immune system
• there is a significant reduction in beta-hexosamindase release by secretory granules of mast cells upon activation through the Fcepsilon receptor or by PMA/ionomycin incubation
• a similar reduction is observed for serotonin secretion
• Cathepsin D secretion is profoundly reduced by more than 80% upon activation through the Fcepsilon receptor
• TNF and histamine release from mast cells is not reduced upon activation through the Fcepsilon receptor
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hematopoietic system
• there is a significant reduction in beta-hexosamindase release by secretory granules of mast cells upon activation through the Fcepsilon receptor or by PMA/ionomycin incubation
• a similar reduction is observed for serotonin secretion
• Cathepsin D secretion is profoundly reduced by more than 80% upon activation through the Fcepsilon receptor
• TNF and histamine release from mast cells is not reduced upon activation through the Fcepsilon receptor
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