Phenotypes associated with this allele

• Allele Symbol: Cnga2^tm1Ngai
• Allele Name: targeted mutation 1, John Ngai
• Allele ID: MGI:1861912
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Cnga2^tm1Ngai/Cnga2^tm1Ngai	involves: 129S1/Sv * FVB/N	MGI:3717661
ot2	Cnga2^tm1Ngai/Y	involves: 129S1/Sv	MGI:3717665

Genotype
MGI:3717661

hm1

• Allelic Composition: Cnga2^tm1Ngai/Cnga2^tm1Ngai
• Genetic Background: involves: 129S1/Sv * FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

taste/olfaction

abnormal olfactory system physiology ( J:96894 )

♀ • lilial, octaldehyde, N-pentyl acetate, geraniol, citral, kovanol, valeric acid, ethyl priopionate, menthone, ethyl acetate and 1um forskolin fail to elicit an odor-evoked field potential at low concentration whereas a small response is elicited at high concentration (1-5mM)

♀ • 2,5-dimethyl pyrazine (DMP) and 2-heptanone activate a small number of glomeruli within the olfactory bulb

♀ • 1/40x 1% ethyl acetate activated 3 glomeruli distinct from those activated by DMP and 2-heptanone

abnormal olfaction ( J:96894 )

♀ • mice cannot detect lilial, octaldehyde, N-pentyl acetate and geraniol

Genotype
MGI:3717665

ot2

• Allelic Composition: Cnga2^tm1Ngai/Y
• Genetic Background: involves: 129S1/Sv

mortality/aging

postnatal lethality, complete penetrance ( J:36286 )

♂ • most male pups die 1 to 2 days after birth with empty stomachs from being unable to nurse and cannot locate mother's nipple even in the absence of competition from siblings

taste/olfaction

abnormal olfactory system physiology ( J:36286 )

♂ • 2-hexylpyridine, isomenthone, citrava, geraniol, pyrazine, lilial, ethyvanillin, and isovaleric fail to elicit an odorant-evoked potential

♂ • the odorant-evoked potential triggered by triethylamine is a rapidly rising positive potential

anosmia ( J:36286 )

♂ • general anosmia