with a long hair on both the outer and inner surfaces

hearing/vestibular/ear
hairy ears ( J:14236 )
• very hairy ears; ears are covered with a long hair on both the outer and inner surfaces




Genotype
MGI:3815543
ht4
Allelic
Composition		 In(15)4H/+
Genetic
Background		 involves: C3H/HeH
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
In(15)4H mutation (1 available); any In(15)4H mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
integument
abnormal coat/ hair morphology ( J:141036 )
• mice exhibit longer straight hairs on their muzzle than in wild-type mice
excessive hair ( J:141036 )
• mice exhibit hypertrichosis with long pelage type hairs on both surfaces of the pinnae and around the muzzle
bushy muzzle ( J:141036 )
• long pelage type hairs around the muzzle
hairy ears ( J:141036 , J:181531 )
• long pelage type hairs on both surfaces of the pinnae (J:141036)
• hairy ears (J:181531)
abnormal vibrissa follicle morphology ( J:141036 )
• vibrissa follicles are fewer in number and more sparsely spaced than in wild-type mice

craniofacial
bushy muzzle ( J:141036 )
• long pelage type hairs around the muzzle
hairy ears ( J:141036 , J:181531 )
• long pelage type hairs on both surfaces of the pinnae (J:141036)
• hairy ears (J:181531)

hearing/vestibular/ear
hairy ears ( J:141036 , J:181531 )
• long pelage type hairs on both surfaces of the pinnae (J:141036)
• hairy ears (J:181531)

growth/size/body
bushy muzzle ( J:141036 )
• long pelage type hairs around the muzzle
hairy ears ( J:141036 , J:181531 )
• long pelage type hairs on both surfaces of the pinnae (J:141036)
• hairy ears (J:181531)

Mouse Models of Human Disease
 DO ID OMIM ID(s) Ref(s)
Ambras type hypertrichosis universalis congenita DOID:0111060 OMIM:145701
 J:141036




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory