Phenotypes associated with this allele

• Allele Symbol: Map2k4^tm1Lizon
• Allele Name: targeted mutation 1, Leonard I Zon
• Allele ID: MGI:1861969
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Map2k4^tm1Lizon/Map2k4^tm1Lizon	involves: 129S1/Sv	MGI:2183038

Genotype
MGI:2183038

hm1

• Allelic Composition: Map2k4^tm1Lizon/Map2k4^tm1Lizon
• Genetic Background: involves: 129S1/Sv

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

prenatal lethality, complete penetrance ( J:48772 )

• death after E12.5

liver/biliary system

dilated liver sinusoidal space ( J:48772 )

liver hemorrhage ( J:48772 )

• hemorrhaging in the liver region was noted

increased hepatocyte apoptosis ( J:48772 )

• a ~2-fold increase in the number of apoptotic hepatocytes at E12.5

abnormal liver development ( J:48772 )

• many embryonic livers have two small lobes

abnormal liver bud morphology ( J:48772 )

• liver bud forms but is considerably reduced in size

decreased hepatocyte number ( J:48772 )

• reduced number of hepatocytes at E11.5 to E12.5

cardiovascular system

dilated liver sinusoidal space ( J:48772 )

liver hemorrhage ( J:48772 )

• hemorrhaging in the liver region was noted

cellular

increased hepatocyte apoptosis ( J:48772 )

• a ~2-fold increase in the number of apoptotic hepatocytes at E12.5

integument

pallor ( J:48772 )

• pale embryos