Phenotypes associated with this allele

• Allele Symbol: Cdh6^tm1Sma
• Allele Name: targeted mutation 1, Steven P Mah
• Allele ID: MGI:1861807
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Cdh6^tm1Sma/Cdh6^tm1Sma	involves: 129S/SvEv * C57BL/6	MGI:3839662

Genotype
MGI:3839662

hm1

• Allelic Composition: Cdh6^tm1Sma/Cdh6^tm1Sma
• Genetic Background: involves: 129S/SvEv * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

renal/urinary system

abnormal kidney development ( J:63195 )

• formation of mesenchymally derived epithelial structures in explants is compromised compared to wild-type explants

• formation of polarized epithelia from kidney explants is reduced compared to wild-type explants

• kidney explants exhibit 40% fewer laminin+, mesenchymally derived structures compared to wild-type explants

• well-developed S-shaped structures are located farther from the tips of the ureteric buds and have laminin+ fibers separating the structures unlike in wild-type mice indicating non-continuous tubules

• 73.3% of ureteric buds are not fused to the mesenchymally derived epithelia compared to 21% in wild-type mice

• deposition of a well-defined basement membranes by mesenchyme aggregates in the developing kidney is impaired

• however, cellular proliferation within the developing kidney is normal

decreased nephron number ( J:63195 )

• adult mice have one third fewer nephrons than in wild-type mice due to postnatal necrotic loss

nephron necrosis ( J:63195 )

• at P1, 23% of nephrons are necrotic compared of 7% in wild-type nephrons

• necrosis of nephrons occurs shortly after the onset of filtration

• however, there is no apoptotic loss of nephrons