About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Lyntm1Sor
targeted mutation 1, Philippe Soriano
MGI:1861966
Summary 8 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Lyntm1Sor/Lyntm1Sor B6.129S4-Lyntm1Sor MGI:3785294
hm2
Lyntm1Sor/Lyntm1Sor involves: 129S4/SvJae MGI:2182295
hm3
Lyntm1Sor/Lyntm1Sor involves: 129S4/SvJaeSor MGI:3815320
hm4
Lyntm1Sor/Lyntm1Sor involves: 129S4/SvJaeSor * C57BL/6 MGI:5000443
cx5
Fgrtm1Hev/Fgrtm1Hev
Hcktm1Hev/Hcktm1Hev
Lyntm1Sor/Lyntm1Sor
B6.Cg-Hcktm1Hev Fgrtm1Hev Lyntm1Sor MGI:3785296
cx6
Ightm2Mnz/Ightm2Mnz
Lyntm1Sor/Lyntm1Sor
involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6 MGI:3712646
cx7
Ightm1Mnz/Ightm1Mnz
Lyntm1Sor/Lyntm1Sor
involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6 MGI:3712645
cx8
Cd19tm1Tft/Cd19tm1Tft
Lyntm1Sor/Lyntm1Sor
involves: 129S4/SvJaeSor * C57BL/6 MGI:5000444


Genotype
MGI:3785294
hm1
Allelic
Composition
Lyntm1Sor/Lyntm1Sor
Genetic
Background
B6.129S4-Lyntm1Sor
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lyntm1Sor mutation (2 available); any Lyn mutation (65 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• following exposure to LPS then challenge with TNF at the same site to initiate a local Shwartman response, mice exhibit a modest reduction in hemorrhages compared to the thrombohemorrhagic vasculitis observed in wild-type mice




Genotype
MGI:2182295
hm2
Allelic
Composition
Lyntm1Sor/Lyntm1Sor
Genetic
Background
involves: 129S4/SvJae
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lyntm1Sor mutation (2 available); any Lyn mutation (65 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• B cell proliferation is more sensitive to anti-IgM than wild-type B cells
• at 14 weeks of age
• mice exhibit a decrease in conventional B cells due to increased higher turnover rates than in wild-type mice
• peripheral B cell numbers are reduced by 50% to 70% of wild-type
• B220loHSAhi B lymphocytes are decreased 2- to 5-fold in lymphoid compartments
• at 14 weeks of age, splenomegaly is often accompanied by enlargments of the lymph nodes with lymphoblasts and plasma cells
• blast cells within the lymph node are activated and have a B1 identity
• mice develop anti-dsDNA antibodies around 16 weeks of age unlike wild-type mice

hematopoietic system
• B cell proliferation is more sensitive to anti-IgM than wild-type B cells
• at 14 weeks of age
• mice exhibit a decrease in conventional B cells due to increased higher turnover rates than in wild-type mice
• peripheral B cell numbers are reduced by 50% to 70% of wild-type
• B220loHSAhi B lymphocytes are decreased 2- to 5-fold in lymphoid compartments

growth/size/body
• at 14 weeks of age

cellular
• B cell proliferation is more sensitive to anti-IgM than wild-type B cells




Genotype
MGI:3815320
hm3
Allelic
Composition
Lyntm1Sor/Lyntm1Sor
Genetic
Background
involves: 129S4/SvJaeSor
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lyntm1Sor mutation (2 available); any Lyn mutation (65 available)
phenotype observed in females
phenotype observed in males
N normal phenotype

Lupus-like autoimmune disease in Lyntm1Sor/Lyntm1Sor and Lyntm1.1Calo/Lyntm1.1Calo Top2aGt(PST14568)Mfgc/0 mice

immune system
• B cells form mice 7- to 11- weeks of age hyperproliferate in response to anti-IgM stimulation and LPS
• mice develop splenomegaly with age due to myeloid hyperplasia
• increase in the number of CD19lo/- CD138hi plasma cells in the spleen
• reduced numbers of T1 and T2 B cells are found in the spleen
• peripheral B cell numbers are reduced by almost 10-fold
• reduced by about 10-fold in the spleen
• reduced numbers in the spleen
• mice have elevated levels of IgA in sera
• mice have elevated levels of IgM in sera
• fibrillar beta-amyloid stimulated reactive oxygen species production is reduced 70% compared to in wild-type cells
• however, response to zymosan and macrophage recruitment are normal
• fibrillar beta-amyloid stimulated microglial recruitment is reduced 3-fold compared to in wild-type mice
• increased levels of granulocyte and granulocyte macrophage colony stimulating factors at 6 months of age
• high levels of circulating B-cell activating factor
• increased levels of a number of chemokines at 6 months of age
• fibrillar beta-amyloid stimulated MCP-1 production in macrophages is reduced by 50% compared to in wild-type mice
• however, macrophage production of MCP-1 in response to LPS or reverse beta-amyloid is normal
• splenic dendritic cells produce more proinflammatory cytokines and more chemokines
• CD11chi DCs are hyperresponsive to cytokine stimulation
• high levels of autoreactive antibodies in the serum
• serum levels of anti-dsDNA antibodies increase with age with high levels occurring by 12 months of age
• levels of anti-dsDNA antibodies are below those of age-matched Lyn null homozygotes
• IgG depositions in the liver occur in older mice though no associated pathology is observed
• mice develop severe glomerulonephritis around 8 months of age (J:146161)
• disease includes enlarged glomeruli, glomerular, hypercellularity, lobularity and sclerosis, mesangial interposition in peripheral capillary loops, and strong IgG deposition in the glomeruli (J:146161)
• glomerulonephritis without interstitial inflammation is seen by 8-10 months of age (J:200745)

nervous system
• fibrillar beta-amyloid stimulated microglial recruitment is reduced 3-fold compared to in wild-type mice

renal/urinary system
• mesangial interposition in peripheral capillary loops
• mice develop severe glomerulonephritis around 8 months of age (J:146161)
• disease includes enlarged glomeruli, glomerular, hypercellularity, lobularity and sclerosis, mesangial interposition in peripheral capillary loops, and strong IgG deposition in the glomeruli (J:146161)
• glomerulonephritis without interstitial inflammation is seen by 8-10 months of age (J:200745)
• deposition of C3 in the glomeruli
• enlarged glomeruli

liver/biliary system
• IgG depositions in the liver occur in older mice though no associated pathology is observed

hematopoietic system
• B cells form mice 7- to 11- weeks of age hyperproliferate in response to anti-IgM stimulation and LPS
• mice develop splenomegaly with age due to myeloid hyperplasia
• mice exhibit an accumulation of erythroid progenitor cells in the Kit+CD71high compartment compared to in wild-type mice
• the ratio of Kit+ to Kit- proerythroblasts is increased compared to in wild-type mice
• increase in the number of CD19lo/- CD138hi plasma cells in the spleen
• reduced numbers of T1 and T2 B cells are found in the spleen
• peripheral B cell numbers are reduced by almost 10-fold
• reduced by about 10-fold in the spleen
• reduced numbers in the spleen
• mice have elevated levels of IgA in sera
• mice have elevated levels of IgM in sera
• fibrillar beta-amyloid stimulated reactive oxygen species production is reduced 70% compared to in wild-type cells
• however, response to zymosan and macrophage recruitment are normal
• fibrillar beta-amyloid stimulated microglial recruitment is reduced 3-fold compared to in wild-type mice

homeostasis/metabolism
• increased levels of granulocyte and granulocyte macrophage colony stimulating factors at 6 months of age
• high levels of circulating B-cell activating factor
• increased levels of a number of chemokines at 6 months of age
• fibrillar beta-amyloid stimulated MCP-1 production in macrophages is reduced by 50% compared to in wild-type mice
• however, macrophage production of MCP-1 in response to LPS or reverse beta-amyloid is normal

cellular
• mesangial interposition in peripheral capillary loops
• B cells form mice 7- to 11- weeks of age hyperproliferate in response to anti-IgM stimulation and LPS

growth/size/body
• mice develop splenomegaly with age due to myeloid hyperplasia




Genotype
MGI:5000443
hm4
Allelic
Composition
Lyntm1Sor/Lyntm1Sor
Genetic
Background
involves: 129S4/SvJaeSor * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lyntm1Sor mutation (2 available); any Lyn mutation (65 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• in response to BCR ligation
• however, B cell proliferation in response to LPS stimulation is normal
• bone marrow exhibit a modest decrease in IgM-B220low pro/pre B cells or IgM+ B220low immature B cells compared with wild-type mice
• circulating, splenic, peritoneal, and lymph node B cells are decreased compared to in wild-type mice
• in the serum and kidney deposits

renal/urinary system

hematopoietic system
• in response to BCR ligation
• however, B cell proliferation in response to LPS stimulation is normal
• bone marrow exhibit a modest decrease in IgM-B220low pro/pre B cells or IgM+ B220low immature B cells compared with wild-type mice
• circulating, splenic, peritoneal, and lymph node B cells are decreased compared to in wild-type mice
• in the serum and kidney deposits

cellular
• in response to BCR ligation
• however, B cell proliferation in response to LPS stimulation is normal

growth/size/body




Genotype
MGI:3785296
cx5
Allelic
Composition
Fgrtm1Hev/Fgrtm1Hev
Hcktm1Hev/Hcktm1Hev
Lyntm1Sor/Lyntm1Sor
Genetic
Background
B6.Cg-Hcktm1Hev Fgrtm1Hev Lyntm1Sor
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fgrtm1Hev mutation (0 available); any Fgr mutation (132 available)
Hcktm1Hev mutation (0 available); any Hck mutation (31 available)
Lyntm1Sor mutation (2 available); any Lyn mutation (65 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• neutrophil degranulation after adhesion is decreased compared to in wild-type mice
• following exposure to LPS then challenge with TNF at the same site to initiate a local Shwartman response, mice exhibit no hemorrhages and reduced fibrin deposition compared to the thrombohemorrhagic vasculitis observed in wild-type mice
• however, neutrophil migration is normal

hematopoietic system
• neutrophil degranulation after adhesion is decreased compared to in wild-type mice




Genotype
MGI:3712646
cx6
Allelic
Composition
Ightm2Mnz/Ightm2Mnz
Lyntm1Sor/Lyntm1Sor
Genetic
Background
involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ightm2Mnz mutation (1 available); any Igh mutation (44 available)
Lyntm1Sor mutation (2 available); any Lyn mutation (65 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• number of B cells differentiating into germinal center B cells and plasmacytes is diminished compared to Ightm2Mnz mice
• antigen specific B cell proliferation is similar to wild-type CD19 Ightm2Mnz mice
• expansion is prolonged with increased levels of Ig lambda+ cells remaining 12 days after immunization

hematopoietic system
• number of B cells differentiating into germinal center B cells and plasmacytes is diminished compared to Ightm2Mnz mice
• antigen specific B cell proliferation is similar to wild-type CD19 Ightm2Mnz mice
• expansion is prolonged with increased levels of Ig lambda+ cells remaining 12 days after immunization

cellular
• antigen specific B cell proliferation is similar to wild-type CD19 Ightm2Mnz mice
• expansion is prolonged with increased levels of Ig lambda+ cells remaining 12 days after immunization




Genotype
MGI:3712645
cx7
Allelic
Composition
Ightm1Mnz/Ightm1Mnz
Lyntm1Sor/Lyntm1Sor
Genetic
Background
involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ightm1Mnz mutation (4 available); any Igh mutation (44 available)
Lyntm1Sor mutation (2 available); any Lyn mutation (65 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• number of B cells differentiating into germinal center B cells and plasmacytes is diminished compared to Ightm1Mnz mice
• antigen-specific B cell proliferation is enhanced compared to Ightm1Mnz mice that are CD19-wild-type (56.8% of B cells are Ig lambda+ vs 40%)
• expansion is prolonged with increased levels of Ig lambda+ cells remaining 12 days after immunization

hematopoietic system
• number of B cells differentiating into germinal center B cells and plasmacytes is diminished compared to Ightm1Mnz mice
• antigen-specific B cell proliferation is enhanced compared to Ightm1Mnz mice that are CD19-wild-type (56.8% of B cells are Ig lambda+ vs 40%)
• expansion is prolonged with increased levels of Ig lambda+ cells remaining 12 days after immunization

cellular
• antigen-specific B cell proliferation is enhanced compared to Ightm1Mnz mice that are CD19-wild-type (56.8% of B cells are Ig lambda+ vs 40%)
• expansion is prolonged with increased levels of Ig lambda+ cells remaining 12 days after immunization




Genotype
MGI:5000444
cx8
Allelic
Composition
Cd19tm1Tft/Cd19tm1Tft
Lyntm1Sor/Lyntm1Sor
Genetic
Background
involves: 129S4/SvJaeSor * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd19tm1Tft mutation (0 available); any Cd19 mutation (60 available)
Lyntm1Sor mutation (2 available); any Lyn mutation (65 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
N
• IgA, IgM, and IgG levels are the same as in wild-type mice
• in response to BCR ligation or LPS stimulation
• but not as much as in Lyntm1Sor homozygotes
• bone marrow exhibit a modest decrease in IgM-B220low pro/pre B cells or IgM+ B220low immature B cells compared with wild-type mice
• circulating, splenic, peritoneal, and lymph node B cells are decreased compared to in wild-type mice
• bone marrow exhibit a decrease in IgM+ B220high compared with wild-type mice
• after immunization, anti-DNP IgM antibody production is delayed compared with wild-type mice
• IgG1 response is delayed and modest compared to in wild-type mice
• compared with Lyntm1Sor homozygotes
• compared with Lyntm1Sor homozygotes

hematopoietic system
• in response to BCR ligation or LPS stimulation
• but not as much as in Lyntm1Sor homozygotes
• bone marrow exhibit a modest decrease in IgM-B220low pro/pre B cells or IgM+ B220low immature B cells compared with wild-type mice
• circulating, splenic, peritoneal, and lymph node B cells are decreased compared to in wild-type mice
• bone marrow exhibit a decrease in IgM+ B220high compared with wild-type mice

cellular
• in response to BCR ligation or LPS stimulation

growth/size/body
• but not as much as in Lyntm1Sor homozygotes





Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support.
last database update
10/29/2024
MGI 6.24
The Jackson Laboratory