Analysis Tools|
Allele Symbol Allele Name Allele ID |
Scarb1tm1Kri targeted mutation 1, Monty Krieger MGI:1888384 |
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| Summary |
6 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• reendothelialization is delayed compared to in wild-type mice following injury to the carotid artery
• mice exhibit a 44% larger area of non-reendothelialized carotid artery following injury compared to in wild-type mice
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• reendothelialization is delayed compared to in wild-type mice following injury to the carotid artery
• mice exhibit a 44% larger area of non-reendothelialized carotid artery following injury compared to in wild-type mice
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• the occasional offspring produced by homozygous mothers die soon after birth
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• eggs harvested at ~16 h after hCG administration show abnormally high levels of unesterified cholesterol relative to control eggs, as assessed by filipin staining
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• plasma total cholesterol is abnormally high
• most of the cholesterol is found as abnormally large particles
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• eggs harvested at ~16 h after hCG administration show abnormally high levels of unesterified cholesterol relative to control eggs, as assessed by filipin staining
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• plasma concentrations are 125% of control values
• concentration increase is due to formation of large particles containing apolipoprotein A-1
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• some superovulated oocytes have an abnormal morphology
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• ~19% of the ovulated eggs harvested ~16 h after human chorionic gonadotropin (hCG)-induced superovulation exhibit an abnormal, nonrefractile morphology typical of dead eggs
• death rate of eggs increases to 53% at 18-19 h post-hCG injection
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• an increased number of oocytes exhibit spontaneous meiotic progression beyond metaphase II (MII) arrest at ~16 h (73%) and ~20 h (93%) after hCG-induced superovulation
• most ovulated eggs failing to arrest at MII progress to pronuclear, metaphase III (MIII), and anaphase/telophase III stages and show reduced MPF and MAPK activities
• however, the rate at and extent to which oocytes undergo germinal vesicle breakdown (GVBD) and complete the first meiotic division (first polar body extrusion) are normal
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• inactivation of the apolipoprotein A-1 gene or administration of the cholesterol-lowering drug probucol restored fertility
(J:73138)
• only occasionally will a pup be born
(J:105226)
• inactivation of the apolipoprotein A-1 gene or administration of the cholesterol-lowering drug probucol restored fertility
(J:105226)
• female infertility is caused, at least in part, by excess cholesterol in eggs inducing premature egg activation
(J:216748)
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• ovulated eggs show spontaneous escape from MII arrest, reduced MPF and MAPK activities, and aberrant progression to haploid pronuclear, metaphase III, and anaphase/telophase III stages, similar to normal ovulated eggs after chemical activation
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• ~16 h after human chorionic gonadotropin (hCG)-induced superovulation, any remaining viable ovulated eggs are unable to be fertilized or develop into viable pups
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• red blood cells with cytoplasmic irregularities
• mitochondria present in about 15% of red blood cells
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• sometimes
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• some superovulated oocytes have an abnormal morphology
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• ~19% of the ovulated eggs harvested ~16 h after human chorionic gonadotropin (hCG)-induced superovulation exhibit an abnormal, nonrefractile morphology typical of dead eggs
• death rate of eggs increases to 53% at 18-19 h post-hCG injection
|
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• an increased number of oocytes exhibit spontaneous meiotic progression beyond metaphase II (MII) arrest at ~16 h (73%) and ~20 h (93%) after hCG-induced superovulation
• most ovulated eggs failing to arrest at MII progress to pronuclear, metaphase III (MIII), and anaphase/telophase III stages and show reduced MPF and MAPK activities
• however, the rate at and extent to which oocytes undergo germinal vesicle breakdown (GVBD) and complete the first meiotic division (first polar body extrusion) are normal
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• eggs harvested at ~16 h after hCG administration show abnormally high levels of unesterified cholesterol relative to control eggs, as assessed by filipin staining
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• in vitro development of zygotes arrests by the 2 cell stage
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• the majority of harvested one cell zygotes had an abnormal, nonrefractile morphology
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• cholesterol content is 72% lower than normal
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• plasma cholesterol concentration increased by ~31%
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• cholesterol content decreased by 42%
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
Apoetm1Unc/Apoetm1Unc Scarb1tm1Kri/Scarb1tm1Kri mice develop occlusive, atherosclerotic coronary artery disease
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• median survival time of approximately 6 weeks
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• in the coronary arteries
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• coronary artery occlusion
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• at 31 days of age small myocardial infarctions are seen and by 43 days of age extensive myocardial infarctions are present
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• develop occlusive, atherosclerotic coronary artery disease after 21 days of age
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• increase in the heart to body weight ratio in mice over 21 days of age
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• increase in the heart to body weight ratio in mice over 21 days of age
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Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
| coronary artery disease | DOID:3393 |
OMIM:300464 OMIM:607339 OMIM:608316 OMIM:608318 OMIM:608320 OMIM:610947 OMIM:611139 OMIM:612030 OMIM:614293 |
J:201999 | |
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• abnormally large but with normal cellular hemoglobin levels
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• non uniform cell populations
• target-like appearance
• intracellular inclusions
• mitochondria present
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• often spiculated
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• reticulocytes appear in the circulation
• a systemic process interferes with reticulocyte maturation
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 11/12/2024 MGI 6.24 |
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