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Allele Symbol Allele Name Allele ID |
Cdh11tm1Mta targeted mutation 1, Masatoshi Takeichi MGI:1861184 |
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| Summary |
3 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
| N |
• at E9.0, homozygous mutant embryos display normal epitheial somite patterning relative to wild-type embryos
• moreover, homozygous mutant mice survive to adulthood
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• at E9.0, double mutant embryos display a more severe disorganization and fragmentation of the epithelial somites than single Cdh2tm1Hyn embryos
• each epithelial somite is cleaved into rostral and caudal halves just after somite formation, as in single Cdh2tm1Hyn embryos; however, in double mutant embryos, each half is further fragmented into smaller clusters, and the caudal and rostral compartments tend to separate from each other
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• at 13 weeks, delayed compared to in Bhlhe22tm1Meg homozygotes
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• mice exhibit a reduction of the corticospinal tract compared with wild-type mice although not as severe as in Bhlhe22tm1Meg homozygotes
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 06/12/2024 MGI 6.13 |
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