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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Il12rb2tm1Jm
targeted mutation 1, Jeanne Magram
MGI:1861950
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Il12rb2tm1Jm/Il12rb2tm1Jm B6;129S1-Il12rb2tm1Jm/J MGI:4834616
hm2
 		Il12rb2tm1Jm/Il12rb2tm1Jm either: (involves: 129S1/Sv * BALB/cByJ) or (involves: 129S1/Sv * C57BL/6J) MGI:2179461


Genotype
MGI:4834616
hm1
Allelic
Composition		 Il12rb2tm1Jm/Il12rb2tm1Jm
Genetic
Background		 B6;129S1-Il12rb2tm1Jm/J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Il12rb2tm1Jm mutation (2 available); any Il12rb2 mutation (48 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
homeostasis/metabolism

immune system
salivary gland inflammation ( J:106805 )
• diffuse lymphocyte bundles
submandibular gland inflammation ( J:106805 )
• diffuse lymphocyte bundles
abnormal B cell activation ( J:106805 )
• B cells express high levels of the early activation marker CD69
abnormal T cell activation ( J:106805 )
• T cells express high levels of the early activation marker CD69
lymphoid hyperplasia ( J:106805 )
• CD138+ plasma-cell hyperplasia is observed in the spleen and lymph nodes
increased interleukin-6 secretion ( J:106805 )
• in spleen of 13 to 26 month old mice
increased anti-nuclear antigen antibody level ( J:106805 )
• development of secondary lymphoid follicles and CD138+plasma-cell hyperplasia is observed in the spleen and lymph nodes
liver inflammation ( J:106805 )
• diffuse lymphocyte bundles
glomerulonephritis ( J:106805 )
• mesangio-proliferative glomerulonephritis in 21 of 26 mice that first manifests at the age of 3 months and progresses with age

neoplasm
abnormal tumor vascularization ( J:120061 )
• microvessel density is significantly reduced in B16 melanoma derived tumors
abnormal tumor morphology ( J:120061 )
• characterized by a wide focus of ischemic-coagulative necrosis 17 days after B16 injection
• tumor cells have a significantly lower proliferation index and higher number of apoptotic cells 17 days after B16 injection than wild-type mice
decreased tumor growth/size ( J:120061 )
• decreased B16 melonama derived tumor size 17 days after subcutaneous injection
increased lung carcinoma incidence ( J:106805 )
• epithelial lung tumors such as bronchoalveolar carcinoma of the lung in older mice
increased plasmacytoma incidence ( J:106805 )
• 4 of 13 mice older than 12 months show mature plasmacytoma histologic features

cardiovascular system
abnormal tumor vascularization ( J:120061 )
• microvessel density is significantly reduced in B16 melanoma derived tumors

renal/urinary system
glomerulonephritis ( J:106805 )
• mesangio-proliferative glomerulonephritis in 21 of 26 mice that first manifests at the age of 3 months and progresses with age

hematopoietic system
abnormal B cell activation ( J:106805 )
• B cells express high levels of the early activation marker CD69
abnormal T cell activation ( J:106805 )
• T cells express high levels of the early activation marker CD69

liver/biliary system
liver inflammation ( J:106805 )
• diffuse lymphocyte bundles

digestive/alimentary system
salivary gland inflammation ( J:106805 )
• diffuse lymphocyte bundles
submandibular gland inflammation ( J:106805 )
• diffuse lymphocyte bundles

endocrine/exocrine glands
salivary gland inflammation ( J:106805 )
• diffuse lymphocyte bundles
submandibular gland inflammation ( J:106805 )
• diffuse lymphocyte bundles

respiratory system
increased lung carcinoma incidence ( J:106805 )
• epithelial lung tumors such as bronchoalveolar carcinoma of the lung in older mice




Genotype
MGI:2179461
hm2
Allelic
Composition		 Il12rb2tm1Jm/Il12rb2tm1Jm
Genetic
Background		 either: (involves: 129S1/Sv * BALB/cByJ) or (involves: 129S1/Sv * C57BL/6J)
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Il12rb2tm1Jm mutation (2 available); any Il12rb2 mutation (48 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal lymphocyte physiology ( J:65891 )
• absence of IL12-stimulated IFNG production or proliferation in Con A-activated splenocytes; however, when stimulated with IL2 proliferation of splenocytes is similar to wild-type
• lymph node cells from keyhole limpet hemocyanin (KLH) immunized mice fail to produce IFNG when cultured with KLH
• secretion of IFNG in response to either anti-CD3 antibody or Con A stimulation is severely impaired
abnormal NK cell physiology ( J:65891 )
• natural killer lytic activity of splenocytes is enhanced in response to IL2 but not IL12

hematopoietic system
abnormal lymphocyte physiology ( J:65891 )
• absence of IL12-stimulated IFNG production or proliferation in Con A-activated splenocytes; however, when stimulated with IL2 proliferation of splenocytes is similar to wild-type
• lymph node cells from keyhole limpet hemocyanin (KLH) immunized mice fail to produce IFNG when cultured with KLH
• secretion of IFNG in response to either anti-CD3 antibody or Con A stimulation is severely impaired
abnormal NK cell physiology ( J:65891 )
• natural killer lytic activity of splenocytes is enhanced in response to IL2 but not IL12




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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11/12/2024
MGI 6.24 		The Jackson Laboratory