Phenotypes associated with this allele

• Allele Symbol: Gsdma3^Rim3
• Allele Name: recombination induced mutation 3
• Allele ID: MGI:1861663
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Gsdma3^Rim3/Gsdma3^Rim3	involves: C57BL/10J * DBA/2J	MGI:4356110
ht2	Gsdma3^Rim3/Gsdma3^+	involves: C57BL/10J * DBA/2J	MGI:4356111

Genotype
MGI:4356110

hm1

• Allelic Composition: Gsdma3^Rim3/Gsdma3^Rim3
• Genetic Background: involves: C57BL/10J * DBA/2J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

vision/eye

disorganized cornea epithelium ( J:42692 )

• histological analysis of the center of the cornea of 3 month old mice reveals a disorganized epithelial layer

abnormal cornea stroma development ( J:42692 )

• lesions appear sooner than for heterozygotes

increased cornea stroma thickness ( J:42692 )

• obvious in histological sections of the center of the cornea from mice 3 months of age

cornea opacity ( J:42692 )

integument

decreased hair follicle number ( J:42692 )

• few hair follicles are seen in dorsal skin from mice 4.5 months of age

• homozygous and heterozygous mice look similar

abnormal epidermal layer morphology ( J:42692 )

hyperkeratosis ( J:42692 )

hypergranulosis ( J:42692 )

acanthosis ( J:42692 )

thick epidermis ( J:42692 )

• histological analysis shows dorsal skin is slightly thickened at 1 week of age; clearly thickened at 1 month of age

• no accompanying loss of hair follicles is seen at these ages

Genotype
MGI:4356111

ht2

• Allelic Composition: Gsdma3^Rim3/Gsdma3⁺
• Genetic Background: involves: C57BL/10J * DBA/2J

vision/eye

abnormal cornea epithelium morphology ( J:42692 )

• histological analysis of the center of the cornea from 3 month old mice reveals flat-shaped basal cells in the epithelium

abnormal cornea stroma development ( J:42692 )

cornea opacity ( J:42692 )

• at 5 months of age the phenotype is similar to mice heterozygous for Gsdma3^Re-den

integument

abnormal hair growth ( J:42692 )

sparse hair ( J:42692 )

• homozygous and heterozygous mice look similar

• at 5 months of age the phenotype is similar to mice heterozygous for Gsdma3^Re-den

decreased hair follicle number ( J:42692 )

• few hair follicles are seen in dorsal skin from mice 4.5 months of age

abnormal hair cycle ( J:122738 )

abnormal hair cycle anagen phase ( J:122738 )

• at the first hair cycle

abnormal epidermal layer morphology ( J:42692 )

hyperkeratosis ( J:42692 )

• seen in histological sections of dorsal skin of mice 4.5 months of age

hypergranulosis ( J:42692 )

acanthosis ( J:42692 )

thick epidermis ( J:42692 )

• revealed by histological analysis of dorsal skin from 4.5 month old mice