About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		NsdhlBpa-8H
bare patches 8 Harwell
MGI:1862021
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
ht1
 		NsdhlBpa-8H/Nsdhl+ involves: BALB/c * C3H/HeN MGI:3587824
ot2
 		NsdhlBpa-8H/Y involves: BALB/c * C3H/HeN MGI:3587823


Genotype
MGI:3587824
ht1
Allelic
Composition		 NsdhlBpa-8H/Nsdhl+
Genetic
Background		 involves: BALB/c * C3H/HeN
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
NsdhlBpa-8H mutation (2 available); any Nsdhl mutation (10 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
growth/size/body
decreased body size ( J:95508 , J:90559 )
• moderate dwarfing (J:95508)
• small at weaning age (J:90559)

pigmentation
irregular coat pigmentation ( J:90559 )
• striped appearance

integument
irregular coat pigmentation ( J:90559 )
• striped appearance
alopecia ( J:100224 )
• bare patches on skin with no hair
hyperkeratosis ( J:95508 , J:100224 )
(J:95508)
• hyperkeratotic eruptions at P5-7 (J:100224)
abnormal skin condition ( J:100224 , J:90559 )
(J:100224)
• scarring on the skin is apparent at 8 days of age (J:90559)




Genotype
MGI:3587823
ot2
Allelic
Composition		 NsdhlBpa-8H/Y
Genetic
Background		 involves: BALB/c * C3H/HeN
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
NsdhlBpa-8H mutation (2 available); any Nsdhl mutation (10 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
embryonic lethality during organogenesis, complete penetrance ( J:95508 )
• hemizygous male embryos die between E10.5 and E12.5

embryo
abnormal placenta labyrinth morphology ( J:95508 )
• labyrinthine layer is thinner and is disorganized
small placenta ( J:95508 )
• smaller than in controls
• significantly reduced thickness compared to controls
pale yolk sac ( J:95508 )
• yolk sacs appear pale
abnormal vitelline vascular remodeling ( J:95508 )
• fewer and/or narrower blood vessels in yolk sac, and exhibit abnormal remodeling and vessel branching

growth/size/body
embryonic growth retardation ( J:95508 )
decreased embryo size ( J:95508 )

cardiovascular system
pericardial effusion ( J:95508 )
• significant effusion
hemorrhage ( J:95508 )
• fetal hemorrhage

nervous system
abnormal forebrain morphology ( J:95508 )
• small forebrain

homeostasis/metabolism
pericardial effusion ( J:95508 )
• significant effusion

integument




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
01/06/2026
MGI 6.24 		The Jackson Laboratory