Phenotypes associated with this allele

• Allele Symbol: Blmh^tm1Geh
• Allele Name: targeted mutation 1, Gregg E Homanics
• Allele ID: MGI:1861798
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Blmh^tm1Geh/Blmh^tm1Geh	either: (involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6J)	MGI:2658679

Genotype
MGI:2658679

hm1

• Allelic Composition: Blmh^tm1Geh/Blmh^tm1Geh
• Genetic Background: either: (involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6J)

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Gross appearance and histopathology of tail dermatitis on Blmh^tm1Geh/Blmh^tm1Geh mice

mortality/aging

increased susceptibility to xenobiotic induced morbidity/mortality ( J:54585 )

• bleomycin doses that were without effect in wild-type mice elicited lethality (50 or 100 mg/kg) in homozygous null mice

neonatal lethality, incomplete penetrance ( J:54585 )

• approximately 36% of homozygotes died as neonates; those surviving the neonatal period were fertile and appeared healthy

behavior/neurological

behavior/neurological phenotype ( J:54585 )

N • the skin lesions were not caused by aggressive behavior: both male and female mutants were housed individually without resolution of the tail dermatitis

cardiovascular system

cardiovascular system phenotype ( J:54585 )

N • homozygotes did not display angitis or vascular thrombosis

growth/size/body

decreased body size ( J:54585 )

• homozygotes frequently appeared smaller than wild-type or heterozygous littermates

homeostasis/metabolism

increased susceptibility to xenobiotic induced morbidity/mortality ( J:54585 )

• bleomycin doses that were without effect in wild-type mice elicited lethality (50 or 100 mg/kg) in homozygous null mice

increased physiological sensitivity to xenobiotic ( J:54585 )

• homozygotes were hypersensitive to the deleterious effects of bleomycin

• bleomycin doses that were without effect in wild-type mice elicited either pulmonary fibrosis (25 mg/kg) in homozygous null mice

limbs/digits/tail

abnormal tail morphology ( J:54585 )

• the gross tail lesions resembled rodent ringtail, and were frequently resolved by weaning

immune system

dermatitis ( J:54585 )

• dermatitis on the tail only

• mutants without dermatitis on the tail develop tail dermatitis when kept in a low-humidity atmosphere

integument

dermatitis ( J:54585 )

• dermatitis on the tail only

• mutants without dermatitis on the tail develop tail dermatitis when kept in a low-humidity atmosphere

thick epidermis ( J:54585 )

• similar to ringtail, the tail dermatitis included thickening of the epidermis (parakeratotic hyperkeratosis and acanthosis), areas of necrosis, and neutrophil infiltrate

• unlike ringtail, ballooning degeneration of the upper stratum spinosum and palor were observed in some mutant tails

scaly skin ( J:54585 )

• most newborns appeared normal except for a dermatopathy presenting initially as a mild ichthyosis with generalized scaling and sloughing of the skin over the entire body

• at ~7-10 days, the scaling became resolved except on the tail

• no abnormalities were observed in other tissues