Analysis Tools
behavior/neurological
| N |
• no overt behavioral abnormalities, including reflexes, anxiety related behaviors, sensorimotor responses, fear conditioning and exploratory activity
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• motor learning performance is impaired on the accelerating rotarod test; mutant mice perform similarly to controls in the first two training sessions, but do not improve from trial 2 to 3 as do control mice
• mutant mice perform similar to controls in coordination, strength and balance tests such as vertical pole and hanging wire test
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homeostasis/metabolism
| N |
• T4 plasma levels are similar to controls
• plasma glucose levels are similar to controls
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• plasma corticosterone levels are significantly elevated compared to controls
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• plasma growth hormone levels are 3 times greater than controls
but body weight is normal
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nervous system
| N |
• no gross abnormalities of brain morphology, including the characteristic layering of cells in the cerebellar cortex
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