All Phenotypes Htt<tm3Mem> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Htt^tm3Mem
targeted mutation 3, Marcy E MacDonald
MGI:1861699

Summary

5 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Htt^tm3Mem/Htt^tm3Mem	involves: 129S1/Sv * 129X1/SvJ * C57BL/6	MGI:3698276
hm2	Htt^tm3Mem/Htt^tm3Mem	involves: 129S/SvEv * 129S1/Sv * 129X1/SvJ * CD-1	MGI:3698002
ht3	Htt^tm1Mem/Htt^tm3Mem	involves: 129S/SvEv * 129S1/Sv * 129X1/SvJ * CD-1	MGI:3698009
cx4	Fan1^em2Mem/Fan1^em2Mem Htt^tm3Mem/Htt⁺	involves: 129S1/Sv * 129X1/SvJ * C57BL/6J	MGI:6489858
cx5	Fan1^em2Mem/Fan1⁺ Htt^tm3Mem/Htt⁺	involves: 129S1/Sv * 129X1/SvJ * C57BL/6J	MGI:6489859

Allelic Composition	Htt^tm3Mem/Htt^tm3Mem
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Htt^tm3Mem mutation (1 available); any Htt mutation (178 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

nervous system phenotype ( J:99425 )

N	• unlike other Hdh alleles that are models for Huntington Disease, homozygotes show no change in striatal mitochondrial sensitivity to calcium in the brain, thus displaying normal striatal and cortical calcium sensitivity

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
NOT	Huntington's disease	DOID:12858	OMIM:143100	J:99425

Allelic Composition	Htt^tm3Mem/Htt^tm3Mem
Genetic Background	involves: 129S/SvEv * 129S1/Sv * 129X1/SvJ * CD-1

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Htt^tm3Mem mutation (1 available); any Htt mutation (178 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

normal phenotype

no abnormal phenotype detected ( J:44391 )

• homozygotes are indistinguishable from controls in appearance and behavior, or by gross and microscopic examination of the brain, at 6 months of age

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
NOT	Huntington's disease	DOID:12858	OMIM:143100	J:44391

Allelic Composition	Htt^tm1Mem/Htt^tm3Mem
Genetic Background	involves: 129S/SvEv * 129S1/Sv * 129X1/SvJ * CD-1

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Htt^tm1Mem mutation (1 available); any Htt mutation (178 available)
Htt^tm3Mem mutation (1 available); any Htt mutation (178 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

normal phenotype

no abnormal phenotype detected ( J:44391 )

• appear normal; none display abnormal behaviors at 6 months of age

Allelic Composition	Fan1^em2Mem/Fan1^em2Mem Htt^tm3Mem/Htt⁺
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fan1^em2Mem mutation (0 available); any Fan1 mutation (99 available)
Htt^tm3Mem mutation (1 available); any Htt mutation (178 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cellular

abnormal cell physiology ( J:298297 )

• some expansion of the Htt CAG triplet repeats in striatum and liver at 8 months of age

Allelic Composition	Fan1^em2Mem/Fan1⁺ Htt^tm3Mem/Htt⁺
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cellular

abnormal cell physiology ( J:298297 )

• expansion of the Htt CAG triplet repeats in striatum and liver at 8 months of age

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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