Phenotypes associated with this allele

• Allele Symbol: Far
• Allele Name: first arch
• Allele ID: MGI:1861221
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Far/Far	BALB/cGaBc-Far	MGI:4418705
ot2	Far/?	involves: ICR	MGI:4356188

Genotype
MGI:4418705

hm1

• Allelic Composition: Far/Far
• Genetic Background: BALB/cGaBc-Far

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

neonatal lethality, incomplete penetrance ( J:6434 )

• most affected animals do not survive the first postnatal day

craniofacial

abnormal maxillary-premaxillary suture morphology ( J:6434 )

• premaxilla has an indistinct suture with the maxilla

abnormal basisphenoid bone morphology ( J:6434 )

• the basisphenoid bone is misshaped and asymmetric

abnormal alisphenoid bone morphology ( J:6434 )

• alisphenoid bone is misshaped, small and sometimes fragmented

abnormal pterygoid process morphology ( J:6434 )

• pterygoid processes are small and misshapen

absent temporal bone squamous part ( J:6434 )

• almost entirely absent, including the body and most or all of the zygomatic processes

thick zygomatic arch ( J:6434 )

• the entire zygomatic arch, including the zygomatic bone, is a jagged mass and is five times the normal thickness

long incisors ( J:6434 )

• extreme overgrowth of the incisors

malocclusion ( J:6434 )

absent mandibular coronoid process ( J:6434 )

• lacks most of the coronoid process but the mandible is otherwise normal

abnormal maxilla morphology ( J:6434 )

• lacks normal connection to the frontal bone

abnormal premaxilla morphology ( J:6434 )

• misshapen, thickened and has an indistinct suture with the maxilla

abnormal palatine bone horizontal plate morphology ( J:6434 )

• palatine processes are displaced laterally

abnormal zygomatic bone morphology ( J:6434 )

• an abnormal condrification center at its squamosal end

absent malleus manubrium ( J:6434 )

• the handle is missing in newborns

abnormal palatal shelf morphology ( J:7301 )

• deficient and irregular palatal shelves and orbital ridges

cleft secondary palate ( J:6434 )

• primary palate and lip are intact

pointed snout ( J:6434 )

digestive/alimentary system

abnormal palatine bone horizontal plate morphology ( J:6434 )

• palatine processes are displaced laterally

abnormal palatal shelf morphology ( J:7301 )

• deficient and irregular palatal shelves and orbital ridges

cleft secondary palate ( J:6434 )

• primary palate and lip are intact

skeleton

abnormal maxillary-premaxillary suture morphology ( J:6434 )

• premaxilla has an indistinct suture with the maxilla

abnormal basisphenoid bone morphology ( J:6434 )

• the basisphenoid bone is misshaped and asymmetric

abnormal alisphenoid bone morphology ( J:6434 )

• alisphenoid bone is misshaped, small and sometimes fragmented

abnormal pterygoid process morphology ( J:6434 )

• pterygoid processes are small and misshapen

absent temporal bone squamous part ( J:6434 )

• almost entirely absent, including the body and most or all of the zygomatic processes

thick zygomatic arch ( J:6434 )

• the entire zygomatic arch, including the zygomatic bone, is a jagged mass and is five times the normal thickness

long incisors ( J:6434 )

• extreme overgrowth of the incisors

malocclusion ( J:6434 )

absent mandibular coronoid process ( J:6434 )

• lacks most of the coronoid process but the mandible is otherwise normal

abnormal maxilla morphology ( J:6434 )

• lacks normal connection to the frontal bone

abnormal premaxilla morphology ( J:6434 )

• misshapen, thickened and has an indistinct suture with the maxilla

abnormal palatine bone horizontal plate morphology ( J:6434 )

• palatine processes are displaced laterally

abnormal zygomatic bone morphology ( J:6434 )

• an abnormal condrification center at its squamosal end

absent malleus manubrium ( J:6434 )

• the handle is missing in newborns

abnormal cartilage morphology ( J:6434 )

• the stylohyal cartilage lacks normal connection with the styloid process of the temporal bone but is connected normally to the stapes

hearing/vestibular/ear

absent malleus manubrium ( J:6434 )

• the handle is missing in newborns

vision/eye

eyelids open at birth ( J:6434 )

• open eye at birth in 68 percent of animals with cleft palate

nervous system

abnormal maxillary nerve morphology ( J:7301 )

• abnormal maxillary branch of the trigeminal nerve associated with an abnormal pattern of mesenchymal cells between the vibrissae and palate

integument

abnormal vibrissa morphology ( J:7301 )

• deficiency and disorganized pattern of maxillary vibrissae

• absence of infraorbital vibrissae in 76% of homozygotes

growth/size/body

long incisors ( J:6434 )

• extreme overgrowth of the incisors

malocclusion ( J:6434 )

abnormal palatine bone horizontal plate morphology ( J:6434 )

• palatine processes are displaced laterally

abnormal palatal shelf morphology ( J:7301 )

• deficient and irregular palatal shelves and orbital ridges

cleft secondary palate ( J:6434 )

• primary palate and lip are intact

pointed snout ( J:6434 )

Genotype
MGI:4356188

ot2

• Allelic Composition: Far/?
• Genetic Background: involves: ICR

nervous system

nervous system phenotype ( J:2823 )

N • rhombomeres are normal

abnormal trigeminal nerve morphology ( J:2823 )

• at embryonic day 12, 32 of 48 embryos from heterozygous intercrosses have a bifurcated maxillary nerve with a large, clear nerve-free area between the two main trunks, and retinoic acid treatment does not prevent or alter this phenotype

craniofacial

abnormal palate development ( J:2823 )

• a rod of ectopic cartilage lateral to the posterior palate, immediately dorsolateral to the lateral end of the palatine bone, is found by embryonic day 15

digestive/alimentary system

abnormal palate development ( J:2823 )

• a rod of ectopic cartilage lateral to the posterior palate, immediately dorsolateral to the lateral end of the palatine bone, is found by embryonic day 15

growth/size/body

abnormal palate development ( J:2823 )

• a rod of ectopic cartilage lateral to the posterior palate, immediately dorsolateral to the lateral end of the palatine bone, is found by embryonic day 15