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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Lyntm1Sor
targeted mutation 1, Philippe Soriano
MGI:1861966
Summary 8 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Lyntm1Sor/Lyntm1Sor B6.129S4-Lyntm1Sor MGI:3785294
hm2
Lyntm1Sor/Lyntm1Sor involves: 129S4/SvJae MGI:2182295
hm3
Lyntm1Sor/Lyntm1Sor involves: 129S4/SvJaeSor MGI:3815320
hm4
Lyntm1Sor/Lyntm1Sor involves: 129S4/SvJaeSor * C57BL/6 MGI:5000443
cx5
Fgrtm1Hev/Fgrtm1Hev
Hcktm1Hev/Hcktm1Hev
Lyntm1Sor/Lyntm1Sor
B6.Cg-Hcktm1Hev Fgrtm1Hev Lyntm1Sor MGI:3785296
cx6
Ightm2Mnz/Ightm2Mnz
Lyntm1Sor/Lyntm1Sor
involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6 MGI:3712646
cx7
Ightm1Mnz/Ightm1Mnz
Lyntm1Sor/Lyntm1Sor
involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6 MGI:3712645
cx8
Cd19tm1Tft/Cd19tm1Tft
Lyntm1Sor/Lyntm1Sor
involves: 129S4/SvJaeSor * C57BL/6 MGI:5000444


Genotype
MGI:3785294
hm1
Allelic
Composition
Lyntm1Sor/Lyntm1Sor
Genetic
Background
B6.129S4-Lyntm1Sor
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lyntm1Sor mutation (2 available); any Lyn mutation (65 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• following exposure to LPS then challenge with TNF at the same site to initiate a local Shwartman response, mice exhibit a modest reduction in hemorrhages compared to the thrombohemorrhagic vasculitis observed in wild-type mice




Genotype
MGI:2182295
hm2
Allelic
Composition
Lyntm1Sor/Lyntm1Sor
Genetic
Background
involves: 129S4/SvJae
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lyntm1Sor mutation (2 available); any Lyn mutation (65 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• B cell proliferation is more sensitive to anti-IgM than wild-type B cells
• at 14 weeks of age
• mice exhibit a decrease in conventional B cells due to increased higher turnover rates than in wild-type mice
• peripheral B cell numbers are reduced by 50% to 70% of wild-type
• B220loHSAhi B lymphocytes are decreased 2- to 5-fold in lymphoid compartments
• at 14 weeks of age, splenomegaly is often accompanied by enlargments of the lymph nodes with lymphoblasts and plasma cells
• blast cells within the lymph node are activated and have a B1 identity
• mice develop anti-dsDNA antibodies around 16 weeks of age unlike wild-type mice

hematopoietic system
• B cell proliferation is more sensitive to anti-IgM than wild-type B cells
• at 14 weeks of age
• mice exhibit a decrease in conventional B cells due to increased higher turnover rates than in wild-type mice
• peripheral B cell numbers are reduced by 50% to 70% of wild-type
• B220loHSAhi B lymphocytes are decreased 2- to 5-fold in lymphoid compartments

growth/size/body
• at 14 weeks of age

cellular
• B cell proliferation is more sensitive to anti-IgM than wild-type B cells




Genotype
MGI:3815320
hm3
Allelic
Composition
Lyntm1Sor/Lyntm1Sor
Genetic
Background
involves: 129S4/SvJaeSor
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lyntm1Sor mutation (2 available); any Lyn mutation (65 available)
phenotype observed in females
phenotype observed in males
N normal phenotype

Lupus-like autoimmune disease in Lyntm1Sor/Lyntm1Sor and Lyntm1.1Calo/Lyntm1.1Calo Top2aGt(PST14568)Mfgc/0 mice

immune system
• B cells form mice 7- to 11- weeks of age hyperproliferate in response to anti-IgM stimulation and LPS
• mice develop splenomegaly with age due to myeloid hyperplasia
• increase in the number of CD19lo/- CD138hi plasma cells in the spleen
• reduced numbers of T1 and T2 B cells are found in the spleen
• peripheral B cell numbers are reduced by almost 10-fold
• reduced by about 10-fold in the spleen
• reduced numbers in the spleen
• mice have elevated levels of IgA in sera
• mice have elevated levels of IgM in sera
• fibrillar beta-amyloid stimulated reactive oxygen species production is reduced 70% compared to in wild-type cells
• however, response to zymosan and macrophage recruitment are normal
• fibrillar beta-amyloid stimulated microglial recruitment is reduced 3-fold compared to in wild-type mice
• increased levels of granulocyte and granulocyte macrophage colony stimulating factors at 6 months of age
• high levels of circulating B-cell activating factor
• increased levels of a number of chemokines at 6 months of age
• fibrillar beta-amyloid stimulated MCP-1 production in macrophages is reduced by 50% compared to in wild-type mice
• however, macrophage production of MCP-1 in response to LPS or reverse beta-amyloid is normal
• splenic dendritic cells produce more proinflammatory cytokines and more chemokines
• CD11chi DCs are hyperresponsive to cytokine stimulation
• high levels of autoreactive antibodies in the serum
• serum levels of anti-dsDNA antibodies increase with age with high levels occurring by 12 months of age
• levels of anti-dsDNA antibodies are below those of age-matched Lyn null homozygotes
• IgG depositions in the liver occur in older mice though no associated pathology is observed
• mice develop severe glomerulonephritis around 8 months of age (J:146161)
• disease includes enlarged glomeruli, glomerular, hypercellularity, lobularity and sclerosis, mesangial interposition in peripheral capillary loops, and strong IgG deposition in the glomeruli (J:146161)
• glomerulonephritis without interstitial inflammation is seen by 8-10 months of age (J:200745)

nervous system
• fibrillar beta-amyloid stimulated microglial recruitment is reduced 3-fold compared to in wild-type mice

renal/urinary system
• mesangial interposition in peripheral capillary loops
• mice develop severe glomerulonephritis around 8 months of age (J:146161)
• disease includes enlarged glomeruli, glomerular, hypercellularity, lobularity and sclerosis, mesangial interposition in peripheral capillary loops, and strong IgG deposition in the glomeruli (J:146161)
• glomerulonephritis without interstitial inflammation is seen by 8-10 months of age (J:200745)
• deposition of C3 in the glomeruli
• enlarged glomeruli

liver/biliary system
• IgG depositions in the liver occur in older mice though no associated pathology is observed

hematopoietic system
• B cells form mice 7- to 11- weeks of age hyperproliferate in response to anti-IgM stimulation and LPS
• mice develop splenomegaly with age due to myeloid hyperplasia
• mice exhibit an accumulation of erythroid progenitor cells in the Kit+CD71high compartment compared to in wild-type mice
• the ratio of Kit+ to Kit- proerythroblasts is increased compared to in wild-type mice
• increase in the number of CD19lo/- CD138hi plasma cells in the spleen
• reduced numbers of T1 and T2 B cells are found in the spleen
• peripheral B cell numbers are reduced by almost 10-fold
• reduced by about 10-fold in the spleen
• reduced numbers in the spleen
• mice have elevated levels of IgA in sera
• mice have elevated levels of IgM in sera
• fibrillar beta-amyloid stimulated reactive oxygen species production is reduced 70% compared to in wild-type cells
• however, response to zymosan and macrophage recruitment are normal
• fibrillar beta-amyloid stimulated microglial recruitment is reduced 3-fold compared to in wild-type mice

homeostasis/metabolism
• increased levels of granulocyte and granulocyte macrophage colony stimulating factors at 6 months of age
• high levels of circulating B-cell activating factor
• increased levels of a number of chemokines at 6 months of age
• fibrillar beta-amyloid stimulated MCP-1 production in macrophages is reduced by 50% compared to in wild-type mice
• however, macrophage production of MCP-1 in response to LPS or reverse beta-amyloid is normal

cellular
• mesangial interposition in peripheral capillary loops
• B cells form mice 7- to 11- weeks of age hyperproliferate in response to anti-IgM stimulation and LPS

growth/size/body
• mice develop splenomegaly with age due to myeloid hyperplasia




Genotype
MGI:5000443
hm4
Allelic
Composition
Lyntm1Sor/Lyntm1Sor
Genetic
Background
involves: 129S4/SvJaeSor * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lyntm1Sor mutation (2 available); any Lyn mutation (65 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• in response to BCR ligation
• however, B cell proliferation in response to LPS stimulation is normal
• bone marrow exhibit a modest decrease in IgM-B220low pro/pre B cells or IgM+ B220low immature B cells compared with wild-type mice
• circulating, splenic, peritoneal, and lymph node B cells are decreased compared to in wild-type mice
• in the serum and kidney deposits

renal/urinary system

hematopoietic system
• in response to BCR ligation
• however, B cell proliferation in response to LPS stimulation is normal
• bone marrow exhibit a modest decrease in IgM-B220low pro/pre B cells or IgM+ B220low immature B cells compared with wild-type mice
• circulating, splenic, peritoneal, and lymph node B cells are decreased compared to in wild-type mice
• in the serum and kidney deposits

cellular
• in response to BCR ligation
• however, B cell proliferation in response to LPS stimulation is normal

growth/size/body




Genotype
MGI:3785296
cx5
Allelic
Composition
Fgrtm1Hev/Fgrtm1Hev
Hcktm1Hev/Hcktm1Hev
Lyntm1Sor/Lyntm1Sor
Genetic
Background
B6.Cg-Hcktm1Hev Fgrtm1Hev Lyntm1Sor
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fgrtm1Hev mutation (0 available); any Fgr mutation (132 available)
Hcktm1Hev mutation (0 available); any Hck mutation (31 available)
Lyntm1Sor mutation (2 available); any Lyn mutation (65 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• neutrophil degranulation after adhesion is decreased compared to in wild-type mice
• following exposure to LPS then challenge with TNF at the same site to initiate a local Shwartman response, mice exhibit no hemorrhages and reduced fibrin deposition compared to the thrombohemorrhagic vasculitis observed in wild-type mice
• however, neutrophil migration is normal

hematopoietic system
• neutrophil degranulation after adhesion is decreased compared to in wild-type mice




Genotype
MGI:3712646
cx6
Allelic
Composition
Ightm2Mnz/Ightm2Mnz
Lyntm1Sor/Lyntm1Sor
Genetic
Background
involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ightm2Mnz mutation (1 available); any Igh mutation (44 available)
Lyntm1Sor mutation (2 available); any Lyn mutation (65 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• number of B cells differentiating into germinal center B cells and plasmacytes is diminished compared to Ightm2Mnz mice
• antigen specific B cell proliferation is similar to wild-type CD19 Ightm2Mnz mice
• expansion is prolonged with increased levels of Ig lambda+ cells remaining 12 days after immunization

hematopoietic system
• number of B cells differentiating into germinal center B cells and plasmacytes is diminished compared to Ightm2Mnz mice
• antigen specific B cell proliferation is similar to wild-type CD19 Ightm2Mnz mice
• expansion is prolonged with increased levels of Ig lambda+ cells remaining 12 days after immunization

cellular
• antigen specific B cell proliferation is similar to wild-type CD19 Ightm2Mnz mice
• expansion is prolonged with increased levels of Ig lambda+ cells remaining 12 days after immunization




Genotype
MGI:3712645
cx7
Allelic
Composition
Ightm1Mnz/Ightm1Mnz
Lyntm1Sor/Lyntm1Sor
Genetic
Background
involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ightm1Mnz mutation (4 available); any Igh mutation (44 available)
Lyntm1Sor mutation (2 available); any Lyn mutation (65 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• number of B cells differentiating into germinal center B cells and plasmacytes is diminished compared to Ightm1Mnz mice
• antigen-specific B cell proliferation is enhanced compared to Ightm1Mnz mice that are CD19-wild-type (56.8% of B cells are Ig lambda+ vs 40%)
• expansion is prolonged with increased levels of Ig lambda+ cells remaining 12 days after immunization

hematopoietic system
• number of B cells differentiating into germinal center B cells and plasmacytes is diminished compared to Ightm1Mnz mice
• antigen-specific B cell proliferation is enhanced compared to Ightm1Mnz mice that are CD19-wild-type (56.8% of B cells are Ig lambda+ vs 40%)
• expansion is prolonged with increased levels of Ig lambda+ cells remaining 12 days after immunization

cellular
• antigen-specific B cell proliferation is enhanced compared to Ightm1Mnz mice that are CD19-wild-type (56.8% of B cells are Ig lambda+ vs 40%)
• expansion is prolonged with increased levels of Ig lambda+ cells remaining 12 days after immunization




Genotype
MGI:5000444
cx8
Allelic
Composition
Cd19tm1Tft/Cd19tm1Tft
Lyntm1Sor/Lyntm1Sor
Genetic
Background
involves: 129S4/SvJaeSor * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd19tm1Tft mutation (0 available); any Cd19 mutation (60 available)
Lyntm1Sor mutation (2 available); any Lyn mutation (65 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
N
• IgA, IgM, and IgG levels are the same as in wild-type mice
• in response to BCR ligation or LPS stimulation
• but not as much as in Lyntm1Sor homozygotes
• bone marrow exhibit a modest decrease in IgM-B220low pro/pre B cells or IgM+ B220low immature B cells compared with wild-type mice
• circulating, splenic, peritoneal, and lymph node B cells are decreased compared to in wild-type mice
• bone marrow exhibit a decrease in IgM+ B220high compared with wild-type mice
• after immunization, anti-DNP IgM antibody production is delayed compared with wild-type mice
• IgG1 response is delayed and modest compared to in wild-type mice
• compared with Lyntm1Sor homozygotes
• compared with Lyntm1Sor homozygotes

hematopoietic system
• in response to BCR ligation or LPS stimulation
• but not as much as in Lyntm1Sor homozygotes
• bone marrow exhibit a modest decrease in IgM-B220low pro/pre B cells or IgM+ B220low immature B cells compared with wild-type mice
• circulating, splenic, peritoneal, and lymph node B cells are decreased compared to in wild-type mice
• bone marrow exhibit a decrease in IgM+ B220high compared with wild-type mice

cellular
• in response to BCR ligation or LPS stimulation

growth/size/body
• but not as much as in Lyntm1Sor homozygotes





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last database update
11/12/2024
MGI 6.24
The Jackson Laboratory