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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Vamp8Gt(OST20346)Lex
gene trap OST20346, Lexicon Genetics
MGI:1861709
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Vamp8Gt(OST20346)Lex/Vamp8Gt(OST20346)Lex involves: 129S5/SvEvBrd * C57BL/6 MGI:3775308


Genotype
MGI:3775308
hm1
Allelic
Composition
Vamp8Gt(OST20346)Lex/Vamp8Gt(OST20346)Lex
Genetic
Background
involves: 129S5/SvEvBrd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Vamp8Gt(OST20346)Lex mutation (1 available); any Vamp8 mutation (19 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• there is a significant reduction in beta-hexosamindase release by secretory granules of mast cells upon activation through the Fcepsilon receptor or by PMA/ionomycin incubation
• a similar reduction is observed for serotonin secretion
• Cathepsin D secretion is profoundly reduced by more than 80% upon activation through the Fcepsilon receptor
• TNF and histamine release from mast cells is not reduced upon activation through the Fcepsilon receptor

hematopoietic system
• there is a significant reduction in beta-hexosamindase release by secretory granules of mast cells upon activation through the Fcepsilon receptor or by PMA/ionomycin incubation
• a similar reduction is observed for serotonin secretion
• Cathepsin D secretion is profoundly reduced by more than 80% upon activation through the Fcepsilon receptor
• TNF and histamine release from mast cells is not reduced upon activation through the Fcepsilon receptor





Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
11/12/2024
MGI 6.24
The Jackson Laboratory