Phenotypes associated with this allele

• Allele Symbol: Li
• Allele Name: lined
• Allele ID: MGI:1861199
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
ht1	Li/Li^+	Not Specified	MGI:4450979
ot2	Li/Y	Not Specified	MGI:4450980

Genotype
MGI:4450979

ht1

• Allelic Composition: Li/Li⁺
• Genetic Background: Not Specified

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

prenatal lethality, incomplete penetrance ( J:13961 , J:46359 )

♀ • slightly less than the expected number of heterozygous mutant females are detected at weaning, suggesting possible prenatal loss (J:13961)

♀ • 23% of heterozygous mutant females die in utero (J:46359)

growth/size/body

decreased birth weight ( J:46359 )

♀ • at birth, heterozygous mutant females weigh 91.7 +/- 2.8% of wild-type controls

decreased body weight ( J:46359 )

♀ • at weaning, heterozygous mutant females weigh 95.4 +/- 2.4% of wild-type controls

integument

striated fur ( J:13961 , J:46359 )

♀ • heterozygous mutant females exhibit a very fine striping, that is often seen only on the dorsal body area and can be difficult to detect (J:13961)

♀ • heterozygous mutant females are first recognized at 8-10 days postnatally by the presence of dark fine stripes on the coat (J:46359)

♀ • however, no gross abnormalities are observed in dorsal skin or hair of whole body sections and other tissues appear histologicallly normal (J:46359)

Genotype
MGI:4450980

ot2

• Allelic Composition: Li/Y
• Genetic Background: Not Specified

mortality/aging

prenatal lethality, complete penetrance ( J:13961 )

♂ • hemizygous mutant males die prior to birth

embryonic lethality during organogenesis, complete penetrance ( J:46359 )

♂ • hemizygous mutant males die at approximately E10.5-E11.5

embryo

decreased embryo size ( J:46359 )

♂ • by E10.5, all hemizygous mutant embryos are significantly smaller than wild-type embryos

♂ • however, no significant differences are noted at E9.5

growth/size/body

decreased embryo size ( J:46359 )

♂ • by E10.5, all hemizygous mutant embryos are significantly smaller than wild-type embryos

♂ • however, no significant differences are noted at E9.5