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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		NsdhlBpa-8H
bare patches 8 Harwell
MGI:1862021
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
ht1
 		NsdhlBpa-8H/Nsdhl+ involves: BALB/c * C3H/HeN MGI:3587824
ot2
 		NsdhlBpa-8H/Y involves: BALB/c * C3H/HeN MGI:3587823


Genotype
MGI:3587824
ht1
Allelic
Composition		 NsdhlBpa-8H/Nsdhl+
Genetic
Background		 involves: BALB/c * C3H/HeN
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
NsdhlBpa-8H mutation (2 available); any Nsdhl mutation (8 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
growth/size/body
decreased body size ( J:90559 , J:95508 )
• small at weaning age (J:90559)
• moderate dwarfing (J:95508)

pigmentation
irregular coat pigmentation ( J:90559 )
• striped appearance

integument
irregular coat pigmentation ( J:90559 )
• striped appearance
alopecia ( J:100224 )
• bare patches on skin with no hair
hyperkeratosis ( J:95508 , J:100224 )
(J:95508)
• hyperkeratotic eruptions at P5-7 (J:100224)
abnormal skin condition ( J:90559 , J:100224 )
• scarring on the skin is apparent at 8 days of age (J:90559)
(J:100224)




Genotype
MGI:3587823
ot2
Allelic
Composition		 NsdhlBpa-8H/Y
Genetic
Background		 involves: BALB/c * C3H/HeN
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
NsdhlBpa-8H mutation (2 available); any Nsdhl mutation (8 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
embryonic lethality during organogenesis, complete penetrance ( J:95508 )
• hemizygous male embryos die between E10.5 and E12.5

embryo
abnormal placenta labyrinth morphology ( J:95508 )
• labyrinthine layer is thinner and is disorganized
small placenta ( J:95508 )
• smaller than in controls
• significantly reduced thickness compared to controls
pale yolk sac ( J:95508 )
• yolk sacs appear pale
abnormal vitelline vascular remodeling ( J:95508 )
• fewer and/or narrower blood vessels in yolk sac, and exhibit abnormal remodeling and vessel branching

growth/size/body
embryonic growth retardation ( J:95508 )
decreased embryo size ( J:95508 )

cardiovascular system
pericardial effusion ( J:95508 )
• significant effusion
hemorrhage ( J:95508 )
• fetal hemorrhage

nervous system
abnormal forebrain morphology ( J:95508 )
• small forebrain

homeostasis/metabolism
pericardial effusion ( J:95508 )
• significant effusion

integument




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory