mortality/aging
• about 1/3 of mutant embryos are resorbed starting at E9.5
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Allele Symbol Allele Name Allele ID |
Gcktm1Efr targeted mutation 1, Shimon Efrat MGI:1861929 |
Summary |
2 genotypes |
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♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
• about 1/3 of mutant embryos are resorbed starting at E9.5
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|
|
♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
• heterozygotes exhibit abnormal hepatic glucose metabolism: hyperglycemia and hyperinsulinemia reduce hepatic glucose production by only 47% vs 72% in wild-type mice
• also, the fraction of hepatic UDPG pool derived from plasma glucose via the "direct" pathway is significantly reduced relative to wild-type
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• at 5-6 months, heterozygous males show normoglycemia in the fed state
• however, heterozygotes show a mild (25%) increase in overnight fasting glucose levels relative to wild-type mice
• in contrast, plasma insulin levels remain unchanged relative to wild-type in both the fed and fasted state
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• heterozygotes display reduced tolerance to glucose relative to wild-type mice
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Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
maturity-onset diabetes of the young type 2 | DOID:0111100 |
OMIM:125851 |
J:28756 |
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 08/21/2024 MGI 6.24 |
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