All Phenotypes Mdm4<Gt(VICTR20)7Lex> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Mdm4^{Gt(VICTR20)7Lex}
gene trap 7, Lexicon Genetics
MGI:1861977

Summary

11 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Mdm4^{Gt(VICTR20)7Lex}/Mdm4^{Gt(VICTR20)7Lex}	involves: 129S5/SvEvBrd	MGI:3700234
hm2	Mdm4^{Gt(VICTR20)7Lex}/Mdm4^{Gt(VICTR20)7Lex}	involves: 129S5/SvEvBrd * 129S6/SvEvTac * C57BL/6 * FVB/N	MGI:4840454
cx3	Mdm2^tm1Glo/Mdm2⁺ Mdm4^{Gt(VICTR20)7Lex}/Mdm4⁺ Trp53^tm3Wahl/Trp53^tm3Wahl	involves: 129	MGI:3700144
cx4	Mdm4^{Gt(VICTR20)7Lex}/Mdm4^{Gt(VICTR20)7Lex} Trp53^tm1Tyj/Trp53⁺	involves: 129S2/SvPas * 129S5/SvEvBrd	MGI:3700236
cx5	Mdm4^{Gt(VICTR20)7Lex}/Mdm4^{Gt(VICTR20)7Lex} Trp53^tm1Tyj/Trp53^tm1Tyj	involves: 129S2/SvPas * 129S5/SvEvBrd	MGI:3700235
cx6	Mdm4^{Gt(VICTR20)7Lex}/Mdm4^{Gt(VICTR20)7Lex} Trp53^tm3Wahl/Trp53^tm3Wahl	involves: 129S4/SvJae * 129S5/SvEvBrd	MGI:3700141
cx7	Mdm4^{Gt(VICTR20)7Lex}/Mdm4^{Gt(VICTR20)7Lex} Trp53^tm1.1Xlu/Trp53^tm1.1Xlu	involves: 129S5/SvEvBrd * 129S6/SvEvTac * C57BL/6 * FVB/N	MGI:4840452
cx8	Mdm4^{Gt(VICTR20)7Lex}/Mdm4⁺ Trp53^tm1.1Xlu/Trp53^tm1.1Xlu	involves: 129S5/SvEvBrd * 129S6/SvEvTac * C57BL/6 * FVB/N	MGI:4840453
cx9	Mdm2^tm1Glo/Mdm2⁺ Mdm4^{Gt(VICTR20)7Lex}/Mdm4⁺ Trp53^tm1Wahl/Trp53^tm1Wahl	involves: 129S5/SvEvBrd * 129S7/SvEvBrd * C57BL/6	MGI:3625182
cx10	Mdm4^{Gt(VICTR20)7Lex}/Mdm4⁺ Trp53^tm1Wahl/Trp53^tm1Wahl	involves: 129S5/SvEvBrd * C57BL/6	MGI:3625181
cx11	Mdm4^{Gt(VICTR20)7Lex}/Mdm4^{Gt(VICTR20)7Lex} Trp53^tm1Wahl/Trp53^tm1Wahl	involves: 129S5/SvEvBrd * C57BL/6	MGI:3625172

Allelic Composition	Mdm4^{Gt(VICTR20)7Lex}/Mdm4^{Gt(VICTR20)7Lex}
Genetic Background	involves: 129S5/SvEvBrd

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mdm4^{Gt(VICTR20)7Lex} mutation (0 available); any Mdm4 mutation (191 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:77907 )

• die between E9.5 and E12.5

cellular

abnormal cell cycle ( J:77907 )

• accumulation of cells at the G0 - G1 phase

decreased cell proliferation ( J:77907 )

• reduced proliferation in the embryo as a whole and particularly in the liver at E12

• dramatic reduction in proliferation rate of MEFs from E10.5 embryos and proliferation potential is reduced with cell showing signs of premature senescence as early as after 2 passages in culture

embryo

decreased embryo size ( J:77907 )

• by E9.5 - E10.5, most or all mice display variable overall growth deficiency without signs of developmental arrest

abnormal neural tube closure ( J:77907 )

• at E10.5, improper neural tube closure is seen

nervous system

dilated lateral ventricle ( J:77907 )

• at E10.5, most likely the result of increased apoptosis

telencephalon hypoplasia ( J:77907 )

• apoptosis results in thinning of the telencephalic wall

abnormal nervous system development ( J:77907 )

• at E9.5 - E11.5, extensive cell death is seen specifically in the developing CNS with apoptosis predominantly occurring in the mantle zone of the hindbrain and spinal cord neuroepithelium

abnormal neural tube closure ( J:77907 )

• at E10.5, improper neural tube closure is seen

growth/size/body

decreased embryo size ( J:77907 )

• by E9.5 - E10.5, most or all mice display variable overall growth deficiency without signs of developmental arrest

integument

pallor ( J:77907 )

• strikingly paler at E11.5 compared to littermate controls

Allelic Composition	Mdm4^{Gt(VICTR20)7Lex}/Mdm4^{Gt(VICTR20)7Lex}
Genetic Background	involves: 129S5/SvEvBrd * 129S6/SvEvTac * C57BL/6 * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mdm4^{Gt(VICTR20)7Lex} mutation (0 available); any Mdm4 mutation (191 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

embryonic lethality during organogenesis, incomplete penetrance ( J:166152 )

• fewer than expected mice are present at E10.5, E12.5, E13.5, and E14.5

embryo

abnormal embryo development ( J:166152 )

• mice are grossly abnormal

cellular

decreased cell proliferation ( J:166152 )

• in mouse embryonic fibroblasts

Allelic Composition	Mdm2^tm1Glo/Mdm2⁺ Mdm4^{Gt(VICTR20)7Lex}/Mdm4⁺ Trp53^tm3Wahl/Trp53^tm3Wahl
Genetic Background	involves: 129

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mdm2^tm1Glo mutation (0 available); any Mdm2 mutation (54 available)
Mdm4^{Gt(VICTR20)7Lex} mutation (0 available); any Mdm4 mutation (191 available)
Trp53^tm3Wahl mutation (0 available); any Trp53 mutation (232 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cellular

abnormal cell cycle ( J:108183 )

• cell cycle arrest in irradiate MEFs is improved compared to Trp53 single homozygous MEFs but is still not as robust as in wild-type MEFs

Allelic Composition	Mdm4^{Gt(VICTR20)7Lex}/Mdm4^{Gt(VICTR20)7Lex} Trp53^tm1Tyj/Trp53⁺
Genetic Background	involves: 129S2/SvPas * 129S5/SvEvBrd

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mdm4^{Gt(VICTR20)7Lex} mutation (0 available); any Mdm4 mutation (191 available)
Trp53^tm1Tyj mutation (12 available); any Trp53 mutation (232 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

preweaning lethality, complete penetrance ( J:77907 )

• no viable mice are found, no specific time of death is provided

embryo

decreased embryo size ( J:77907 )

• reduced in size compared to double heterozygous controls; however, this reduction is slight compared to mice homozygous for the Mdm4 mutation alone

growth/size/body

decreased embryo size ( J:77907 )

• reduced in size compared to double heterozygous controls; however, this reduction is slight compared to mice homozygous for the Mdm4 mutation alone

Allelic Composition	Mdm4^{Gt(VICTR20)7Lex}/Mdm4^{Gt(VICTR20)7Lex} Trp53^tm1Tyj/Trp53^tm1Tyj
Genetic Background	involves: 129S2/SvPas * 129S5/SvEvBrd

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

mortality/aging ( J:77907 )

N	• double homozygotes are viable, unlike mice homozygous for the Mdm4 allele alone

embryo

embryo phenotype ( J:77907 )

N	• appear indistinguishable from control littermates at E10.5, unlike mice homozygous for the Mdm4 mutation alone

cellular

abnormal cell cycle checkpoint function ( J:77907 )

• gamma-irradiation fails to produce an increase in the relative number of cells in G1 compared to S phase similar to what is seen in MEFs homozygous for the Trp53 allele alone

decreased cellular sensitivity to ultraviolet irradiation ( J:77907 )

• reduced sensitivity to UV-induced cell death in MEFs similar to cells homozygous for Trp53 alone

increased fibroblast proliferation ( J:77907 )

• similar to MEFs homozygous for the Trp53 allele alone, proliferation is increased relative to control cells

Allelic Composition	Mdm4^{Gt(VICTR20)7Lex}/Mdm4^{Gt(VICTR20)7Lex} Trp53^tm3Wahl/Trp53^tm3Wahl
Genetic Background	involves: 129S4/SvJae * 129S5/SvEvBrd

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mdm4^{Gt(VICTR20)7Lex} mutation (0 available); any Mdm4 mutation (191 available)
Trp53^tm3Wahl mutation (0 available); any Trp53 mutation (232 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

mortality/aging ( J:108183 )

N	• viable double homozygous mice are found in Mendelian proportions

cellular

abnormal cell cycle ( J:108183 )

• cell cycle arrest in irradiate MEFs is improved compared to Trp53 single homozygous MEFs but is still not as robust as in wild-type MEFs

decreased fibroblast proliferation ( J:108183 )

• cell proliferation in double homozygous MEFs is reduced by about 30% compared to Trp53 single homozygous MEFs

Allelic Composition	Mdm4^{Gt(VICTR20)7Lex}/Mdm4^{Gt(VICTR20)7Lex} Trp53^tm1.1Xlu/Trp53^tm1.1Xlu
Genetic Background	involves: 129S5/SvEvBrd * 129S6/SvEvTac * C57BL/6 * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mdm4^{Gt(VICTR20)7Lex} mutation (0 available); any Mdm4 mutation (191 available)
Trp53^tm1.1Xlu mutation (2 available); any Trp53 mutation (232 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

embryonic lethality during organogenesis, incomplete penetrance ( J:166152 )

• fewer than expected mice are present at E12.5, E13.5, and E14.5

• however, expected numbers of mice are present at E10.5

cellular

cellular phenotype ( J:166152 )

N	• mouse embryonic fibroblasts replicate normally in culture

Allelic Composition	Mdm4^{Gt(VICTR20)7Lex}/Mdm4⁺ Trp53^tm1.1Xlu/Trp53^tm1.1Xlu
Genetic Background	involves: 129S5/SvEvBrd * 129S6/SvEvTac * C57BL/6 * FVB/N

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

embryonic lethality during organogenesis, incomplete penetrance ( J:166152 )

• fewer than expected mice are present at E10.5, E12.5, E13.5, and E14.5

embryo

abnormal embryo development ( J:166152 )

• mice are grossly abnormal

embryonic growth retardation ( J:166152 )

• in 4 of 6 mice at E12.5

growth/size/body

embryonic growth retardation ( J:166152 )

• in 4 of 6 mice at E12.5

Allelic Composition	Mdm2^tm1Glo/Mdm2⁺ Mdm4^{Gt(VICTR20)7Lex}/Mdm4⁺ Trp53^tm1Wahl/Trp53^tm1Wahl
Genetic Background	involves: 129S5/SvEvBrd * 129S7/SvEvBrd * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mdm2^tm1Glo mutation (0 available); any Mdm2 mutation (54 available)
Mdm4^{Gt(VICTR20)7Lex} mutation (0 available); any Mdm4 mutation (191 available)
Trp53^tm1Wahl mutation (0 available); any Trp53 mutation (232 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cellular

abnormal cell cycle ( J:108183 )

• presence of one copy of Mdm2 partially restores the arrest response of Trp53^tm1Wahl; p21 protein levels are increased slightly more compared to homozygous Trp53^tm1Wahl, Mdm2^tm1Glo/+ or homozygous Trp53^tm1Wahl, Mdm4/+ heterozygotes

Allelic Composition	Mdm4^{Gt(VICTR20)7Lex}/Mdm4⁺ Trp53^tm1Wahl/Trp53^tm1Wahl
Genetic Background	involves: 129S5/SvEvBrd * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mdm4^{Gt(VICTR20)7Lex} mutation (0 available); any Mdm4 mutation (191 available)
Trp53^tm1Wahl mutation (0 available); any Trp53 mutation (232 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cellular

abnormal cell cycle ( J:108183 )

• presence of one copy of Mdm2 partially restores the arrest response of Trp53^tm1Wahl; p21 protein levels are modestly increased from homozygous Trp53^tm1Wahl mutant levels

Allelic Composition	Mdm4^{Gt(VICTR20)7Lex}/Mdm4^{Gt(VICTR20)7Lex} Trp53^tm1Wahl/Trp53^tm1Wahl
Genetic Background	involves: 129S5/SvEvBrd * C57BL/6

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cellular

abnormal cell cycle ( J:108183 )

• in double homozygous MEFs, irradiation did result in cell cycle arrest, but less efficiently than in wild-type cells; p21 protein levels are the highest of all the Trp53^tm1Wahl mutants analyzed

decreased cell proliferation ( J:108183 )

• loss of Mdm4 expression reduces the proliferation rate of Trp53^tm1Wahl-deficient cells

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