All Phenotypes Dab1<tm1Cpr> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Dab1^tm1Cpr
targeted mutation 1, Jonathan A Cooper
MGI:1861918

Summary

11 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Dab1^tm1Cpr/Dab1^tm1Cpr	either: (involves: 129S4/SvJaeSor * BALB/c) or (involves: 129S4/SvJaeSor * C57BL/6)	MGI:3722253
hm2	Dab1^tm1Cpr/Dab1^tm1Cpr	involves: 129S4/SvJaeSor	MGI:3810294
hm3	Dab1^tm1Cpr/Dab1^tm1Cpr	involves: 129S4/SvJaeSor * C57BL/6	MGI:3722182
hm4	Dab1^tm1Cpr/Dab1^tm1Cpr	involves: 129/Sv * C57BL/6	MGI:3050791
ht5	Dab1^tm1Cpr/Dab1^tm6Cpr	involves: 129S4/SvJaeSor * C57BL/6	MGI:3833856
ht6	Dab1^tm1Cpr/Dab1^tm2Cpr	involves: 129S4/SvJaeSor * C57BL/6	MGI:3722181
ht7	Dab1^tm1Cpr/Dab1^tm3.1Cpr	involves: 129S4/SvJaeSor * C57BL/6J	MGI:3810293
ht8	Dab1^tm1Cpr/Dab1^tm4Cpr	involves: 129/Sv * C57BL/6	MGI:3050789
cn9	Dab1^tm1Cpr/Dab1^tm1Cpr Rnf7^{tm1c(EUCOMM)Wtsi}/Rnf7^{tm1c(EUCOMM)Wtsi} Tg(Nes-cre)1Kln/0	involves: 129S4/SvJaeSor * C57BL/6 * C57BL/6N * SJL	MGI:5545906
cn10	Dab1^tm1Cpr/Dab1⁺ Rnf7^{tm1c(EUCOMM)Wtsi}/Rnf7^{tm1c(EUCOMM)Wtsi} Tg(Nes-cre)1Kln/0	involves: 129S4/SvJaeSor * C57BL/6 * C57BL/6N * SJL	MGI:5545907
cx11	Dab1^tm1Cpr/Dab1^tm4Cpr Reln^rl/Reln⁺	involves: 129/Sv * C3HeB/Fe * C57BL/6	MGI:3050790

Allelic Composition	Dab1^tm1Cpr/Dab1^tm1Cpr
Genetic Background	either: (involves: 129S4/SvJaeSor * BALB/c) or (involves: 129S4/SvJaeSor * C57BL/6)

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dab1^tm1Cpr mutation (1 available); any Dab1 mutation (79 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

abnormal neuronal precursor cell migration ( J:121846 )

• in vitro migration of neuroblasts and chain formation is disrupted

abnormal olfactory bulb morphology ( J:121846 )

• olfactory bulbs contain only 60% of the number of cells in the granule cell layer compared to in wild-type mice

• ependymal zone of the bulb contains fewer cells

abnormal rostral migratory stream morphology ( J:121846 )

• at P17 and P61, rostral migratory streams of (RMS) neuroblasts are severely disrupted and neuroblasts accumulate in the subventricular zone

abnormal olfactory bulb granule cell layer morphology ( J:121846 )

• fewer cells that contribute to the olfactory bulb are found in the granule cell layer

abnormal postnatal subventricular zone morphology ( J:121846 )

• neuroblasts and glial cells accumulate in the subventricular zone

• a 15-fold increase in apoptosis in the subventricular zone is observed

cellular

abnormal neuronal precursor cell migration ( J:121846 )

• in vitro migration of neuroblasts and chain formation is disrupted

Allelic Composition	Dab1^tm1Cpr/Dab1^tm1Cpr
Genetic Background	involves: 129S4/SvJaeSor

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dab1^tm1Cpr mutation (1 available); any Dab1 mutation (79 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

abnormal cortical marginal zone morphology ( J:74239 )

• the neocortical marginal zone is crowded with polymorphic cells unlike in wild-type mice

abnormal dentate gyrus morphology ( J:74239 )

• the dentate gyrus is disrupted

abnormal hippocampus pyramidal cell layer ( J:74239 )

• the pyramidal cells are scattered over a broad region unlike in wild-type mice

Allelic Composition	Dab1^tm1Cpr/Dab1^tm1Cpr
Genetic Background	involves: 129S4/SvJaeSor * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dab1^tm1Cpr mutation (1 available); any Dab1 mutation (79 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

premature death ( J:79475 )

• mice die at day 20 to 30 of unidentified causes

Allelic Composition	Dab1^tm1Cpr/Dab1^tm1Cpr
Genetic Background	involves: 129/Sv * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dab1^tm1Cpr mutation (1 available); any Dab1 mutation (79 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

abnormal cerebral cortex morphology ( J:91679 )

• the cortical layers are inverted

Allelic Composition	Dab1^tm1Cpr/Dab1^tm6Cpr
Genetic Background	involves: 129S4/SvJaeSor * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dab1^tm1Cpr mutation (1 available); any Dab1 mutation (79 available)
Dab1^tm6Cpr mutation (0 available); any Dab1 mutation (79 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

abnormal cortical marginal zone morphology ( J:145031 )

• absent

abnormal stratification in cerebral cortex ( J:145031 )

• disrupted order of neocortical layers

Allelic Composition	Dab1^tm1Cpr/Dab1^tm2Cpr
Genetic Background	involves: 129S4/SvJaeSor * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dab1^tm1Cpr mutation (1 available); any Dab1 mutation (79 available)
Dab1^tm2Cpr mutation (0 available); any Dab1 mutation (79 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

ataxia ( J:79475 )

• authors state that mice exhibit the same ataxic phenotype as Dab1^tm2Cpr homozygotes

Allelic Composition	Dab1^tm1Cpr/Dab1^tm3.1Cpr
Genetic Background	involves: 129S4/SvJaeSor * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dab1^tm1Cpr mutation (1 available); any Dab1 mutation (79 available)
Dab1^tm3.1Cpr mutation (0 available); any Dab1 mutation (79 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

nervous system phenotype ( J:74239 )

N	• mice exhibit a normal cerebellum and preplate splitting

abnormal neuronal migration ( J:74239 )

• late born neurons migrate into the marginal zone unlike in wild-type mice

abnormal cortical marginal zone morphology ( J:74239 )

• the neocortical marginal zone is thinner than in wild-type mice and crowded with small cells

abnormal hippocampus pyramidal cell layer ( J:74239 )

• mice exhibit a splitting of the stratum pyramidale in the CA1 region

• the ectopic pyramidal layer is closer to the hippocampal fissure, further from the alveus and becomes the main layer in the CA2 region

• however, the CA3 region and dentate gyrus develop normally

cellular

abnormal neuronal migration ( J:74239 )

• late born neurons migrate into the marginal zone unlike in wild-type mice

Allelic Composition	Dab1^tm1Cpr/Dab1^tm4Cpr
Genetic Background	involves: 129/Sv * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dab1^tm1Cpr mutation (1 available); any Dab1 mutation (79 available)
Dab1^tm4Cpr mutation (0 available); any Dab1 mutation (79 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

abnormal cortical marginal zone morphology ( J:91679 )

• the marginal zone of the cortex is reduced compared to mice heterozygous for either allele alone

• at E16.5 cortical plate neurons are more superficial than normal

Allelic Composition	Dab1^tm1Cpr/Dab1^tm1Cpr Rnf7^{tm1c(EUCOMM)Wtsi}/Rnf7^{tm1c(EUCOMM)Wtsi} Tg(Nes-cre)1Kln/0
Genetic Background	involves: 129S4/SvJaeSor * C57BL/6 * C57BL/6N * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dab1^tm1Cpr mutation (1 available); any Dab1 mutation (79 available)
Rnf7^{tm1c(EUCOMM)Wtsi} mutation (0 available); any Rnf7 mutation (17 available)
Tg(Nes-cre)1Kln mutation (4 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

abnormal cortical marginal zone morphology ( J:205551 )

• absent as in Dab1^tm1Cpr homozygotes

abnormal cortical plate morphology ( J:205551 )

• inverted cortical plate as in Dab1^tm1Cpr homozygotes

abnormal cerebellum development ( J:205551 )

• underdeveloped as in Dab1^tm1Cpr homozygotes

Allelic Composition	Dab1^tm1Cpr/Dab1⁺ Rnf7^{tm1c(EUCOMM)Wtsi}/Rnf7^{tm1c(EUCOMM)Wtsi} Tg(Nes-cre)1Kln/0
Genetic Background	involves: 129S4/SvJaeSor * C57BL/6 * C57BL/6N * SJL

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

nervous system phenotype ( J:205551 )

N	• Purkinje cell positioning and cerebellum size are rescued compared to in Rnf7^{tm1c(EUCOMM)Wtsi}/Rnf7^{tm1c(EUCOMM)Wtsi} Tg(Nes-cre)1Kln mice

Allelic Composition	Dab1^tm1Cpr/Dab1^tm4Cpr Reln^rl/Reln⁺
Genetic Background	involves: 129/Sv * C3HeB/Fe * C57BL/6

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

abnormal cortical marginal zone morphology ( J:91679 )

• the marginal zone of the cortex is reduced, similar to compound heterozygous mice wild-type for Reln

abnormal hippocampus morphology ( J:91679 )

• the hippocampus is subtly disorganized in the CA2/3 region compared to mice heterozygous for Dab1^tm1Cpr and Reln^rl

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