Analysis Tools|
Allele Symbol Allele Name Allele ID |
Ntf3tm2Jae targeted mutation 2, Rudolf Jaenisch MGI:1861706 |
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| Summary |
9 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• no further reduction in proprioceptive sensory neuron survival is observed (with deletion of Ntf3); numbers in L5 DRG are reduced similarly to that observed in Etv1-deficient, Ntf3-sufficient animals
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• mice show a flexed posture when inverted, similar to Erbb2 conditional mutants
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• mice exhibit a wide-based, ataxic gait, similar to Erbb2 conditional mutants; onset of abnormalities is delayed and is less pronounced, however, relative to Erbb2 conditional animals
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| N |
• functional specificity of connections between afferents and motor neurons is preserved in conditional mutants
• anatomical specificity of connections between muscle afferents projecting to agonistic and antagonistic motor neurons is preserved in conditional mutants
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• at P5, ventral root potentials are normal, but by P14, amplitudes of potentials are reduced by >80% compared to controls
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• mice show a flexed posture when inverted, similar to Erbb2 and Ntf3;Egr3 conditional mutants
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• mice exhibit a wide-based, ataxic gait, similar to Erbb2 conditional mutants; onset of abnormalities is delayed and is less pronounced, however, relative to Erbb2 conditional animals
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• at P5, ventral root potentials are normal, but by P14, amplitudes of potentials are reduced by >75% compared to controls, similar to Ntf3;Egr3 conditional mutants
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• mice exhibit increased meal duration with reduced rate of food intake compared with control mice
• however, meal size is normal
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• mice exhibit increased meal duration with reduced rate of food intake compared with control mice
• mice exhibit a satiation deficit compared with control mice
• however, mice exhibit normal meal size and oropharyngeal-positive feedback signaling
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• mice exhibit reduced solitary tract nucleus and area postrema meal-induced c-Fos activation, suggesting a decrease in vagal afferent signaling, compared with control mice
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| N |
• mice exhibit normal body weight
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• at P8, cerebellar foliation is defective
• at P8, folium VII and the posterior superior fissure are absent
• however, the formation of cerebellum layers and their associations with specific cell types is normal
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• at P8, apoptotic rates are 75% higher (37.3+/-11.4 cells per mm2 compared to 21.3+/-6.98 cells per mm2 in wild-type mice)
• however, there is no increase in apoptotic cells in the external germinal layer
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• axonal projections of Ia afferents do not reach the spinal cord in E15.5 homozygotes
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• cleaved Casp3-positive (apoptotic) neurons are significantly elevated in number in dorsal root ganglia at E10.5 compared to control embryos
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• number of TrkC- or Runx3-positive proprioceptive neurons is decreased in the DRGs at E13.5 compared to heterozygous controls
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
| N |
• number of proprioceptive sensory neurons in L5 DRG is not affected relative to controls
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 11/05/2024 MGI 6.24 |
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