All Phenotypes Med1<tm1Jkr> MGI Mouse

embryonic lethality during organogenesis, complete penetrance ( J:62272 )

• at E11.5, most homozygotes are still viable; however, a small number of embryos are either moribund, dead or degenerating

• no homozygous embryos are detected at E12.5 or beyond

abnormal cardiovascular system morphology ( J:74328 )

dilated liver sinusoidal space ( J:74328 )

• at E11.5, mutant livers show significantly dilated sinusoids

abnormal placenta vasculature ( J:62272 , J:74328 )

• at E11.5, homozygotes display significant differences in fetal and maternal vascular channels; vascular channels are scant and contain few erythrocytes (J:62272)

• at E11.5, mutant placentas fail to develop a complex capillary network; however, reduced placental angiogenesis is in marked contrast with the excessive systemic vascularization observed in hyperemic mutant embryos (J:74328)

abnormal placental labyrinth vasculature morphology ( J:62272 )

• reduced network of embryonic capillary blood vessels at E11.5

myocardium hypoplasia ( J:74328 )

• at E11.5, homozygotes display a hypoplastic myocardium relative to wild-type embryos

myocardial trabeculae hypoplasia ( J:74328 )

• at E11.5, homozygous embryos display trabecular hypoplasia

trabecula carnea hypoplasia ( J:74328 )

• at E11.5, homozygotes fail to compact the ventricular myocardium into the multilayer structure that is required to sustain cardiac function

thin myocardium ( J:62272 )

• at E10.5 and E11.5, homozygotes display reduced thickness of the myocardium

abnormal cardiovascular development ( J:74328 )

increased angiogenesis ( J:74328 )

• at E11.5, homozygotes show an significant increase in vascularization along the paraspinal region, within the developing brain and the retina; as a result, all mutant embryos appear grossly hyperemic

abnormal vascular endothelial cell development ( J:74328 )

• at E11.5, the endothelial cells of the mutant endocardium fail to make direct contact with the underlying myocardial cells which appear pyknotic rather than stratified

ventricular hypoplasia ( J:74328 )

• at E11.5, mutant hearts display contact gaps at the endocardial-myocardial junction possibly accounting for the loss of myocytes that result in ventricular hypoplasia

thin ventricular wall ( J:74328 )

• at E11.5, myocardial cells fail to stratify normally resulting in a thin ventriular wall

pericardial effusion ( J:74328 )

• at E11.5, homozygotes display significant pericardial effusion associated with an enlarged, blood-filled ventricle

abnormal cardiovascular system physiology ( J:62272 , J:74328 )

• embryonic lethality at E11.5 is attributed to severe cardiac failure resulting from abnormal cardiovascular development (J:74328)

increased vascular permeability ( J:74328 )

• in some cases, vascular permeability is impaired with extravazation of erythrocytes into adjacent tissue

embryonic growth retardation ( J:62272 )

• at E11.5, viable homozygous embryos exhibit an overall growth retardation relative to wild-type or heterozygous embryos

decreased embryo size ( J:62272 )

• at E11.5, viable homozygous embryos are smaller than wild-type embryos

abnormal extraembryonic tissue morphology ( J:62272 )

abnormal placenta vasculature ( J:62272 , J:74328 )

• at E11.5, homozygotes display significant differences in fetal and maternal vascular channels; vascular channels are scant and contain few erythrocytes (J:62272)

• at E11.5, mutant placentas fail to develop a complex capillary network; however, reduced placental angiogenesis is in marked contrast with the excessive systemic vascularization observed in hyperemic mutant embryos (J:74328)

abnormal placental labyrinth vasculature morphology ( J:62272 )

• reduced network of embryonic capillary blood vessels at E11.5

abnormal trophoblast giant cell morphology ( J:62272 )

• at E11.5, mutant placentas lack the distinct separation between fetal and maternal sinuses due to the presence of densely packed trophoblast cells

• placental trophoblast cells display erythrophagocytic activity indicative of vascular defects

abnormal spongiotrophoblast layer morphology ( J:62272 )

• at E11.5, mutant placentas exhibit less vascularized spongiotrophoblast layers

abnormal placenta labyrinth morphology ( J:62272 )

• at E11.5, the labyrinth zone is poorly developed

abnormal definitive hematopoiesis ( J:74328 )

• at E11.5, homozygotes display failure of megakaryocyte and erythroid differentiation

• at E11.5, mutant livers contain excessive nucleated erythrocytes in dilated sinusoids

absent megakaryocytes ( J:74328 )

• at E11.5, mutant livers lack mature megakaryocytes; a significant number of cells display fragmented nuclei suggestive of apoptosis

abnormal retina pigmentation ( J:74328 )

• at E11.5, mutant eyes are difficult to visualize due to a paucity of retinal pigmention

abnormal lens development ( J:74328 )

• at E11.5, mutant eyes exhibit defective lens formation

abnormal lens epithelium morphology ( J:74328 )

• at E11.5, mutant lenses fail to form a lining epithelium

• mutant rudimentary lenses are surrounded by excessively abundant small vessels relative to wild-type lenses