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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Xpl
X-linked polydactyly
MGI:1861233
Summary 5 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Xpl/Xpl involves: C3HeB/FeJ * C57BL/6J * English fancy stock MGI:3810964
ht2
 		Xpl/Xpl+ involves: C3HeB/FeJ * C57BL/6J * English fancy stock MGI:3810955
ht3
 		Xpl/Xpl+ involves: C57BL/6J * MSM MGI:3811009
ot4
 		Xpl/Y involves: C3HeB/FeJ * C57BL/6J * English fancy stock MGI:3810954
ot5
 		Xpl/Y involves: C57BL/6J * MSM MGI:3811008


Genotype
MGI:3810964
hm1
Allelic
Composition		 Xpl/Xpl
Genetic
Background		 involves: C3HeB/FeJ * C57BL/6J * English fancy stock
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Xpl mutation (2 available); any Xpl mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
limbs/digits/tail
polydactyly ( J:6343 )
• homozygotes, like heterozygotes, display preaxial polydactyly of the hind feet with hyperphalangy of the first digit and tibial hemimelia




Genotype
MGI:3810955
ht2
Allelic
Composition		 Xpl/Xpl+
Genetic
Background		 involves: C3HeB/FeJ * C57BL/6J * English fancy stock
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Xpl mutation (2 available); any Xpl mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
limbs/digits/tail
polydactyly ( J:6343 , J:24756 )
• the expression of polydactyly varies from a barely discernible thickened hallux or elongated first toe on one feet to multiple extra toes on both hind feet (J:6343)
• Background Sensitivity: penetrance is 80 to 90% on this background (J:6343)
• preaxial polydactyly of the hind feet (J:24756)
hemimelia ( J:6343 , J:24756 )
• one or both hind legs may be twisted resulting in abnormal positioning of the feet (J:6343)
• 42% of hemizygous males and 12% of heterozygous females display hemimelia (J:6343)
• tibial hemimelia of one or both hind legs (J:24756)




Genotype
MGI:3811009
ht3
Allelic
Composition		 Xpl/Xpl+
Genetic
Background		 involves: C57BL/6J * MSM
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Xpl mutation (2 available); any Xpl mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
limbs/digits/tail
abnormal zone of polarizing activity morphology ( J:38196 )
• a duplicated zone of polarizing activity forms at the anterior margin of the limb buds and this is not suppressed by the presence of the MSM-derived modifier that suppresses this overgrowth in other preaxial polydactylous mutants

embryo
abnormal zone of polarizing activity morphology ( J:38196 )
• a duplicated zone of polarizing activity forms at the anterior margin of the limb buds and this is not suppressed by the presence of the MSM-derived modifier that suppresses this overgrowth in other preaxial polydactylous mutants




Genotype
MGI:3810954
ot4
Allelic
Composition		 Xpl/Y
Genetic
Background		 involves: C3HeB/FeJ * C57BL/6J * English fancy stock
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Xpl mutation (2 available); any Xpl mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
limbs/digits/tail
polydactyly ( J:6343 , J:24756 )
• the expression of polydactyly varies from a barely discernible thickened hallux or elongated first toe on one feet to multiple extra toes on both hind feet (J:6343)
• Background Sensitivity: penetrance is 90-95% on this background (J:6343)
• preaxial polydactyly of the hind feet (J:24756)
hemimelia ( J:6343 , J:24756 )
• one or both hind legs may be twisted resulting in abnormal positioning of the feet (J:6343)
• 42% of hemizygous males and 12% of heterozygous females display hemimelia (J:6343)
• tibial hemimelia of one or both hind legs (J:24756)

endocrine/exocrine glands
cryptorchism ( J:6343 )
• in all males, causing infertility

renal/urinary system
kidney cyst ( J:6343 )
• observed in some males
hydronephrosis ( J:6343 )
• observed in some males
absent kidney ( J:6343 )
• observed in some males
hydroureter ( J:6343 )
• observed in some males

reproductive system
cryptorchism ( J:6343 )
• in all males, causing infertility

growth/size/body
kidney cyst ( J:6343 )
• observed in some males




Genotype
MGI:3811008
ot5
Allelic
Composition		 Xpl/Y
Genetic
Background		 involves: C57BL/6J * MSM
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Xpl mutation (2 available); any Xpl mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
limbs/digits/tail
abnormal zone of polarizing activity morphology ( J:38196 )
• a duplicated zone of polarizing activity forms at the anterior margin of the limb buds and this is not suppressed by the presence of the MSM-derived modifier that suppresses this overgrowth in other preaxial polydactylous mutants

embryo
abnormal zone of polarizing activity morphology ( J:38196 )
• a duplicated zone of polarizing activity forms at the anterior margin of the limb buds and this is not suppressed by the presence of the MSM-derived modifier that suppresses this overgrowth in other preaxial polydactylous mutants




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Send questions and comments to User Support. 		last database update
10/29/2024
MGI 6.24 		The Jackson Laboratory