behavior/neurological
• mutants can be unquestionably distinguished from normal siblings at 12 days of age
(J:11963)
• when the mouse is lifted the hind limbs flex to the trunk rather than extend as they would for a normal mouse; occasionally the fore limbs will also flex
(J:11963)
• during forward motion hind limbs show stiffness on forward motion and move in a wider arc than do hind limbs of normal mice
(J:11963)
• hind limbs displace in a rapid vertical direction during locomotion
(J:13469)
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• during locomotion
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• hind limbs are splayed out when mouse is at rest
• by 6 days of age impaired hind limb coordination is obvious
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growth/size/body
• for several weeks growth rate is reduced compared to that of normal siblings
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reproductive system
• likely due to inability to mate
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