All Phenotypes Clock<m1Jt> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Clock^m1Jt
Clock
MGI:1861634

Summary

19 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Clock^m1Jt/Clock^m1Jt	C57BL/6-Clock^m1Jt	MGI:2663351
hm2	Clock^m1Jt/Clock^m1Jt	C57BL/6J-Clock^m1Jt/J	MGI:4366738
hm3	Clock^m1Jt/Clock^m1Jt	involves: BALB/c * C57BL/6 * C57BL/6J * Jcl:ICR	MGI:4366723
hm4	Clock^m1Jt/Clock^m1Jt	involves: BALB/cJ * C57BL/6	MGI:4358256
hm5	Clock^m1Jt/Clock^m1Jt	involves: BALB/cJ * C57BL/6 * C57BL/6J	MGI:4867520
hm6	Clock^m1Jt/Clock^m1Jt	involves: C57BL/6	MGI:3840514
hm7	Clock^m1Jt/Clock^m1Jt	involves: C57BL/6 * C57BL/6J	MGI:4366726
hm8	Clock^m1Jt/Clock^m1Jt	involves: C57BL/6 * C57BL/6J * Jcl:ICR	MGI:4366720
hm9	Clock^m1Jt/Clock^m1Jt	involves: C57BL/6J	MGI:5576784
hm10	Clock^m1Jt/Clock^m1Jt	involves: C57BL/6 * Jcl:ICR	MGI:4366555
ht11	Clock^m1Jt/Clock⁺	B6(C)-Clock^m1Jt	MGI:5515434
ht12	Clock^m1Jt/Clock⁺	C57BL/6-Clock^m1Jt	MGI:2663350
ht13	Clock^m1Jt/Clock⁺	involves: C57BL/6	MGI:4822130
cn14	Clock^m1Jt/Clock^m1Jt Tg(BAC54)36Jt/0	involves: BALB/cJ * C57BL/6 * C57BL/6J * CD-1	MGI:3840515
cx15	Clock^m1Jt/Clock⁺ Usf1^soc/Usf1⁺	(BALB/cJ x C57BL/6J)F1	MGI:5515432
cx16	Clock^m1Jt/Clock⁺ Usf1^soc/Usf1^soc	C.B6-Clock^m1Jt	MGI:5515721
cx17	Clock^m1Jt/Clock⁺ Per2^tm1Jt/Per2⁺ Usf1^soc/?	involves: 129S6/SvEvTac * BALB/cJ * C57BL/6J	MGI:5515433
cx18	Clock^m1Jt/Clock^m1Jt Lep^ob/Lep^ob	involves: BALB/c * C57BL/6 * C57BL/6J * Jcl:ICR	MGI:4366719
cx19	Clock^m1Jt/Clock⁺ Tg(CMV-Usf1)1Jt/0	involves: C57BL/6J	MGI:5515431

Allelic Composition	Clock^m1Jt/Clock^m1Jt
Genetic Background	C57BL/6-Clock^m1Jt

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Clock^m1Jt mutation (3 available); any Clock mutation (104 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

abnormal behavior ( J:101849 )

• in a forced-swim test, female mice exhibit less immobility compared with wild-type mice

• in constant darkness, female mice exhibit reduced immobility in a forced-swim test compared with similarly treated wild-type mice

• however, anxiety and depressive-like behavior are not increased

increased exploration in new environment ( J:101849 )

• during constant darkness in an open field, mice spend more time exploring the center than wild-type mice

• in an elevated plus maze, female mice exhibit increased number of arm entries compared with wild-type mice

abnormal eating behavior ( J:98343 )

• when fed a high fat diet during the light and dark phase

abnormal food intake ( J:98343 )

• food intake is increased during the light period and decreased during the dark phase compared with wild-type mice

hyperactivity ( J:98343 , J:101849 )

	• during the light phase (J:98343)
	• in female mice (J:101849)

increased vertical activity ( J:101849 )

• in female mice in an open field test

abnormal circadian behavior ( J:65198 )

• under dark dark conditions, mice spend more time awake than similarly treated wild-type mice

• delta energy accumulates over 28 hours unlike 24 in wild-type mice

abnormal locomotor circadian rhythm ( J:98343 )

• activity levels are increased during the light period and decreased during the dark phase compared with wild-type mice

prolonged circadian behavior period ( J:18005 )

• mutants exhibit extremely long circadian periods of 26 to 29 hours on initial transfer to constant darkness

abnormal circadian behavior persistence ( J:18005 )

• the long circadian period is followed by a complete loss of circadian rhythmicity after about 2 weeks in constant darkness, although a residual ultradian periodicity of 6-9 hours remains

abnormal circadian behavior phase ( J:98343 )

• in constant darkness, mice exhibit a 3 to 4 hour increase in free-running rhythm of locomotor activity compared with wild-type mice

• after a few weeks in constant darkness, mice exhibit a break-down in circadian rhymicity unlike similarly treated wild-type mice

• mice exhibit a change in the temporal pattern of total activity during the dark phase with attenuation of the two peaks of activity normally observed in wild-type mice

• as early as 3 weeks of age, diurnal rhythm of food intake is severely altered with only a 53% increase in food intake during the dark phase compared with 75% in wild-type mice

abnormal sleep duration ( J:65198 )

• mice spend 18% less time asleep during the entire 24 hour light dark cycle compared with wild-type mice

• during the 12 hour light phase, sleep episodes are shorter than in wild-type mice

• under dark dark conditions, mice spend more time awake and less time in NREM sleep than wild-type mice

abnormal sleep pattern ( J:65198 )

• during the 12 hour light and 12 hour dark phases, mice spend less time in non-REM sleep than wild-type mice

• during the 12 hour dark phase, REM sleep is longer than in wild-type mice

• whether sleep deprived or not, total NREM delta energy is decreased compared to in wild-type mice

• delta energy accumulates over 28 hours unlike 24 in wild-type mice

• following sleep deprivation, mice exhibit less sleep and spend less time in REM sleep during the 12 hour dark phase compared with similarly treated wild-type mice

abnormal circadian sleep/wake cycle ( J:65198 )

• delta energy accumulates over 28 hours unlike 24 in wild-type mice

homeostasis/metabolism

increased circulating glucose level ( J:98343 )

• at 6 to 7 months when fed a regular diet

decreased circulating corticosterone level ( J:98343 )

increased circulating leptin level ( J:98343 )

• during the light phase when fed a regular and during the light and dark phase when fed a high fat diet

increased circulating cholesterol level ( J:98343 )

• at 6 to 7 months when fed a regular diet

increased circulating triglyceride level ( J:98343 )

• at 6 to 7 months when fed a regular diet

decreased energy expenditure ( J:98343 )

• 10% overall

increased susceptibility to diet-induced obesity ( J:98343 )

• when fed a high fat diet, mice exhibit increased obesity with decreased gains in lean mass and increased gains in fat mass compared with similarly treated wild-type mice

• by 6 weeks, mice fed a high fat diet is increased compared to in similarly treated wild-type mice

abnormal basal metabolism ( J:98343 )

• metabolic rate is increased during the light period and decreased during the dark phase compared with wild-type mice

cardiovascular system

abnormal circadian regulation of systemic arterial blood pressure ( J:125921 )

• diurnal variation in mean arterial pressure is disrupted during the light phase

abnormal circadian regulation of heart rate ( J:125921 )

• diurnal variation in heart rate is disrupted during the dark phase

decreased heart rate ( J:125921 )

• only during the active phase

adipose tissue

increased fat cell size ( J:98343 )

• when fed a high fat diet

increased percent body fat/body weight ( J:98343 )

• when fed a high fat diet, mice exhibit a 75% increase in fat mass compared with 25% in similarly treated wild-type mice

growth/size/body

increased body weight ( J:98343 )

• when fed a regular or high fat diet

increased susceptibility to diet-induced obesity ( J:98343 )

• when fed a high fat diet, mice exhibit increased obesity with decreased gains in lean mass and increased gains in fat mass compared with similarly treated wild-type mice

• by 6 weeks, mice fed a high fat diet is increased compared to in similarly treated wild-type mice

liver/biliary system

hepatic steatosis ( J:98343 )

• when fed a high fat diet

abnormal hepatocyte physiology ( J:98343 )

• when mice are fed a high fat diet, hepatocytes exhibit lipid engorgement and glycogen accumulation compared with similarly treated wild-type mice

Allelic Composition	Clock^m1Jt/Clock^m1Jt
Genetic Background	C57BL/6J-Clock^m1Jt/J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Clock^m1Jt mutation (3 available); any Clock mutation (104 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

digestive/alimentary system

abnormal intestinal absorption ( J:153782 )

• peptide absorption is lower than in wild-type mice while absorption of glucose and lipid is higher

increased intestinal glucose absorption ( J:153782 )

• glucose absorption is higher than in wild-type mice

abnormal intestinal lipid absorption ( J:153782 )

• lipid absorption by enterocytes is increased compared to in wild-type mice

abnormal enterocyte physiology ( J:153782 )

• lipid absorption and secretion by enterocytes is greater than in wild-type cells

homeostasis/metabolism

abnormal intestinal lipid absorption ( J:153782 )

• lipid absorption by enterocytes is increased compared to in wild-type mice

Allelic Composition	Clock^m1Jt/Clock^m1Jt
Genetic Background	involves: BALB/c * C57BL/6 * C57BL/6J * Jcl:ICR

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Clock^m1Jt mutation (3 available); any Clock mutation (104 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

homeostasis/metabolism

decreased physiological sensitivity to xenobiotic ( J:128504 )

• kaolin-induced writhing day-night fluctuations are abolished and writhing is decreased during the inactive phase compared to in similarly treated wild-type mice

• however, kaolin-induced bradykinin production and blood pressure suppression are normal

Allelic Composition	Clock^m1Jt/Clock^m1Jt
Genetic Background	involves: BALB/cJ * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Clock^m1Jt mutation (3 available); any Clock mutation (104 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

prolonged circadian behavior period ( J:18005 )

• mutants exhibit extremely long circadian periods of 26 to 29 hours on initial transfer to constant darkness

arrhythmic circadian behavior persistence ( J:18005 )

• the long circadian period is followed by a complete loss of circadian rhythmicity after about 2 weeks in constant darkness, although a residual ultradian periodicity of 6-9 hours remains

• however, a single 6 hour light pulse, given after the loss of rhythmicity in constant darkness, can restore the long periodicity temporarily

nervous system

nervous system phenotype ( J:18005 )

N	• mutants do not exhibit any gross developmental or anatomical defects in the suprachiasmatic nucleus

Allelic Composition	Clock^m1Jt/Clock^m1Jt
Genetic Background	involves: BALB/cJ * C57BL/6 * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Clock^m1Jt mutation (3 available); any Clock mutation (104 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

abnormal medium spiny neuron morphology ( J:166742 )

• nucleus accumbens medium spiny neurons have longer and more complex dendrites and exhibit reduced GluR1 expression than those of wild-type mice

• lithium treatment reverses the changes in dendritic morphology

abnormal nucleus accumbens morphology ( J:166742 )

• nucleus accumbens medium spiny neurons have longer and more complex dendrites and exhibit reduced GluR1 expression than those of wild-type mice

abnormal nervous system electrophysiology ( J:166742 )

• phase coupling between nucleus accumbens low-gamma oscillatory activity and delta activity is disrupted and prelimbic cortex low-gamma cross-frequency phase coupling tends to be decreased

• mutant mice fail to display the nucleus accumbens low-gamma cross-frequency phase coupling observed in wild-type mice during behaviorally immobile periods

• mutants exhibit neuronal entrainment deficits in nucleus accumbens

• lithium treatment ameliorates the nucleus accumbens phase-signaling dysfunction

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
bipolar disorder		DOID:3312		J:166742

Allelic Composition	Clock^m1Jt/Clock^m1Jt
Genetic Background	involves: C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Clock^m1Jt mutation (3 available); any Clock mutation (104 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

homeostasis/metabolism

decreased circulating estradiol level ( J:92343 )

• during diestrus and post-coitus days 11 and 17

increased circulating estradiol level ( J:92343 )

• during proestrus

decreased circulating progesterone level ( J:92343 )

• during proestrus

increased circulating progesterone level ( J:92343 )

• during proestrus

abnormal glucose homeostasis ( J:131694 )

• diurnal variation in glucose levels is disrupted

• fail to display a significant time dependent variation in their response to glucose or insulin

• do not develop frank diabetes when fed a high fat diet

impaired gluconeogenesis ( J:131694 )

increased insulin sensitivity ( J:131694 )

• profound hypoglycemic response regardless of the time of day

abnormal luteinizing hormone level ( J:92343 )

• mice fail to exhibit an increase in luteinizing hormone level on the day of proestrus unlike wild-type mice

• estradiol benzoate-injected mice fail to exhibit a surge in luteinizing hormone unlike similarly treated wild-type mice

• however, elevation of luteinizing hormone in response to gonadotropin-releasing hormone treatment is normal

decreased circulating luteinizing hormone level ( J:92343 )

• estradiol benzoate-injected mice fail to exhibit a surge in luteinizing hormone unlike similarly treated wild-type mice

• however, elevation of luteinizing hormone in response to gonadotropin-releasing hormone treatment is normal

abnormal lipid homeostasis ( J:131694 )

• diurnal variation in triglyceride levels is disrupted

decreased physiological sensitivity to xenobiotic ( J:92343 )

• estradiol benzoate-injected mice fail to exhibit a surge in luteinizing hormone unlike similarly treated wild-type mice

• however, elevation of luteinizing hormone in response to gonadotropin-releasing hormone treatment is normal

behavior/neurological

enhanced behavioral response to cocaine ( J:99868 )

• following chronic cocaine treatment, behavioral sensitization is increased compared with similarly treated wild-type mice

• mice exhibit a greater of place conditioning to a lower dose of cocaine compared with similarly treated wild-type mice

abnormal response to new environment ( J:99868 )

• in a novel environment, locomotor activity increased compared to in wild-type mice

hyperactivity ( J:99868 )

• in a novel environment

increased vertical activity ( J:99868 )

• in a novel environment

abnormal circadian behavior ( J:40363 )

• when kept in darkness for intervals of 10 days mice exhibit reduced amplitude compared to similarly treated wild-type mice, especially after the second 10-day interval

prolonged circadian behavior period ( J:40363 )

abnormal circadian behavior phase ( J:99868 )

• mice exhibit more activity throughout the light and dark cycle with more pronounced differences at the beginning of the dark cycle and the beginning of the light cycle compared with wild-type mice

reproductive system

reproductive system phenotype ( J:92343 )

N	• ovarian tissue morphology is normal

prolonged estrus ( J:92343 )

short proestrus ( J:92343 )

prolonged estrous cycle ( J:92343 )

abnormal pregnancy ( J:92343 )

• mid-gestation mice exhibit increased post-coitus day 14 and full-term rate of fetal resorption and pregnancy failure at full-term compared with wild-type mice

• pseudopregnancy is shortened compared to in similarly treated wild-type mice

abnormal parturition ( J:92343 )

• 43% of females exhibit an extended but non-productive labor or fail to enter labor and fully reabsorb full-term fetuses unlike wild-type mice

nervous system

abnormal single cell response ( J:99868 )

• dopamine cell firing and bursting are enhanced compared with wild-type mice

Allelic Composition	Clock^m1Jt/Clock^m1Jt
Genetic Background	involves: C57BL/6 * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Clock^m1Jt mutation (3 available); any Clock mutation (104 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

Altered cell cycle progression in the secondary hair germ of hair follicles of Bmal1^tm1Bra/Bmal1^tm1Bra and Clock^m1Jt/Clock^m1Jt mice

integument

abnormal hair cycle ( J:151782 )

• mice exhibit a delay in the first synchronized anagen that persists through out the hair cycle that is not as severe as in Arntl^tm1Bra homozygotes

abnormal hair cycle anagen phase ( J:151782 )

• the first synchronized anagen is delayed compared to in wild-type mice that is not as severe as in Arntl^tm1Bra homozygotes

Allelic Composition	Clock^m1Jt/Clock^m1Jt
Genetic Background	involves: C57BL/6 * C57BL/6J * Jcl:ICR

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Clock^m1Jt mutation (3 available); any Clock mutation (104 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

abnormal circadian behavior ( J:125037 )

• under light light conditions during lactation, mice exhibit delayed phase angle of locomotor activity onset during early developmental periods compared with similarly treated wild-type mice

• however, treatment with melatonin restores phase angle onset

abnormal circadian behavior phase ( J:125037 )

• under light light conditions during lactation, 2 of 30 mice exhibit arrhythmicity of spontaneous activity unlike similarly treated wild-type mice

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
sleep disorder		DOID:535		J:125037

Allelic Composition	Clock^m1Jt/Clock^m1Jt
Genetic Background	involves: C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Clock^m1Jt mutation (3 available); any Clock mutation (104 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

endocrine/exocrine glands

abnormal pancreatic islet morphology ( J:162641 )

• total islet area is reduced by around 20%

• trend toward decreased total pancreatic insulin content

small pancreatic islets ( J:162641 )

abnormal pancreas physiology ( J:162641 )

• islets lack a circadian rhythm, even after forskolin stimulation

• 23% decrease in proliferation of islets

• decrease in levels of expression and/or phase shifts of RNA oscillation of genes involved in insulin signaling, glucose sensing, and islet growth and development

increased pancreatic islet cell apoptosis ( J:162641 )

• trend toward increased islet apoptosis

decreased insulin secretion ( J:162641 )

• islets from 8 month old mutants show an approximate 50% reduction in glucose-stimulated insulin secretion and fail to respond to KCl, indicating a defect in insulin exocytosis

• islets display diminished insulin secretory responses to the cyclase activators forskolin and exendin 4, and 8-bromo-cAMP

• islets from young mice show impaired glucose-stimulated insulin secretion

homeostasis/metabolism

decreased insulin secretion ( J:162641 )

• islets from 8 month old mutants show an approximate 50% reduction in glucose-stimulated insulin secretion and fail to respond to KCl, indicating a defect in insulin exocytosis

• islets display diminished insulin secretory responses to the cyclase activators forskolin and exendin 4, and 8-bromo-cAMP

• islets from young mice show impaired glucose-stimulated insulin secretion

hyperglycemia ( J:162641 )

• glucose levels are elevated across the entire light/dark cycle in 4 month old mutants without a rise in insulin levels during the beginning of the feeding period as is seen in wild-type mice

• mutants show elevated fasting glucose levels at both Zeitgeber time 2 and Zeitgeber time 14

• however, fasting and fed glucose levels in 3 month old mice are normal

impaired glucose tolerance ( J:162641 )

• glucose tolerance tests show a 50% reduction in insulin release that corresponds with elevated glucose levels, particularly at the beginning of the dark period

• however, mice show normal insulin tolerance

increased insulin sensitivity ( J:162641 )

• 3 month old mice have enhanced insulin sensitivity

insulin resistance ( J:162641 )

• gradual onset of insulin resistance

cellular

increased pancreatic islet cell apoptosis ( J:162641 )

• trend toward increased islet apoptosis

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
diabetes mellitus		DOID:9351		J:162641

Allelic Composition	Clock^m1Jt/Clock^m1Jt
Genetic Background	involves: C57BL/6 * Jcl:ICR

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Clock^m1Jt mutation (3 available); any Clock mutation (104 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

behavior/neurological phenotype ( J:116792 )

N	• mice exhibit normal passive avoidance

abnormal spatial learning ( J:116792 )

• escape latency in Morris water maze is increased compared to in wild-type mice

hyperactivity ( J:116792 )

• in an open field test

increased vertical activity ( J:116792 )

• in an open field test

abnormal circadian behavior ( J:103663 , J:116792 )

• the acrophase of spontaneous activity is delayed by 2 to 3 hours compared with in wild-type mice (J:103663)

• however, entrainment is intact (J:103663)

abnormal sleep duration ( J:103663 )

• mice spend less time in non-REM sleep with an increase in waking compared with wild-type mice

abnormal sleep pattern ( J:103663 )

• the acrophase of REM sleep is delayed 4.4 hours compared to in wild-type mice

• the difference in the acrophase between non-REM and REM sleep is 3.5 hours unlike in wild-type mice

• peak electroencephalogram delta power of non-REM sleep appears at the onset of the light period unlike in wild-type mice

abnormal circadian sleep/wake cycle ( J:103663 , J:116792 )

• the acrophase of wake time is delayed by 2 to 3 hours compared with in wild-type mice (J:103663)

• the acrophase of REM sleep is delayed 4.4 hours compared to in wild-type mice (J:103663)

• the difference in the acrophase between non-REM and REM sleep is 3.5 hours unlike in wild-type mice (J:103663)

• peak electroencephalogram delta power of non-REM sleep appears at the onset of the light period unlike in wild-type mice (J:103663)

homeostasis/metabolism

abnormal circadian temperature homeostasis ( J:103663 , J:116792 )

• during the first half of the dark period and at the end of the light period (J:103663)

• the acrophase of body temperature is delayed by 2 to 3 hours compared with in wild-type mice (J:103663)

Allelic Composition	Clock^m1Jt/Clock⁺
Genetic Background	B6(C)-Clock^m1Jt

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Clock^m1Jt mutation (3 available); any Clock mutation (104 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

prolonged circadian behavior period ( J:198519 )

• Background Sensitivity: under constant darkness, mice on a C57BL/6 congenic background exhibit prolonged activity periods compared with mice on a congenic BALB/cJ background

Allelic Composition	Clock^m1Jt/Clock⁺
Genetic Background	C57BL/6-Clock^m1Jt

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Clock^m1Jt mutation (3 available); any Clock mutation (104 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

abnormal behavior ( J:101849 )

• in a forced-swim test, female mice exhibit less immobility compared with wild-type mice but as much as in Clock^m1Jt homozygotes

• however, anxiety and depressive-like behavior are not increased

increased exploration in new environment ( J:101849 )

• during constant darkness in an open field, mice spend more time exploring the center than wild-type mice but as much as in Clock^m1Jt homozygotes

increased vertical activity ( J:101849 )

• in female mice in an open field test

prolonged circadian behavior period ( J:18005 , J:198519 )

• circadian period gradually lengthens over the first 39 days of constant darkness, with an average of 24.4 hours compared to 23.2 hours in wild-type (J:18005)

• increased 0.6 hr upon exposure to constant darkness (J:198519)

• Background Sensitivity: mice on a C57BL/6J isogenic background exhibit a longer activity period under constant darkness than mice on a (BALB/cJ x C57BL/6J)F1 or BALB/cJ congenic background (J:198519)

abnormal circadian behavior phase ( J:98343 )

• in constant darkness, mice exhibit a 1 hour increase in free-running rhythm of locomotor activity compared with wild-type mice

abnormal sleep duration ( J:65198 )

• mice spend 9% less time asleep during the entire 24 hour light dark cycle compared with wild-type mice

abnormal sleep pattern ( J:65198 )

• during the 12 hour dark phase, mice spend less time in non-REM sleep than wild-type mice

• during the 12 hour dark phase, REM sleep is shorter than in wild-type mice

Allelic Composition	Clock^m1Jt/Clock⁺
Genetic Background	involves: C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Clock^m1Jt mutation (3 available); any Clock mutation (104 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

homeostasis/metabolism

abnormal circulating protein level ( J:155089 )

• mice exhibit decreased plasminogen activator inhibitor-1 (PAI-1) levels compared with wild-type mice

• at zeitgeber time (ZT) 14, mice fail to exhibit a decreased in total plasma tissue plasminogen activator (tPA) levels compared with wild-type mice

abnormal response to injury ( J:155089 )

• diurnal variations in time to thrombotic vascular occlusion (TTVO) subsequent to photochemical injury observed in similarly treated wild-type mice

• TTVO subsequent to photochemical injury is increased at zeitgeber time (ZT) 14 compared with similarly treated wild-type mice

Allelic Composition	Clock^m1Jt/Clock^m1Jt Tg(BAC54)36Jt/0
Genetic Background	involves: BALB/cJ * C57BL/6 * C57BL/6J * CD-1

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Clock^m1Jt mutation (3 available); any Clock mutation (104 available)
Tg(BAC54)36Jt mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

behavior/neurological phenotype ( J:40363 )

N	• mice exhibit normal circadian periodicity and rhythm

Allelic Composition	Clock^m1Jt/Clock⁺ Usf1^soc/Usf1⁺
Genetic Background	(BALB/cJ x C57BL/6J)F1

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Clock^m1Jt mutation (3 available); any Clock mutation (104 available)
Usf1^soc mutation (0 available); any Usf1 mutation (81 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

prolonged circadian behavior period ( J:198519 )

• increased 0.3 hr upon exposure to constant darkness

• Background Sensitivity: mice on a (BALB/cJ x C57BL/6J)F1 background exhibit a shorted extension of activity period upon exposure to constant darkness compared with mice on a C57BL/6J congenic background

Allelic Composition	Clock^m1Jt/Clock⁺ Usf1^soc/Usf1^soc
Genetic Background	C.B6-Clock^m1Jt

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

behavior/neurological phenotype ( J:198519 )

N	• mice on a BALB/cJ congenic background exhibit normal activity period under constant darkness unlike mice on a C57BL/6J isogenic background

Allelic Composition	Clock^m1Jt/Clock⁺ Per2^tm1Jt/Per2⁺ Usf1^soc/?
Genetic Background	involves: 129S6/SvEvTac * BALB/cJ * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Clock^m1Jt mutation (3 available); any Clock mutation (104 available)
Per2^tm1Jt mutation (2 available); any Per2 mutation (73 available)
Usf1^soc mutation (0 available); any Usf1 mutation (81 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

abnormal circadian behavior period ( J:198519 )

• Background Sensitivity: shorter period compared to in mice on a background with more C57BL/6 contribution

Allelic Composition	Clock^m1Jt/Clock^m1Jt Lep^ob/Lep^ob
Genetic Background	involves: BALB/c * C57BL/6 * C57BL/6J * Jcl:ICR

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Clock^m1Jt mutation (3 available); any Clock mutation (104 available)
Lep^ob mutation (5 available); any Lep mutation (21 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

homeostasis/metabolism

decreased circulating glucose level ( J:135847 )

• compared to in Lep^ob homozygotes

increased circulating glucose level ( J:135847 )

• compared to in wild-type and Clock^m1Jt homozygotes

decreased circulating insulin level ( J:135847 )

• compared to in Lep^ob homozygotes

increased circulating insulin level ( J:135847 )

• compared to in wild-type and Clock^m1Jt homozygotes

increased circulating cholesterol level ( J:135847 )

• compared to in wild-type or single homozygotes

increased circulating free fatty acids level ( J:135847 )

• compared to in wild-type and Clock^m1Jt homozygotes

increased circulating triglyceride level ( J:135847 )

• compared to in wild-type or single homozygotes

adipose tissue

increased fat cell size ( J:135847 )

growth/size/body

increased body weight ( J:135847 )

• compared to in wild-type or single homozygotes

Allelic Composition	Clock^m1Jt/Clock⁺ Tg(CMV-Usf1)1Jt/0
Genetic Background	involves: C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Clock^m1Jt mutation (3 available); any Clock mutation (104 available)
Tg(CMV-Usf1)1Jt mutation (0 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

abnormal circadian behavior period ( J:198519 )

• shorter period compared to Clock^m1Jt heterozygotes

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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