Analysis Tools|
Allele Symbol Allele Name Allele ID |
Cux1tm1Ejn targeted mutation 1, Ellis J Neufeld MGI:1861916 |
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| Summary |
4 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• mice that survive weaning exhibit a reduced lifespan
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• 4% of weanlings are recovered compared to the expected 25% on a BALB/c background whereas no abnormal mortality is noted on a mixed background
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• 50% of pups born to homozygous mothers die during the postnatal period regardless of genotype
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• at P8 to P9, mice exhibit a slightly darker and less shiny coat than in wild-type mice
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• at P8 to P9, mice exhibit a slightly darker and less shiny coat than in wild-type mice
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• hair follicles are more deeply rooted and are mildly disorganized compared to in wild-type mice
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• at P2 with more subtle defects at P19
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• at P2 with more subtle defects at P19
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• mice develop kidney cysts at the same frequency as in Cys1cpk homozygotes but cysts are larger in size
• mice exhibit an increase in the number of advanced stage cysts compared to in Cys1cpk homozygotes
• cysts are primarily restricted to the collecting ducts with few proximal tubule cysts
• proliferation and apoptosis of cystic kidneys is increased compared to in Cys1cpk homozygotes
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• P10, kidneys are larger than in Cys1cpk homozygotes
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• at P3 and P10, kidney weight to body weight ratio is larger than in Cys1cpk homozygotes
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• compared to in Cys1cpk homozygotes at P10
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• mice develop kidney cysts at the same frequency as in Cys1cpk homozygotes but cysts are larger in size
• mice exhibit an increase in the number of advanced stage cysts compared to in Cys1cpk homozygotes
• cysts are primarily restricted to the collecting ducts with few proximal tubule cysts
• proliferation and apoptosis of cystic kidneys is increased compared to in Cys1cpk homozygotes
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• P10, kidneys are larger than in Cys1cpk homozygotes
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• at P3 and P10, kidney weight to body weight ratio is larger than in Cys1cpk homozygotes
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 12/10/2024 MGI 6.24 |
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