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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Itgb7tm1Cgn
targeted mutation 1, University of Cologne
MGI:1861953
Summary 4 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Itgb7tm1Cgn/Itgb7tm1Cgn C57BL/6-Itgb7tm1Cgn/J MGI:3764689
hm2
Itgb7tm1Cgn/Itgb7tm1Cgn involves: C57BL/6 MGI:2180884
cn3
Itgavtm1Blb/Itgavtm1Blb
Itgb1tm1Ref/Itgb1tm1Ref
Itgb2tm2Bay/Itgb2tm2Bay
Itgb7tm1Cgn/Itgb7tm1Cgn
Tg(Mx1-cre)1Cgn/0
involves: 129S1/Sv * 129S7/SvEvBrd * 129X1/SvJ * C57BL/6 * CBA MGI:4358370
cx4
Itgb7tm1Cgn/Itgb7tm1Cgn
Tnftm2Gkl/Tnf+
involves: 129S/SvEv * C57BL/6 MGI:3799636


Genotype
MGI:3764689
hm1
Allelic
Composition
Itgb7tm1Cgn/Itgb7tm1Cgn
Genetic
Background
C57BL/6-Itgb7tm1Cgn/J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Itgb7tm1Cgn mutation (3 available); any Itgb7 mutation (72 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• labeled splenocytes have greatly reduced migration rates to the small and large intestine after intravenous injection into congenic hosts
• only a mild form of colitis develops when nave CD4 T cells from these mice are transferred to immunocompromised mice as opposed to the robust colitis that occurs when the T cells come from wild-type mice
• the number of transferred T cells found in the large intestine is reduced by two-thirds

digestive/alimentary system
• only a mild form of colitis develops when nave CD4 T cells from these mice are transferred to immunocompromised mice as opposed to the robust colitis that occurs when the T cells come from wild-type mice
• the number of transferred T cells found in the large intestine is reduced by two-thirds

cellular
• labeled splenocytes have greatly reduced migration rates to the small and large intestine after intravenous injection into congenic hosts

hematopoietic system
• labeled splenocytes have greatly reduced migration rates to the small and large intestine after intravenous injection into congenic hosts




Genotype
MGI:2180884
hm2
Allelic
Composition
Itgb7tm1Cgn/Itgb7tm1Cgn
Genetic
Background
involves: C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Itgb7tm1Cgn mutation (3 available); any Itgb7 mutation (72 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
N
• eosinophilic response to DSS treatment is normal
• uterine NK cells are smaller than in wild-type mice at day 10 of gestation (20 to 25 um compared to 30 um in wild-type mice)
• a slight increase in uterine NK cells of 144% is present in the decidua basalis
• 4eosinophil numbers are lower upon infection by T. spiralis compared to wild-type mice; eosinophilia is delayed and reduced in Itgb7-deficient mice
• mast cell numbers are lower upon infection by T. spiralis compared to wild-type; mastocytosis is reduced and delayed in Itgb7-deficient mice
• the number of IgA+ and IgM+ B cells and plasma cells are decreased 10 to 30-fold
• number of IgM+ cells in the Peyer's patches is decreased compared to in wild-type mice
• the number of CD4+ cells in the lamina propria is decreased compared to in wild-type mice
• mice exhibit hypoplasia of gut-associated lymphoid tissue
• rudimentary follicles do not disrupt the contour of the intestinal wall
• microscopically, Peyer's patches are reduced to 10 to 20% of wild-type despite having an increased bacterial load compared to wild-type mice
• the cellularity of Peyer's patches is reduced
• however, the number of Peyer's patches is normal
• leukocyte rolling velocity in high endothelial venules of Peyer's patches increased compared to in wild-type mice
• leukocyte rolling and adhesion are defective
• lymphocyte migration into Peyer's patches is almost abolished and is reduced by 49% in mesenteric lymph nodes compared to in wild-type mice
• worm expulsion is impaired (delayed) in null mice
• when primed mesenteric lymph node cells are transferred into infected wild-type mice, recipients receiving wild-type cells show significantly enhanced worm expulsion compared to those receiving Itgb7-deficient MLN cells
• when wild-type or null primed mesenteric lymph node cells are transferred into knockout recipients which are infected 1 day later, there is no protective effect conferred by wild-type cells compared to Itgb7-deficient cells

reproductive system
• uterine NK cells are smaller than in wild-type mice at day 10 of gestation (20 to 25 um compared to 30 um in wild-type mice)
• a slight increase in uterine NK cells of 144% is present in the decidua basalis
• while a typical metrial gland is not observed at E10, mice possess thickened myometrium with some PAS-reactive uterine NK cells
• at E14 implantation sites are poorly organized, a metrial gland develops but contains more smooth muscle fibers and fewer uterine NK cells than in wild-type mice

embryo
• trophoblast giant cells are increased in number compared to in wild-type mice
• uterine NK cells are smaller than in wild-type mice at day 10 of gestation (20 to 25 um compared to 30 um in wild-type mice)
• a slight increase in uterine NK cells of 144% is present in the decidua basalis

hematopoietic system
• leukocyte rolling velocity in high endothelial venules of Peyer's patches increased compared to in wild-type mice
• leukocyte rolling and adhesion are defective
• uterine NK cells are smaller than in wild-type mice at day 10 of gestation (20 to 25 um compared to 30 um in wild-type mice)
• a slight increase in uterine NK cells of 144% is present in the decidua basalis
• 4eosinophil numbers are lower upon infection by T. spiralis compared to wild-type mice; eosinophilia is delayed and reduced in Itgb7-deficient mice
• mast cell numbers are lower upon infection by T. spiralis compared to wild-type; mastocytosis is reduced and delayed in Itgb7-deficient mice
• the number of IgA+ and IgM+ B cells and plasma cells are decreased 10 to 30-fold
• number of IgM+ cells in the Peyer's patches is decreased compared to in wild-type mice
• the number of CD4+ cells in the lamina propria is decreased compared to in wild-type mice
• lymphocyte migration into Peyer's patches is almost abolished and is reduced by 49% in mesenteric lymph nodes compared to in wild-type mice

cellular
• leukocyte rolling velocity in high endothelial venules of Peyer's patches increased compared to in wild-type mice
• leukocyte rolling and adhesion are defective

endocrine/exocrine glands
• uterine NK cells are smaller than in wild-type mice at day 10 of gestation (20 to 25 um compared to 30 um in wild-type mice)
• a slight increase in uterine NK cells of 144% is present in the decidua basalis




Genotype
MGI:4358370
cn3
Allelic
Composition
Itgavtm1Blb/Itgavtm1Blb
Itgb1tm1Ref/Itgb1tm1Ref
Itgb2tm2Bay/Itgb2tm2Bay
Itgb7tm1Cgn/Itgb7tm1Cgn
Tg(Mx1-cre)1Cgn/0
Genetic
Background
involves: 129S1/Sv * 129S7/SvEvBrd * 129X1/SvJ * C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Itgavtm1Blb mutation (0 available); any Itgav mutation (54 available)
Itgb1tm1Ref mutation (0 available); any Itgb1 mutation (60 available)
Itgb2tm2Bay mutation (3 available); any Itgb2 mutation (50 available)
Itgb7tm1Cgn mutation (3 available); any Itgb7 mutation (72 available)
Tg(Mx1-cre)1Cgn mutation (7 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
N
• following pIpC-induction, dendritic cells transplanted into the footpad exhibit normal drainage into lymph nodes
• abolished in pIpC-induced mice
• following pIpC-induction, dendritic cells fail to adhere to and migrate on a 2-D substrate unlike wild-type dendritic cells
• however, dendritic cells from pIpC-induced mice exhibit normal migration in 3D matrix

cellular
• abolished in pIpC-induced mice

hematopoietic system
• abolished in pIpC-induced mice




Genotype
MGI:3799636
cx4
Allelic
Composition
Itgb7tm1Cgn/Itgb7tm1Cgn
Tnftm2Gkl/Tnf+
Genetic
Background
involves: 129S/SvEv * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Itgb7tm1Cgn mutation (3 available); any Itgb7 mutation (72 available)
Tnftm2Gkl mutation (1 available); any Tnf mutation (48 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• significant attenuation of the inflammatory bowel disease pathology with reduced acute and chronic inflammatory indices relative to mice heterozygous for Tnftm2Gkl alone
• chronic inflammatory arthritis is similar to mice heterozygous for Tnftm2Gkl alone

skeleton
• chronic inflammatory arthritis is similar to mice heterozygous for Tnftm2Gkl alone





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last database update
11/12/2024
MGI 6.24
The Jackson Laboratory