All Phenotypes Mar1<tm1Wtg> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Mar1^tm1Wtg
targeted mutation 1, William T Garrard
MGI:1861975

Summary

2 genotypes

Allelic Composition	Mar1^tm1Wtg/Mar1^tm1Wtg
Genetic Background	involves: 129S6/SvEvTac * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mar1^tm1Wtg mutation (1 available); any Mar1 mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

• somatic hypermutations are increased on the Mar1^tm1Wtg allele

hematopoietic system

• somatic hypermutations are increased on the Mar1^tm1Wtg allele

Allelic Composition	Mar1^tm1Wtg/Mar1⁺
Genetic Background	involves: 129S6/SvEvTac * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mar1^tm1Wtg mutation (1 available); any Mar1 mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

abnormal immune system physiology ( J:68024 )

• in pro-B cells Ikappa VDJ rearrangement is enhanced

• somatic hypermutations are increased on the Mar1^tm1Wtg allele

hematopoietic system

• somatic hypermutations are increased on the Mar1^tm1Wtg allele

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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