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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Prlrtm1Cnp
targeted mutation 1, Paul A Kelly
MGI:1888377
Summary 13 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Prlrtm1Cnp/Prlrtm1Cnp either: (involves: 129/Sv * 129P2/OlaHsd) or (involves: 129P2/OlaHsd * C57BL/6) MGI:2660641
hm2
Prlrtm1Cnp/Prlrtm1Cnp involves: 129/Sv * 129P2/OlaHsd MGI:4431029
hm3
Prlrtm1Cnp/Prlrtm1Cnp involves: 129/Sv * 129P2/OlaHsd * C57BL/6 MGI:4430505
hm4
Prlrtm1Cnp/Prlrtm1Cnp involves: 129P2/OlaHsd MGI:2660654
hm5
Prlrtm1Cnp/Prlrtm1Cnp involves: 129P2/OlaHsd * 129S2/SvPas MGI:4430627
hm6
Prlrtm1Cnp/Prlrtm1Cnp involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6 MGI:4430635
ht7
Prlrtm1Cnp/Prlr+ B6.129P2-Prlrtm1Cnp/J MGI:4430502
ht8
Prlrtm1Cnp/Prlr+ either: (involves: 129/Sv * 129P2/OlaHsd) or (involves: 129P2/OlaHsd * C57BL/6) MGI:2660642
ht9
Prlrtm1Cnp/Prlr+ involves: 129P2/OlaHsd MGI:2660655
ht10
Prlrtm1Cnp/Prlr+ involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6 MGI:4430637
cx11
Prlrtm1Cnp/Prlr+
Socs1tm1Wehi/Socs1+
involves: 129P2/OlaHsd * 129S1/Sv * 129S2/SvPas * C57BL/6 MGI:4430639
cx12
Prlrtm1Cnp/Prlrtm1Cnp
Tg(C3-1-TAg)cJeg/0
involves: 129P2/OlaHsd * 129S2/SvPas * FVB/N MGI:4431014
cx13
Ghrhrlit/Ghrhrlit
Prlrtm1Cnp/Prlrtm1Cnp
involves: 129P2/OlaHsd * C57BL/6J MGI:4431047


Genotype
MGI:2660641
hm1
Allelic
Composition
Prlrtm1Cnp/Prlrtm1Cnp
Genetic
Background
either: (involves: 129/Sv * 129P2/OlaHsd) or (involves: 129P2/OlaHsd * C57BL/6)
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Prlrtm1Cnp mutation (2 available); any Prlr mutation (44 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
behavior/neurological
• females showed increased mating frequency

endocrine/exocrine glands
• reduced number of primary follicles

reproductive system
• immature oocytes were released from the ovary
• reduced number of primary follicles
• fertilization was impaired
• defective pre-implantation embryonic development
• mating did not induce pseudopregnancy
• fewer than normal eggs are ovulated
• the uterus was refractory to implantation, though occasional implanted blastocysts were observed
• fertilized single and two-cell stage embryos were viable when reimplanted into pseudopregnant (C57BL/6 x CBA)F1 hosts
• Background Sensitivity: on a mixed background, 3 of 15 males were infertile
• Background Sensitivity: on a mixed background, 5 of 15 males were showed impaired fertility

embryo
• the uterus was refractory to implantation, though occasional implanted blastocysts were observed
• fertilized single and two-cell stage embryos were viable when reimplanted into pseudopregnant (C57BL/6 x CBA)F1 hosts

cellular
• immature oocytes were released from the ovary




Genotype
MGI:4431029
hm2
Allelic
Composition
Prlrtm1Cnp/Prlrtm1Cnp
Genetic
Background
involves: 129/Sv * 129P2/OlaHsd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Prlrtm1Cnp mutation (2 available); any Prlr mutation (44 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
reproductive system
N
• Background Sensitivity: on a predominantly 129/Sv background, male mice exhibit normal reproductive morphology and fertility

homeostasis/metabolism
N
• Background Sensitivity: on a predominantly 129/Sv background, follicle stimulating hormone, luteinizing hormone, and testosterone plasma levels are normal
• serum-free T4 levels are lower than in wild-type mice

endocrine/exocrine glands
• at 2, 4, and 5 months of age, thyroid gland weight is increased compared to in wild-type mice
• mice exhibit an increase in mucus cell-like structures in the thyroid gland compared to in wild-type mice
• mice develop medullary thyroid carcinomas unlike wild-type mice

neoplasm
• mice develop medullary thyroid carcinomas unlike wild-type mice

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
familial medullary thyroid carcinoma DOID:0050547 OMIM:155240
J:101609




Genotype
MGI:4430505
hm3
Allelic
Composition
Prlrtm1Cnp/Prlrtm1Cnp
Genetic
Background
involves: 129/Sv * 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Prlrtm1Cnp mutation (2 available); any Prlr mutation (44 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
skeleton
• at 4 months of age as measured by bone mineral density and bone mineral content
• bone formation is decreased 60% compared to in wild-type mice
• the distance between mineralization fronts is decreased compared to in wild-type mice
• trabecular and cortical long bone mineral apposition rates are less than in wild-type mice
• however, mineralizing and osteoblast surfaces are normal
• in the calvaria at E18.5

homeostasis/metabolism




Genotype
MGI:2660654
hm4
Allelic
Composition
Prlrtm1Cnp/Prlrtm1Cnp
Genetic
Background
involves: 129P2/OlaHsd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Prlrtm1Cnp mutation (2 available); any Prlr mutation (44 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
behavior/neurological
N
• mice exhibit normal spatial learning in a Morris water maze test
• virgin females fail to develop full maternal behavior towards fostered pups even after 6 days of exposure compared with wild-type mice that require only 1-2 days of exposure
• virgin females take 6 days of daily exposure sessions to fostered pups to retrieve them if they retrieve them at all compared with 1 or 2 daily exposure sessions for wild-type mice

growth/size/body
• female mice exhibit decreased body weight compared with wild-type mice
• however, male mice exhibit normal body weight
• after 4 months, female mice exhibit deficient weight gain compared with wild-type mice

skeleton
• slightly in female mice but not male mice

taste/olfaction
N
• mice exhibit normal olfaction

integument
• mice have longer hair compared with wild-type mice
• slightly after G2
• after G2, hair replacement is advanced compared to in wild-type mice
• after G2, mice no longer exhibit sexual dimorphism in fiber eruption unlike in wild-type mice




Genotype
MGI:4430627
hm5
Allelic
Composition
Prlrtm1Cnp/Prlrtm1Cnp
Genetic
Background
involves: 129P2/OlaHsd * 129S2/SvPas
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Prlrtm1Cnp mutation (2 available); any Prlr mutation (44 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
reproductive system
• prostate epithelial content is reduced compared to in wild-type mice
• however, no difference is observed in castrated mice
• ventral prostate weight in mature mice up to 1 year of age is increased compared to in wild-type mice
• in mature, but not young, mice
• more mice exhibit total infertility than wild-type mice
• latency to first litter conceived by male mice is delayed compared to for wild-type mice

vision/eye
N
• mice exhibit normal IgA tear composition and strain sensitivity to conjunctivitis
• male mice exhibit a small reduction in lacrimal gland acini per field compared to in wild-type mice due to a decrease in acinar area associated with an increase in acinar cell density
• however, the lacrimal gland in female mice is normal and castration of male mice restores normal lacrimal gland morphology

endocrine/exocrine glands
• male mice exhibit a small reduction in lacrimal gland acini per field compared to in wild-type mice due to a decrease in acinar area associated with an increase in acinar cell density
• however, the lacrimal gland in female mice is normal and castration of male mice restores normal lacrimal gland morphology
• prostate epithelial content is reduced compared to in wild-type mice
• however, no difference is observed in castrated mice
• ventral prostate weight in mature mice up to 1 year of age is increased compared to in wild-type mice
• in mature, but not young, mice
• male mice exhibit a 10% increase in acinar cell density compared with wild-type mice
• however, the Harderian gland in female mice is normal
• male and female mice exhibit a decrease in solid porphyrin accretions compared with wild-type mice




Genotype
MGI:4430635
hm6
Allelic
Composition
Prlrtm1Cnp/Prlrtm1Cnp
Genetic
Background
involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Prlrtm1Cnp mutation (2 available); any Prlr mutation (44 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
endocrine/exocrine glands
• islet density is increased in weanling males and adult male and female mice compared to in wild-type mice
• beta cell fraction and mass are reduced in male and female mice compared to in wild-type mice
• islet size in weanling males is decreased compared to in wild-type mice
• however, adult male and female mice exhibit normal islet size
• islet insulin content is reduced compared to in wild-type cells
• insulin secretion in response to glucose is blunted compared to in similarly treated wild-type mice

growth/size/body
• in female, but not male mice, at 27 to 37 weeks of age
• in female and male mice at 42 to 76 weeks of age
• female mice exhibit a greater reduction in body weight than male mice
• in male and female mice

homeostasis/metabolism
• islet insulin content is reduced compared to in wild-type cells
• insulin secretion in response to glucose is blunted compared to in similarly treated wild-type mice
• in female, but not male, mice at 7 to 9 months of age

adipose tissue
• in male and female mice at 8 to 9 months of age




Genotype
MGI:4430502
ht7
Allelic
Composition
Prlrtm1Cnp/Prlr+
Genetic
Background
B6.129P2-Prlrtm1Cnp/J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Prlrtm1Cnp mutation (2 available); any Prlr mutation (44 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• at gestation day 7, mated females exhibit less of an increase in forebrain neurogenesis compared with mated wild-type mice

cellular
• at gestation day 7, mated females exhibit less of an increase in forebrain neurogenesis compared with mated wild-type mice




Genotype
MGI:2660642
ht8
Allelic
Composition
Prlrtm1Cnp/Prlr+
Genetic
Background
either: (involves: 129/Sv * 129P2/OlaHsd) or (involves: 129P2/OlaHsd * C57BL/6)
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Prlrtm1Cnp mutation (2 available); any Prlr mutation (44 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
behavior/neurological
• some mothers scattered their pups, often burying them in sawdust
• when the mother reformed the nest, a pup was often left outside and not retrieved, whereas the others were suckled

endocrine/exocrine glands
• impaired development after first, but not subsequent, pregnancies
• failure of lactation attributable after first, but not subsequent, pregancies

integument
• impaired development after first, but not subsequent, pregnancies
• failure of lactation attributable after first, but not subsequent, pregancies




Genotype
MGI:2660655
ht9
Allelic
Composition
Prlrtm1Cnp/Prlr+
Genetic
Background
involves: 129P2/OlaHsd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Prlrtm1Cnp mutation (2 available); any Prlr mutation (44 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
behavior/neurological
N
• mice exhibit normal spatial learning in a Morris water maze test
• virgin female require 4 days to develop full maternal behavior towards fostered pups compared with 1 or 2 days for wild-type mice
• virgin females take 4 to 5 days of daily exposure sessions to fostered pups to retrieve them compared with 1 or 2 daily exposure sessions for wild-type mice

taste/olfaction
N
• mice exhibit normal olfaction

integument
• intermediate timing of molting relative to homozygotes and wild-type mice




Genotype
MGI:4430637
ht10
Allelic
Composition
Prlrtm1Cnp/Prlr+
Genetic
Background
involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Prlrtm1Cnp mutation (2 available); any Prlr mutation (44 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
endocrine/exocrine glands
• at 2 days postpartum, lobuloalveolar structures are underdeveloped compared to in wild-type mice

integument
• at 2 days postpartum, lobuloalveolar structures are underdeveloped compared to in wild-type mice




Genotype
MGI:4430639
cx11
Allelic
Composition
Prlrtm1Cnp/Prlr+
Socs1tm1Wehi/Socs1+
Genetic
Background
involves: 129P2/OlaHsd * 129S1/Sv * 129S2/SvPas * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Prlrtm1Cnp mutation (2 available); any Prlr mutation (44 available)
Socs1tm1Wehi mutation (3 available); any Socs1 mutation (30 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
endocrine/exocrine glands
N
• unlike in Prlrtm1Cnp heterozygotes, lobuloalveolar structure development at 2 days postpartum is normal

reproductive system
N
• unlike in Prlrtm1Cnp heterozygotes, lobuloalveolar structure development at 2 days postpartum is normal




Genotype
MGI:4431014
cx12
Allelic
Composition
Prlrtm1Cnp/Prlrtm1Cnp
Tg(C3-1-TAg)cJeg/0
Genetic
Background
involves: 129P2/OlaHsd * 129S2/SvPas * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Prlrtm1Cnp mutation (2 available); any Prlr mutation (44 available)
Tg(C3-1-TAg)cJeg mutation (2 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
neoplasm
• mice exhibit a decrease in prostate intraepithelial neoplasia (PIN) in the ventral lobe compared with Tg(C3-1-TAg)cJeg mice
• however, PIN development in the dorsal lobe is the same as in Tg(C3-1-TAg)cJeg mice and mice do not develop prostate tumors

endocrine/exocrine glands
• mice exhibit a decrease in prostate intraepithelial neoplasia (PIN) in the ventral lobe compared with Tg(C3-1-TAg)cJeg mice
• however, PIN development in the dorsal lobe is the same as in Tg(C3-1-TAg)cJeg mice and mice do not develop prostate tumors

reproductive system
• mice exhibit a decrease in prostate intraepithelial neoplasia (PIN) in the ventral lobe compared with Tg(C3-1-TAg)cJeg mice
• however, PIN development in the dorsal lobe is the same as in Tg(C3-1-TAg)cJeg mice and mice do not develop prostate tumors




Genotype
MGI:4431047
cx13
Allelic
Composition
Ghrhrlit/Ghrhrlit
Prlrtm1Cnp/Prlrtm1Cnp
Genetic
Background
involves: 129P2/OlaHsd * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ghrhrlit mutation (3 available); any Ghrhr mutation (34 available)
Prlrtm1Cnp mutation (2 available); any Prlr mutation (44 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
homeostasis/metabolism
• at P7 and 3 months of age, serum glucose levels are lower than in wild-type mice unlike either single homozygote
• at 12 months, female mice exhibit decreased serum glucose level compared with wild-type mice or Prlrtm1Cnp homozygotes
• at 12 months in fasting male mice
• at P7, plasma insulin levels are decreased compared to in wild-type mice
• adult female mice exhibit decreased fasting insulin levels compared to in wild-type mice
• in fasted female mice and fed male mice
• in aged male mice
• at 12 and 18 months in male mice

growth/size/body
• at P7, mice weigh less than wild-type mice unlike either single homozygote
• however, by 600 days male mice exhibit normal body weight
• up to 1 year of age, female mice exhibit a reduced body weight gain compared with wild-type mice that is similar to in Ghrhrlit female mice
• until 160 days of age, male mice exhibit decreased body weight gain compared with wild-type mice

skeleton

adipose tissue
• body fat as a percent of body weight in male mice is increased compared to in wild-type mice
• aging female mice exhibit increased percent body fat compared with wild-type mice

behavior/neurological
• in male mice at 15 months of age

limbs/digits/tail





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last database update
11/19/2024
MGI 6.24
The Jackson Laboratory