Phenotypes associated with this allele

• Allele Symbol: Gabrg2^tm1Geh
• Allele Name: targeted mutation 1, Gregg E Homanics
• Allele ID: MGI:1861927
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Gabrg2^tm1Geh/Gabrg2^tm1Geh	involves: 129S1/Sv * 129X1/SvJ * C57BL/6J	MGI:3835047
ht2	Gabrg2^tm1Geh/Gabrg2^+	involves: 129S1/Sv * 129X1/SvJ * C57BL/6J	MGI:3835048

Genotype
MGI:3835047

hm1

• Allelic Composition: Gabrg2^tm1Geh/Gabrg2^tm1Geh
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

abnormal GABA-mediated receptor currents ( J:53823 )

• GABA currents are more sensitive to inhibition by 5 uM zinc compared to in wild-type mice

• however, GABA currents are otherwise normal including sensitivity to midazolam and ethanol

homeostasis/metabolism

abnormal xenobiotic pharmacokinetics ( J:102772 )

• inhibition of flumazenil binding by midazolam, diazepam, and zolpidem is 10% to 14% greater than in wild-type mice while affinity towards betaCCM and Ro15-4513 is decreased 50% and 3-fold, respectively, compared to in wild-type mice

behavior/neurological

behavior/neurological phenotype ( J:53823 )

N • mice exhibit normal ethanol-induced ataxia, anxiolysis, hyperlocomotor activity, tolerance and dependence

N • mice exhibit normal balance on a rotarod

enhanced behavioral response to xenobiotic ( J:102772 )

• mice exhibit a 20% and 18% greater sleep time when exposed to midazolam and zolpidem, respectively, compared to similarly treated wild-type mice

• however, response to etomidate and pentobarbital is normal

Genotype
MGI:3835048

ht2

• Allelic Composition: Gabrg2^tm1Geh/Gabrg2⁺
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

reproductive system

reproductive system phenotype ( J:53823 )

N • female mice exhibit normal fertility

reduced male fertility ( J:53823 )

♂ • some mice exhibit reduced fertility while others are sterile