All Phenotypes Inhba<tm1Zuk> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Inhba^tm1Zuk
targeted mutation 1, Martin M Matzuk
MGI:1861957

Summary

10 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Inhba^tm1Zuk/Inhba^tm1Zuk	either: (129S/SvEv-Inhba^tm1Zuk) or (involves: 129S7/SvEvBrd * C57BL/6)	MGI:2180163
hm2	Inhba^tm1Zuk/Inhba^tm1Zuk	involves: 129S7/SvEvBrd	MGI:3771571
ht3	Inhba^tm1Zuk/Inhba⁺	B6.129S7-Inhba^tm1Zuk	MGI:5319780
ht4	Inhba^tm1Zuk/Inhba^tm2Zuk	involves: 129S7/SvEvBrd	MGI:3758909
cn5	Inhba^tm1Zuk/Inhba^tm3Zuk Inhbb^tm1Jae/Inhbb^tm1Jae Amhr2^tm3(cre)Bhr/Amhr2⁺	involves: 129S4/SvJae * 129S7/SvEvBrd * C57BL/6J	MGI:3758888
cn6	Amhr2^tm3(cre)Bhr/Amhr2⁺ Inhba^tm1Zuk/Inhba^tm3Zuk	involves: 129S7/SvEvBrd * C57BL/6J	MGI:3758887
cn7	Inhba^tm1Zuk/Inhba^tm3Zuk Tg(EIIa-cre)C5379Lmgd/?	involves: 129S7/SvEvBrd * C57BL/6J * FVB/N	MGI:3758885
cx8	Inhba^tm1Zuk/Inhba⁺ Inhbb^tm1Jae/Inhbb^tm1Jae	involves: 129S4/SvJae * 129S7/SvEvBrd	MGI:3758890
cx9	Inhba^tm1Zuk/Inhba^tm1Zuk Inhbb^tm1Jae/Inhbb^tm1Jae	involves: 129S4/SvJae * 129S7/SvEvBrd * C57BL/6	MGI:2180166
cx10	Inhba^tm1Zuk/Inhba^tm3Zuk Inhbb^tm1Jae/Inhbb^tm1Jae	involves: 129S4/SvJae * 129S7/SvEvBrd * C57BL/6J	MGI:3758893

Allelic Composition	Inhba^tm1Zuk/Inhba^tm1Zuk
Genetic Background	either: (129S/SvEv-Inhba^tm1Zuk) or (involves: 129S7/SvEvBrd * C57BL/6)

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Inhba^tm1Zuk mutation (2 available); any Inhba mutation (31 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

neonatal lethality, complete penetrance ( J:23923 )

• mice die within 24 hours of birth

craniofacial

abnormal alveolar process morphology ( J:23923 )

• mice display a secondary defect in the alveolar ridge of the mandible

absent incisors ( J:23923 )

absent lower incisors ( J:23923 )

• lower incisors are completely absent from 22 of 25 mice

absent hard palate ( J:23923 )

• Background Sensitivity: 7 of 22 mice (32%) on a mixed background that do not display a cleft palate lack a hard palate

cleft secondary palate ( J:23923 )

• Background Sensitivity: 12 of 42 (29%) of mice on a mixed background while 3 of 9 (33%) of mice on an inbred background have a cleft in the secondary palate

behavior/neurological

absent suckling reflex ( J:23923 )

skeleton

abnormal alveolar process morphology ( J:23923 )

• mice display a secondary defect in the alveolar ridge of the mandible

absent incisors ( J:23923 )

absent lower incisors ( J:23923 )

• lower incisors are completely absent from 22 of 25 mice

digestive/alimentary system

absent hard palate ( J:23923 )

• Background Sensitivity: 7 of 22 mice (32%) on a mixed background that do not display a cleft palate lack a hard palate

cleft secondary palate ( J:23923 )

• Background Sensitivity: 12 of 42 (29%) of mice on a mixed background while 3 of 9 (33%) of mice on an inbred background have a cleft in the secondary palate

integument

abnormal vibrissa follicle morphology ( J:23923 )

• growth and/or differentiation of whisker follicles is delayed

• if present, the root sheath is immature

• cells at the base of the hair bulb are irregular in pattern

• papilla lies closer to the surface

absent vibrissae ( J:23923 )

• mice are born without vibrissae

growth/size/body

abnormal alveolar process morphology ( J:23923 )

• mice display a secondary defect in the alveolar ridge of the mandible

absent incisors ( J:23923 )

absent lower incisors ( J:23923 )

• lower incisors are completely absent from 22 of 25 mice

absent hard palate ( J:23923 )

• Background Sensitivity: 7 of 22 mice (32%) on a mixed background that do not display a cleft palate lack a hard palate

cleft secondary palate ( J:23923 )

• Background Sensitivity: 12 of 42 (29%) of mice on a mixed background while 3 of 9 (33%) of mice on an inbred background have a cleft in the secondary palate

Allelic Composition	Inhba^tm1Zuk/Inhba^tm1Zuk
Genetic Background	involves: 129S7/SvEvBrd

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Inhba^tm1Zuk mutation (2 available); any Inhba mutation (31 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

Cellular defects in the epididymides of the Inhba^tm1Zuk/Inhba^tm1Zuk mouse

reproductive system

abnormal epididymis morphology ( J:122819 )

• epididymis fails to develop the characteristic coiling in the epithelium

• however, testosterone production and action is normal

abnormal epididymis epithelium morphology ( J:122819 )

• the typical increase in proliferation of cells in the Wolffian duct epithelium as it transforms into the epididymis from E15.5 to E19.5 is absent in mutants

embryo

abnormal Wolffian duct morphology ( J:122819 )

• Wolffian duct fails to elongate and coil, leaving a straight duct in the mesonephros

• the epithelial layer of the Wolffian duct becomes high columnar in shape compared to high cuboidal to low columnar in wild-type, and cell width decreases as the epithelial layer becomes crowded

• mesenchymal cells surrounding the duct are condensed and disorganized

Allelic Composition	Inhba^tm1Zuk/Inhba⁺
Genetic Background	B6.129S7-Inhba^tm1Zuk

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Inhba^tm1Zuk mutation (2 available); any Inhba mutation (31 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

muscle

increased quadriceps weight ( J:182827 )

• in males and females

increased gastrocnemius weight ( J:182827 )

• in males and females

increased skeletal muscle weight ( J:182827 )

• increased triceps weight in males and females

abnormal pectoral muscle morphology ( J:182827 )

• increased weight in males and females

growth/size/body

increased body weight ( J:182827 )

• in males

limbs/digits/tail

increased quadriceps weight ( J:182827 )

• in males and females

increased gastrocnemius weight ( J:182827 )

• in males and females

Allelic Composition	Inhba^tm1Zuk/Inhba^tm2Zuk
Genetic Background	involves: 129S7/SvEvBrd

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Inhba^tm1Zuk mutation (2 available); any Inhba mutation (31 available)
Inhba^tm2Zuk mutation (1 available); any Inhba mutation (31 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

premature death ( J:63882 )

• mice become cachectic and die between 3 and 4 weeks

reproductive system

decreased mature ovarian follicle number ( J:63882 )

• in adult mice the number of preovulatory follicles is reduced compared to in wild-type mice

decreased secondary ovarian follicle number ( J:63882 )

• ovaries contain fewer preantral follicles than in Inhba^tm2Zuk heterozygotes

small ovary ( J:63882 )

abnormal seminiferous tubule morphology ( J:63882 )

• differentiation of the seminiferous tubules is delayed

decreased testis weight ( J:63882 )

• testis weight is decreased more substantially than in Inhba^tm2Zuk homozygotes

large penis ( J:63882 )

enlarged clitoris ( J:63882 )

• female mice have prominent os clitori

enlarged external male genitalia ( J:63882 )

• some males have enlarged external genitalia and retracted foreskin

homeostasis/metabolism

hypoglycemia ( J:63882 )

• blood glucose level is reduced to 78.4+/-8 mg/dl compared to 129+/-7.8 mg/dl in wild-type mice

decreased circulating estradiol level ( J:63882 )

increased circulating follicle stimulating hormone level ( J:63882 )

• serum follicle stimulating hormone levels are 50% higher than those of wild-type mice

decreased circulating progesterone level ( J:63882 )

• serum progesterone levels are less than 50% of those in wild-type mice

hematopoietic system

anemia ( J:63882 )

• mild to moderate

decreased hematocrit ( J:63882 )

• 36+/-1.0% compared to 44+/-0.7% in wild-type mice

vision/eye

enophthalmos ( J:63882 )

growth/size/body

cachexia ( J:63882 )

endocrine/exocrine glands

decreased mature ovarian follicle number ( J:63882 )

• in adult mice the number of preovulatory follicles is reduced compared to in wild-type mice

decreased secondary ovarian follicle number ( J:63882 )

• ovaries contain fewer preantral follicles than in Inhba^tm2Zuk heterozygotes

small ovary ( J:63882 )

abnormal seminiferous tubule morphology ( J:63882 )

• differentiation of the seminiferous tubules is delayed

decreased testis weight ( J:63882 )

• testis weight is decreased more substantially than in Inhba^tm2Zuk homozygotes

renal/urinary system

large penis ( J:63882 )

craniofacial

craniofacial phenotype ( J:63882 )

N	• mice have normal palate and tooth development

integument

integument phenotype ( J:63882 )

N	• mice have normal whisker development

retarded hair growth ( J:63882 )

sparse hair ( J:63882 )

• female mice have sparse perigenital hair

rough coat ( J:63882 )

Allelic Composition	Inhba^tm1Zuk/Inhba^tm3Zuk Inhbb^tm1Jae/Inhbb^tm1Jae Amhr2^tm3(cre)Bhr/Amhr2⁺
Genetic Background	involves: 129S4/SvJae * 129S7/SvEvBrd * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Amhr2^tm3(cre)Bhr mutation (1 available); any Amhr2 mutation (29 available)
Inhba^tm1Zuk mutation (2 available); any Inhba mutation (31 available)
Inhba^tm3Zuk mutation (1 available); any Inhba mutation (31 available)
Inhbb^tm1Jae mutation (3 available); any Inhbb mutation (24 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cellular

absent oocytes ( J:125354 )

• 2 of 4 females produce no oocytes upon superovulation

• however, there is no difference in the number of oocytes superovulated in the remaining 2 mice

reproductive system

absent oocytes ( J:125354 )

• 2 of 4 females produce no oocytes upon superovulation

• however, there is no difference in the number of oocytes superovulated in the remaining 2 mice

increased corpora lutea number ( J:125354 )

• at 6 weeks, 8 to 11 weeks, and 3 months of age, the number of corpus luteums is increased compared to Inhba^tm1Zuk/Inhba^tm3Zuk mice

• the expression of a marker (Lhcgr) for healthy corpus luteums is increased relative to Inhba^tm1Zuk/Inhba^tm3Zuk mice

abnormal ovarian follicle morphology ( J:125354 )

• between 8 and 11 weeks, the number of antral follicles is decreased compared to Inhba^tm1Zuk/Inhba^tm3Zuk mice

• at 8 months, follicles with lutenizing granulosa cells and multiple fluid-filled or hemorrhagic cysts are present

abnormal tertiary ovarian follicle morphology ( J:125354 )

• between 8 and 11 weeks, the number of antral follicles is decreased compared to Inhba^tm1Zuk/Inhba^tm3Zuk mice

ovarian follicular cyst ( J:125354 )

• at 8 months, multiple fluid-filled or hemorrhagic cysts are present that are positive for a granulose cell marker but not an epithelial marker

increased ovary weight ( J:125354 )

• by 8 months, the mass of the ovaries has increased 6-fold (31.5+/-2.9 mg compared to 5.2+/-2.9 mg in Inhba^tm1Zuk/Inhba^tm3Zuk mice)

female infertility ( J:125354 )

• females are infertile

growth/size/body

ovarian follicular cyst ( J:125354 )

• at 8 months, multiple fluid-filled or hemorrhagic cysts are present that are positive for a granulose cell marker but not an epithelial marker

increased ovary weight ( J:125354 )

• by 8 months, the mass of the ovaries has increased 6-fold (31.5+/-2.9 mg compared to 5.2+/-2.9 mg in Inhba^tm1Zuk/Inhba^tm3Zuk mice)

homeostasis/metabolism

increased follicle stimulating hormone level ( J:125354 )

endocrine/exocrine glands

increased corpora lutea number ( J:125354 )

• at 6 weeks, 8 to 11 weeks, and 3 months of age, the number of corpus luteums is increased compared to Inhba^tm1Zuk/Inhba^tm3Zuk mice

• the expression of a marker (Lhcgr) for healthy corpus luteums is increased relative to Inhba^tm1Zuk/Inhba^tm3Zuk mice

abnormal ovarian follicle morphology ( J:125354 )

• between 8 and 11 weeks, the number of antral follicles is decreased compared to Inhba^tm1Zuk/Inhba^tm3Zuk mice

• at 8 months, follicles with lutenizing granulosa cells and multiple fluid-filled or hemorrhagic cysts are present

abnormal tertiary ovarian follicle morphology ( J:125354 )

• between 8 and 11 weeks, the number of antral follicles is decreased compared to Inhba^tm1Zuk/Inhba^tm3Zuk mice

ovarian follicular cyst ( J:125354 )

• at 8 months, multiple fluid-filled or hemorrhagic cysts are present that are positive for a granulose cell marker but not an epithelial marker

increased ovary weight ( J:125354 )

• by 8 months, the mass of the ovaries has increased 6-fold (31.5+/-2.9 mg compared to 5.2+/-2.9 mg in Inhba^tm1Zuk/Inhba^tm3Zuk mice)

Allelic Composition	Amhr2^tm3(cre)Bhr/Amhr2⁺ Inhba^tm1Zuk/Inhba^tm3Zuk
Genetic Background	involves: 129S7/SvEvBrd * C57BL/6J

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

reproductive system

increased corpora lutea number ( J:125354 )

• at 8 months of age, the number of corpus luteums is increased compared to in Inhba^tm1Zuk/Inhba^tm3Zuk mice

• the expression of a marker (Lhcgr) for healthy corpus luteums is increased relative to in Inhba^tm1Zuk/Inhba^tm3Zuk mice

polyovular ovarian follicle ( J:125354 )

• one follicle containing two oocytes at 3 months of age

reduced female fertility ( J:125354 )

• the number of litters produced by females is reduced 43% (0.51+/-0.05 litters per month compared 0.89+/-0.04 litters per month in Inhba^tm1Zuk/Inhba^tm3Zuk mice)

• however, there is no difference in the number of oocytes produced upon superovulation compared to Inhba^tm1Zuk/Inhba^tm3Zuk mice

decreased litter size ( J:125354 )

• the number of pups per litter is decreased 33% relative (5.19+/-0.65 pups per litter compared to 7.78+/-0.48 pups per litter in wild-type mice)

endocrine/exocrine glands

increased corpora lutea number ( J:125354 )

• at 8 months of age, the number of corpus luteums is increased compared to in Inhba^tm1Zuk/Inhba^tm3Zuk mice

• the expression of a marker (Lhcgr) for healthy corpus luteums is increased relative to in Inhba^tm1Zuk/Inhba^tm3Zuk mice

polyovular ovarian follicle ( J:125354 )

• one follicle containing two oocytes at 3 months of age

Allelic Composition	Inhba^tm1Zuk/Inhba^tm3Zuk Tg(EIIa-cre)C5379Lmgd/?
Genetic Background	involves: 129S7/SvEvBrd * C57BL/6J * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Inhba^tm1Zuk mutation (2 available); any Inhba mutation (31 available)
Inhba^tm3Zuk mutation (1 available); any Inhba mutation (31 available)
Tg(EIIa-cre)C5379Lmgd mutation (4 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

neonatal lethality, complete penetrance ( J:125354 )

• mice die shortly after birth similar to Inhba^tm1Zuk homozygotes

Allelic Composition	Inhba^tm1Zuk/Inhba⁺ Inhbb^tm1Jae/Inhbb^tm1Jae
Genetic Background	involves: 129S4/SvJae * 129S7/SvEvBrd

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Inhba^tm1Zuk mutation (2 available); any Inhba mutation (31 available)
Inhbb^tm1Jae mutation (3 available); any Inhbb mutation (24 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

reproductive system

increased corpora lutea number ( J:125354 )

• beginning at 3 months of age and readily identifiable by 8 months of age, the number of corpus luteums is increased relative to Inhba^tm1Zuk/Inhba^tm3Zuk mice

• the expression of a marker (Lhcgr) for healthy corpus luteums is increased relative to Inhba^tm1Zuk/Inhba^tm3Zuk mice

female infertility ( J:125354 )

• 3 of 11 females are infertile

reduced female fertility ( J:125354 )

• the number of litters produced by females is reduced 43% (0.08+/-0.08 litters per month compared 0.89+/-0.04 litters per month in Inhba^tm1Zuk/Inhba^tm3Zuk mice)

• however, there is no difference in the number of oocytes produced upon superovulation compared to Inhba^tm1Zuk/Inhba^tm3Zuk females

decreased litter size ( J:125354 )

• the number of pups per litter is decreased 33% relative (.80+/-0.49 pups per litter compared to 7.78+/-0.48 pups per litter in Inhba^tm1Zuk/Inhba^tm3Zuk mice)

endocrine/exocrine glands

increased corpora lutea number ( J:125354 )

• beginning at 3 months of age and readily identifiable by 8 months of age, the number of corpus luteums is increased relative to Inhba^tm1Zuk/Inhba^tm3Zuk mice

• the expression of a marker (Lhcgr) for healthy corpus luteums is increased relative to Inhba^tm1Zuk/Inhba^tm3Zuk mice

Allelic Composition	Inhba^tm1Zuk/Inhba^tm1Zuk Inhbb^tm1Jae/Inhbb^tm1Jae
Genetic Background	involves: 129S4/SvJae * 129S7/SvEvBrd * C57BL/6

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

neonatal lethality, incomplete penetrance ( J:23923 )

• 3 of 9 mice (33%) die from cleft secondary palates

craniofacial

absent incisors ( J:23923 )

cleft secondary palate ( J:23923 )

• 3 of 9 mice (33%) die from cleft secondary palates

vision/eye

eyelids open at birth ( J:23923 )

digestive/alimentary system

cleft secondary palate ( J:23923 )

• 3 of 9 mice (33%) die from cleft secondary palates

integument

absent vibrissae ( J:23923 )

growth/size/body

absent incisors ( J:23923 )

cleft secondary palate ( J:23923 )

• 3 of 9 mice (33%) die from cleft secondary palates

skeleton

absent incisors ( J:23923 )

Allelic Composition	Inhba^tm1Zuk/Inhba^tm3Zuk Inhbb^tm1Jae/Inhbb^tm1Jae
Genetic Background	involves: 129S4/SvJae * 129S7/SvEvBrd * C57BL/6J

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

reproductive system

female infertility ( J:125354 )

• 3 of 5 females are infertile

reduced female fertility ( J:125354 )

• the number of litters produced by females is reduced 43% (0.10+/-0.07 litters per month compared 0.89+/-0.04 litters per month in Inhba^tm1Zuk/Inhba^tm3Zuk mice)

• however, there is no difference in the number of oocytes produced upon superovulation compared to Inhba^tm1Zuk/Inhba^tm3Zuk females

decreased litter size ( J:125354 )

• the number of pups per litter is decreased 33% relative (1.00+/-0.63 pups per litter compared to 7.78+/-0.48 pups per litter in Inhba^tm1Zuk/Inhba^tm3Zuk mice)

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