All Phenotypes Ds MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Ds
disorganization
MGI:1861455

Summary

3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Ds/Ds	involves: 129T1/Sv * C3H/HeJ * DA/Hu * DBA/1J	MGI:3841151
hm2	Ds/Ds	involves: 129T1/Sv * DA/Hu * DBA/1J	MGI:3840853
ht3	Ds/Ds⁺	involves: 129T1/Sv * DA/Hu * DBA/1J	MGI:3840817

Allelic Composition	Ds/Ds
Genetic Background	involves: 129T1/Sv * C3H/HeJ * DA/Hu * DBA/1J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ds mutation (1 available); any Ds mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

embryonic lethality, incomplete penetrance ( J:13012 )

• 21% of implanted embryos from heterozygous matings are dead by E12

• in utero examination shows dead embryos in well-established fetal membranes and more implantation sites compared to the number of term fetuses suggesting lethal effects occur after implantation

Allelic Composition	Ds/Ds
Genetic Background	involves: 129T1/Sv * DA/Hu * DBA/1J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ds mutation (1 available); any Ds mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

decreased survivor rate ( J:15079 )

• some may be normal and viable

prenatal lethality, complete penetrance ( J:13012 )

• death can occur at any point between post-implantation and before term

embryo

abnormal embryo development ( J:13012 )

Allelic Composition	Ds/Ds⁺
Genetic Background	involves: 129T1/Sv * DA/Hu * DBA/1J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ds mutation (1 available); any Ds mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

decreased survivor rate ( J:13012 )

perinatal lethality, incomplete penetrance ( J:13012 )

• the most severe abnormalities are lethal

embryo

abnormal embryo development ( J:13012 )

mirror image duplication ( J:13012 )

• duplicated limbs are common

abnormal embryonic tissue morphology ( J:13012 )

• a mix of abnormalities is seen that varies in number and type from mouse to mouse

neoplasm

increased skin hamartoma incidence ( J:13012 )

craniofacial

cranioschisis ( J:13012 )

skeleton

cranioschisis ( J:13012 )

scoliosis ( J:13012 )

• in sacral and caudal locations

limbs/digits/tail

polydactyly ( J:13012 )

integument

increased skin hamartoma incidence ( J:13012 )

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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