Phenotypes associated with this allele

• Allele Symbol: Sig
• Allele Name: sightless
• Allele ID: MGI:1861182
• Summary: 3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Sig/Sig	involves: 101/H * C3H/HeH * T Stock	MGI:3795432
hm2	Sig/Sig	involves: 101/H * C3H/HeH	MGI:3797486
ht3	Sig/Sig^+	involves: 101/H * C3H/HeH * T Stock	MGI:3795431

Genotype
MGI:3795432

hm1

• Allelic Composition: Sig/Sig
• Genetic Background: involves: 101/H * C3H/HeH * T Stock

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

perinatal lethality, complete penetrance ( J:13435 )

• all homozygotes die sometime around birth

limbs/digits/tail

abnormal autopod morphology ( J:13435 )

• some have hindfoot anomalies, notably syndactyly

syndactyly ( J:13435 )

nervous system

hydrocephaly ( J:13435 )

• in all homozygotes, more pronounced in the homozygote than the heterozygote

Genotype
MGI:3797486

hm2

• Allelic Composition: Sig/Sig
• Genetic Background: involves: 101/H * C3H/HeH

hearing/vestibular/ear

abnormal ear morphology ( J:136112 )

abnormal cochlea morphology ( J:136112 )

abnormal crista ampullaris morphology ( J:136112 )

abnormal membranous labyrinth morphology ( J:136112 )

• only one anomalous semi-circular duct is present

abnormal utricle morphology ( J:136112 )

abnormal utricular macula morphology ( J:136112 )

• macula is missing

abnormal vestibular saccule morphology ( J:136112 )

abnormal cochlear labyrinth morphology ( J:136112 )

• poorly coiled

absent endolymphatic duct ( J:136112 )

absent endolymphatic sac ( J:136112 )

Genotype
MGI:3795431

ht3

• Allelic Composition: Sig/Sig⁺
• Genetic Background: involves: 101/H * C3H/HeH * T Stock

vision/eye

eyelids open at birth ( J:5021 , J:13435 )

• both eyes are open at birth, leading to blindness (J:5021)

• fully penetrant dominant mutation (J:13435)

binocular blindness ( J:13435 )

nervous system

hydrocephaly ( J:13435 )

• slight in the heterozygote