All Phenotypes Htt<tm2Mem> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Htt^tm2Mem
targeted mutation 2, Marcy E MacDonald
MGI:1861703

Summary

1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Htt^tm2Mem/Htt^tm2Mem	involves: 129S1/Sv * 129X1/SvJ * CD-1	MGI:3698279

Allelic Composition	Htt^tm2Mem/Htt^tm2Mem
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * CD-1

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Htt^tm2Mem mutation (2 available); any Htt mutation (178 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

nervous system phenotype ( J:99425 )

N	• unlike other Hdh alleles that are models for Huntington Disease, homozygotes show no change in striatal mitochondrial sensitivity to calcium in the brain, thus displaying normal striatal and cortical calcium sensitivity

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
NOT	Huntington's disease	DOID:12858	OMIM:143100	J:99425

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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