Phenotypes associated with this allele

• Allele Symbol: Il12rb2^tm1Jm
• Allele Name: targeted mutation 1, Jeanne Magram
• Allele ID: MGI:1861950
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Il12rb2^tm1Jm/Il12rb2^tm1Jm	B6;129S1-Il12rb2^tm1Jm/J	MGI:4834616
hm2	Il12rb2^tm1Jm/Il12rb2^tm1Jm	either: (involves: 129S1/Sv * BALB/cByJ) or (involves: 129S1/Sv * C57BL/6J)	MGI:2179461

Genotype
MGI:4834616

hm1

• Allelic Composition: Il12rb2^tm1Jm/Il12rb2^tm1Jm
• Genetic Background: B6;129S1-Il12rb2^tm1Jm/J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

increased circulating interleukin-12 level ( J:120061 )

immune system

salivary gland inflammation ( J:106805 )

• diffuse lymphocyte bundles

parotid gland inflammation ( J:106805 )

• inflammation

submandibular gland inflammation ( J:106805 )

• diffuse lymphocyte bundles

abnormal B cell activation ( J:106805 )

• B cells express high levels of the early activation marker CD69

abnormal T cell activation ( J:106805 )

• T cells express high levels of the early activation marker CD69

increased circulating interleukin-12 level ( J:120061 )

lymphoid hyperplasia ( J:106805 )

• CD138+ plasma-cell hyperplasia is observed in the spleen and lymph nodes

increased interleukin-6 secretion ( J:106805 )

• in spleen of 13 to 26 month old mice

increased anti-nuclear antigen antibody level ( J:106805 )

• development of secondary lymphoid follicles and CD138+plasma-cell hyperplasia is observed in the spleen and lymph nodes

liver inflammation ( J:106805 )

• diffuse lymphocyte bundles

glomerulonephritis ( J:106805 )

• mesangio-proliferative glomerulonephritis in 21 of 26 mice that first manifests at the age of 3 months and progresses with age

neoplasm

abnormal tumor vascularization ( J:120061 )

• microvessel density is significantly reduced in B16 melanoma derived tumors

abnormal tumor morphology ( J:120061 )

• characterized by a wide focus of ischemic-coagulative necrosis 17 days after B16 injection

• tumor cells have a significantly lower proliferation index and higher number of apoptotic cells 17 days after B16 injection than wild-type mice

decreased tumor growth/size ( J:120061 )

• decreased B16 melonama derived tumor size 17 days after subcutaneous injection

increased lung carcinoma incidence ( J:106805 )

• epithelial lung tumors such as bronchoalveolar carcinoma of the lung in older mice

increased plasmacytoma incidence ( J:106805 )

• 4 of 13 mice older than 12 months show mature plasmacytoma histologic features

cardiovascular system

abnormal tumor vascularization ( J:120061 )

• microvessel density is significantly reduced in B16 melanoma derived tumors

renal/urinary system

glomerulonephritis ( J:106805 )

• mesangio-proliferative glomerulonephritis in 21 of 26 mice that first manifests at the age of 3 months and progresses with age

hematopoietic system

abnormal B cell activation ( J:106805 )

• B cells express high levels of the early activation marker CD69

abnormal T cell activation ( J:106805 )

• T cells express high levels of the early activation marker CD69

liver/biliary system

liver inflammation ( J:106805 )

• diffuse lymphocyte bundles

digestive/alimentary system

salivary gland inflammation ( J:106805 )

• diffuse lymphocyte bundles

parotid gland inflammation ( J:106805 )

• inflammation

submandibular gland inflammation ( J:106805 )

• diffuse lymphocyte bundles

endocrine/exocrine glands

salivary gland inflammation ( J:106805 )

• diffuse lymphocyte bundles

parotid gland inflammation ( J:106805 )

• inflammation

submandibular gland inflammation ( J:106805 )

• diffuse lymphocyte bundles

respiratory system

increased lung carcinoma incidence ( J:106805 )

• epithelial lung tumors such as bronchoalveolar carcinoma of the lung in older mice

Genotype
MGI:2179461

hm2

• Allelic Composition: Il12rb2^tm1Jm/Il12rb2^tm1Jm
• Genetic Background: either: (involves: 129S1/Sv * BALB/cByJ) or (involves: 129S1/Sv * C57BL/6J)

immune system

abnormal lymphocyte physiology ( J:65891 )

• absence of IL12-stimulated IFNG production or proliferation in Con A-activated splenocytes; however, when stimulated with IL2 proliferation of splenocytes is similar to wild-type

• lymph node cells from keyhole limpet hemocyanin (KLH) immunized mice fail to produce IFNG when cultured with KLH

• secretion of IFNG in response to either anti-CD3 antibody or Con A stimulation is severely impaired

abnormal NK cell physiology ( J:65891 )

• natural killer lytic activity of splenocytes is enhanced in response to IL2 but not IL12

hematopoietic system

abnormal lymphocyte physiology ( J:65891 )

• absence of IL12-stimulated IFNG production or proliferation in Con A-activated splenocytes; however, when stimulated with IL2 proliferation of splenocytes is similar to wild-type

• lymph node cells from keyhole limpet hemocyanin (KLH) immunized mice fail to produce IFNG when cultured with KLH

• secretion of IFNG in response to either anti-CD3 antibody or Con A stimulation is severely impaired

abnormal NK cell physiology ( J:65891 )

• natural killer lytic activity of splenocytes is enhanced in response to IL2 but not IL12