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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Il4ratm1Sz
targeted mutation 1, Leonard Shultz
MGI:1861951
Summary 5 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Il4ratm1Sz/Il4ratm1Sz BALB/c-Il4ratm1Sz MGI:3844327
hm2
 		Il4ratm1Sz/Il4ratm1Sz BALB/c-Il4ratm1Sz/J MGI:2179965
cn3
 		Il4ratm1Sz/Il4ratm1Sz
Il7rtm1.1Asin/Il7rtm1Imx
Tg(Cd8a*-cre)B8Asin/0 		involves: 129S7/SvEvBrd * BALB/cJ * C57BL/6 MGI:5469008
cx4
 		Fbn1Tsk/Fbn1+
Il4ratm1Sz/Il4ratm1Sz 		involves: BALB/cJ * C57BL/6J * C57BL/10 * DBA/2 MGI:3800675
cx5
 		Fbn1Tsk/Fbn1+
Il4ratm1Sz/Il4ra+ 		involves: BALB/cJ * C57BL/6J * C57BL/10 * DBA/2 MGI:3800676


Genotype
MGI:3844327
hm1
Allelic
Composition		 Il4ratm1Sz/Il4ratm1Sz
Genetic
Background		 BALB/c-Il4ratm1Sz
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Il4ratm1Sz mutation (2 available); any Il4ra mutation (46 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
increased IgG2a level ( J:110429 )
• mice make increased levels of IgG2 in response to N. brasiliensis infection
increased susceptibility to parasitic infection ( J:110429 )
• 15 days after inoculation with N. brasiliensis, intestines contain large numbers of adult worms while controls have expelled the worms by this time point

hematopoietic system
increased IgG2a level ( J:110429 )
• mice make increased levels of IgG2 in response to N. brasiliensis infection




Genotype
MGI:2179965
hm2
Allelic
Composition		 Il4ratm1Sz/Il4ratm1Sz
Genetic
Background		 BALB/c-Il4ratm1Sz/J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Il4ratm1Sz mutation (2 available); any Il4ra mutation (46 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal microglial cell morphology ( J:125605 )
• microglial cells fail to express the cell marker Ym1 (Chi3l3)
decreased IgE level ( J:43656 )
• lower circulating levels of IgE in normal and bacterial infected mice
decreased IgG1 level ( J:43656 )
• lower circulating levels in normal and bacterial infected mice
abnormal T-helper 2 physiology ( J:43656 )
• mice are unable to mount an effective Th2 response to N. brasiliensis bacteria as determined by Th2 cyotkine production by T cells
decreased interleukin-10 secretion ( J:43656 )
• decrease production by T cells from mice infected with N. brasiliensis bacteria
decreased interleukin-4 secretion ( J:43656 )
• decrease production of IL-4 by T cells from mice infected with N. brasiliensis bacteria
decreased interleukin-5 secretion ( J:43656 )
• decrease production of IL-5 by T cells from mice infected with N. brasiliensis bacteria
abnormal susceptibility to infection ( J:131994 )
• mice immunized with recombinant vvG (vaccinia virus expressing the G protein of respiratory syncytial virus (RSV)) then challenged with RSV display lower percentages and total numbers of eosinophils in the bronchoalveolar lavage (BAL) compared to wild-type mice

hematopoietic system
abnormal microglial cell morphology ( J:125605 )
• microglial cells fail to express the cell marker Ym1 (Chi3l3)
decreased IgE level ( J:43656 )
• lower circulating levels of IgE in normal and bacterial infected mice
decreased IgG1 level ( J:43656 )
• lower circulating levels in normal and bacterial infected mice
abnormal T-helper 2 physiology ( J:43656 )
• mice are unable to mount an effective Th2 response to N. brasiliensis bacteria as determined by Th2 cyotkine production by T cells

nervous system
abnormal microglial cell morphology ( J:125605 )
• microglial cells fail to express the cell marker Ym1 (Chi3l3)




Genotype
MGI:5469008
cn3
Allelic
Composition		 Il4ratm1Sz/Il4ratm1Sz
Il7rtm1.1Asin/Il7rtm1Imx
Tg(Cd8a*-cre)B8Asin/0
Genetic
Background		 involves: 129S7/SvEvBrd * BALB/cJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Il4ratm1Sz mutation (2 available); any Il4ra mutation (46 available)
Il7rtm1.1Asin mutation (1 available); any Il7r mutation (31 available)
Il7rtm1Imx mutation (4 available); any Il7r mutation (31 available)
Tg(Cd8a*-cre)B8Asin mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased CD8-positive, alpha-beta T cell number ( J:190889 )
• in the thymus, as in Il7rtm1.1Asin/Il7rtm1Imx Tg(Cd8a*-cre)#Asin mice

hematopoietic system
decreased CD8-positive, alpha-beta T cell number ( J:190889 )
• in the thymus, as in Il7rtm1.1Asin/Il7rtm1Imx Tg(Cd8a*-cre)#Asin mice




Genotype
MGI:3800675
cx4
Allelic
Composition		 Fbn1Tsk/Fbn1+
Il4ratm1Sz/Il4ratm1Sz
Genetic
Background		 involves: BALB/cJ * C57BL/6J * C57BL/10 * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fbn1Tsk mutation (2 available); any Fbn1 mutation (173 available)
Il4ratm1Sz mutation (2 available); any Il4ra mutation (46 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
respiratory system
overexpanded pulmonary alveolus ( J:68448 )
• enlarged alveoli and a histologic picture of emphysema are found, similar to that seen in tight skin heterozygotes with normal IL4RA expression

immune system
immune system phenotype ( J:68448 )
N
• unlike tight skin mice, these compound mutants do not develop autoantibodies against the scleroderma antigens topoisomerase I and fibrillin 1

integument
integument phenotype ( J:68448 )
N
• the cutaneous hyperplasia found in tight skin heterozygotes is diminished in these compound mutants and the thickness of the skin is normal
abnormal cutaneous collagen fibril morphology ( J:68448 )
• electron micrographs of skin show a predominance of abnormally small diameter collagen fibers, although there is reduced fibrotic development compared with tight skin mice with wildtype expression of IL4RA

Mouse Models of Human Disease
 DO ID OMIM ID(s) Ref(s)
pulmonary emphysema DOID:9675 OMIM:130700
 J:68448




Genotype
MGI:3800676
cx5
Allelic
Composition		 Fbn1Tsk/Fbn1+
Il4ratm1Sz/Il4ra+
Genetic
Background		 involves: BALB/cJ * C57BL/6J * C57BL/10 * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fbn1Tsk mutation (2 available); any Fbn1 mutation (173 available)
Il4ratm1Sz mutation (2 available); any Il4ra mutation (46 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
respiratory system
overexpanded pulmonary alveolus ( J:68448 )
• enlarged alveoli and a histologic picture of emphysema are found, similar to that seen in tight skin heterozygotes that are wildtype for Il4ra

immune system
increased autoantibody level ( J:68448 )
• increased anti-topoisomerase antibodies relative to wildtype, but lower than in tight skin mice wildtype for Il4ra

integument
thick skin ( J:68448 )
• the skin is as thick as tight skin heterozygotes wildtype for Il4ra

Mouse Models of Human Disease
 DO ID OMIM ID(s) Ref(s)
pulmonary emphysema DOID:9675 OMIM:130700
 J:68448




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory