integument
• skin-derived precursors isolated from E18 rudimentary dermis exhibit 3- to 4-fold more robust self-renewal and 4- to 5-fold more proliferation than wild-type cells
|
Allele Symbol Allele Name Allele ID |
Trp63tm1Brd targeted mutation 1, Allan Bradley MGI:1861713 |
||||||||||||
Summary |
2 genotypes
|
|
|
♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
• skin-derived precursors isolated from E18 rudimentary dermis exhibit 3- to 4-fold more robust self-renewal and 4- to 5-fold more proliferation than wild-type cells
|
|
|
♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
• death occurs within several hours of birth
|
• at E11.5
|
• small and misshapen at E11.5
|
• at E11.5
|
• small and misshapen at E11.5
|
• forelimbs truncated
|
• all are missing
|
• absent
|
• usually truncated, thinner than normal and deformed
|
• sometimes absent
|
• all are missing
|
• absent
|
• usually truncated, thinner than normal and deformed
|
• sometimes absent
|
• pelvic girdle usually present but lacking ossification centers
|
• "abnormal facies"
|
• water loss occurs 30X more rapidly than in controls, a skin permeability problem
|
• skin at birth totally lacks hair follicles
|
• reduced to a single layer of flattened cells
• epithelium of tongue and oral cavity is similar to the epidermis
|
• absent
|
• epidermal development apparently stops around E9.5
|
• water loss occurs 30X more rapidly than in controls, a skin permeability problem
|
• "abnormal facies"
|
Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
ectrodactyly, ectodermal dysplasia, and cleft lip-palate syndrome 3 | DOID:0060783 |
OMIM:604292 |
J:54636 |
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
||
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support. |
last database update 12/10/2024 MGI 6.24 |
|
|