Phenotypes associated with this allele

• Allele Symbol: Om
• Allele Name: ovum mutant
• Allele ID: MGI:1861473
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
ht1	Om/Om^+	either: (DDK x C57BL/6J)F1 or (DDK x KK)F1 or (DDK x NC)F1	MGI:4421789

Genotype
MGI:4421789

ht1

• Allelic Composition: Om/Om⁺
• Genetic Background: either: (DDK x C57BL/6J)F1 or (DDK x KK)F1 or (DDK x NC)F1

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality before implantation, incomplete penetrance ( J:5498 , J:24716 )

• embryonic survival is halved (J:5498)

• death occurs at the morula-blastocyst and pre-egg cylinder stages (J:5498)

• embryonic death also occurs when the source of eggs is a transplanted ovary, implicating an abnormal egg and sperm interaction as the cause of lethality (J:24716)

embryo

abnormal embryo development ( J:5498 )

abnormal trophoblast layer morphology ( J:5498 )

reproductive system

abnormal female meiosis ( J:98846 )

♀ • meiotic drive occurs at MII but preferential death of one subsequent genotypic class of embryo does not play a large role in transmission ratio distortion

transmission ratio distortion ( J:98846 )

• there is maternal transmission ratio distortion in favor of DDK alleles

• due to nonrandom segregation of chromatids at the second meiotic division

reduced female fertility ( J:5498 )

♀

cellular

abnormal female meiosis ( J:98846 )

♀ • meiotic drive occurs at MII but preferential death of one subsequent genotypic class of embryo does not play a large role in transmission ratio distortion

maternal effect ( J:5498 )