Phenotypes associated with this allele

• Allele Symbol: Igf1^tm2Ts
• Allele Name: targeted mutation 2, Timothy Stewart
• Allele ID: MGI:1861704
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Igf1^tm2Ts/Igf1^tm2Ts	involves: 129S7/SvEvBrd * C57BL/6J	MGI:2176936

Genotype
MGI:2176936

hm1

• Allelic Composition: Igf1^tm2Ts/Igf1^tm2Ts
• Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

growth/size/body

decreased body weight ( J:37969 )

• 36% reduction in adult body weight

• spleen, thymus, and heart are reduced proportionately to body weight, while brain, kidneys, liver and tibial length are less affected

cardiovascular system

increased heart left ventricle muscle contractility ( J:37969 )

• measurements of left ventricular contractility are increased, however the hypertrophic response of the left ventricular myocardium in response to aortic constriction is preserved

increased systemic arterial blood pressure ( J:37969 )

• elevation of mean arterial pressure, however heart rate is normal

increased systemic arterial diastolic blood pressure ( J:37969 )

increased systemic arterial systolic blood pressure ( J:37969 )

• increase in systolic pressure attains only borderline statistical significance

homeostasis/metabolism

decreased circulating glucose level ( J:37969 )

• serum glucose is significantly lower in young adults, however insulin resistance is not present at this age

decreased circulating growth hormone level ( J:37969 )

muscle

increased heart left ventricle muscle contractility ( J:37969 )

• measurements of left ventricular contractility are increased, however the hypertrophic response of the left ventricular myocardium in response to aortic constriction is preserved