Analysis Tools|
Allele Symbol Allele Name Allele ID |
Fanclgcd germ cell deficient MGI:1861640 |
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| Summary |
6 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• mutant embryos were observed at 9.5 dpc, but not at 10.5 dpc
• embryonic lethality was not observed on mixed backgrounds involving C57BL/6J and CBA/J or involving C57BL/6 and FVB
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• reduced embryonic weight on a mixed background involving C57BL/6 and FVB, however pups were of normal weight at birth
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• reduced embryonic weight on a mixed background involving C57BL/6 and FVB, however pups were of normal weight at birth
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
Histological sections of adult Fanclgcd/Fanclgcd mouse gonads
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• reduced complexity of uterine glands
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• only a few corpora lutea are detected at 2.5 and 5 months of age
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(J:13553)
• significant absence of developing follicles at 2.5 and 5 months of age
(J:21254)
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(J:13553)
• 80-90% reduction in mass relative to controls
(J:21254)
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• hemorrhagic cysts were observed
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• 50-70% of the tubules lacked all cells but sertioli, however normal weight and histology of seminal vesicles, coagulating glands, prostate, bulbourethral glands, and preputial glands
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• testicular mass was approximately 1/3 that of controls
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• hemorrhagic cysts were observed
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• sperm counts were 10% of those of wild-type
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• depletion evident at 10.25 dpc, when mice had approximatly 1/3 the primordial germ cells as wild-type
(J:80424)
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• reduced primordial germ cell (PGC) prolifertation
• normal PGC migration
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• 50-70% of the tubules lacked all cells but sertioli, however normal weight and histology of seminal vesicles, coagulating glands, prostate, bulbourethral glands, and preputial glands
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• testicular mass was approximately 1/3 that of controls
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• the female reproductive tract is pale, thin, and thread-like with a castrate appearance
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• reduced complexity of uterine glands
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• only a few corpora lutea are detected at 2.5 and 5 months of age
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(J:13553)
• significant absence of developing follicles at 2.5 and 5 months of age
(J:21254)
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(J:13553)
• 80-90% reduction in mass relative to controls
(J:21254)
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• hemorrhagic cysts were observed
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(J:13553)
• the thickness of the muscularis externa is significantly reduced
(J:21254)
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• 80-90% reduction in mass relative to controls
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• reduced thickness of serosa, myometrium, and endometrium
(J:13553)
• reduced complexity of uterine glands
(J:13553)
• 80-90% reduction in mass relative to controls
(J:21254)
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• epididymal mass was approximately 1/3 that of controls
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• reduced ovulation observed in prepubertal females after superovulation regime
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• no ovulation observed in postpubertal females after superovulation regime
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• females initially exhibit a normal 4-5 day cycle, but begin to cycle irregularly by 6-8 weeks of age
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• absence of oestrus cycling by 20 weeks of age
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• females are infertile, however mutant mice display normal sexual development in terms of sexual behavior and mammary gland histology
(J:13553)
• females are infertile however have normal timing of vaginal opening
(J:21254)
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• sperm counts were 10% of those of wild-type
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• depletion evident at 10.25 dpc, when mice had approximatly 1/3 the primordial germ cells as wild-type
(J:80424)
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• reduced primordial germ cell (PGC) prolifertation
• normal PGC migration
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Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
| 46 XX gonadal dysgenesis | DOID:14450 |
OMIM:PS233300 |
J:13553 | |
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• lethality on a 129/Sv background
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• lethality on a mixed background involving 129/Sv and C57BL/6
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• >90% of seminiferous tubules contained vacuolated sertoli cells
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• approximately 1/3 the size of wild-type
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• deficiency observed at 10.5 dpc
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• >90% of seminiferous tubules contained vacuolated sertoli cells
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• approximately 1/3 the size of wild-type
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• deficiency observed at 10.5 dpc
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 11/19/2024 MGI 6.24 |
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