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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Stat6tm1Gru
targeted mutation 1, Michael J Grusby
MGI:1888385
Summary 14 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Stat6tm1Gru/Stat6tm1Gru 129S2/SvPas-Stat6tm1Gru MGI:3620967
hm2
 		Stat6tm1Gru/Stat6tm1Gru C.129S2-Stat6tm1Gru MGI:5301101
hm3
 		Stat6tm1Gru/Stat6tm1Gru C.129S2-Stat6tm1Gru/J MGI:3580504
hm4
 		Stat6tm1Gru/Stat6tm1Gru involves: 129S2/SvPas MGI:3851530
hm5
 		Stat6tm1Gru/Stat6tm1Gru involves: 129S2/SvPas * BALB/c MGI:5301100
hm6
 		Stat6tm1Gru/Stat6tm1Gru involves: 129S2/SvPas * C57BL/6 MGI:5301102
cx7
 		Cd28tm1Mak/Cd28tm1Mak
Stat6tm1Gru/Stat6tm1Gru 		C.129S2(B6)-Cd28tm1Mak Stat6tm1Gru MGI:3047086
cx8
 		Foxp3tm1Tch/Y
Stat6tm1Gru/Stat6tm1Gru 		C.129-Stat6tm1Gru Foxp3tm1Tch MGI:3697518
cx9
 		Il4tm1.1Wep/Il4+
Stat6tm1Gru/Stat6tm1Gru 		C.129-Stat6tm1Gru Il4tm1.1Wep MGI:3818430
cx10
 		Il4tm1.1Wep/Il4tm1.1Wep
Stat6tm1Gru/Stat6tm1Gru 		C.129-Stat6tm1Gru Il4tm1.1Wep MGI:3818431
cx11
 		Fbn1Tsk/Fbn1+
Stat6tm1Gru/Stat6tm1Gru 		involves: 129S2/SvPas * C57BL/10 * DBA/2 MGI:5301099
cx12
 		Stat6tm1Gru/Stat6+
Tg(Scgb1a1-Il13)2Eli/? 		involves: 129S2/SvPas * C57BL/6 * CBA MGI:3832413
cx13
 		Stat6tm1Gru/Stat6tm1Gru
Tg(Scgb1a1-Il13)2Eli/? 		involves: 129S2/SvPas * C57BL/6 * CBA MGI:3832414
cx14
 		Stat6tm1Gru/Stat6tm1Gru
Tg(Scgb1a1-Il13)2Eli/?
Tg(Scgb1a1-STAT6)1Erle/? 		involves: 129S2/SvPas * C57BL/6 * CBA * FVB MGI:3832416


Genotype
MGI:3620967
hm1
Allelic
Composition		 Stat6tm1Gru/Stat6tm1Gru
Genetic
Background		 129S2/SvPas-Stat6tm1Gru
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Stat6tm1Gru mutation (4 available); any Stat6 mutation (53 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased T cell proliferation ( J:31932 )
• IL4 stimulated lymph node cells exhibit an impaired proliferative response
abnormal T-helper 2 cell differentiation ( J:31932 )
• impaired ability of T lymphocytes to differentiate into Th2 cells
decreased IgE level ( J:31932 )
• anti-IgD immunized mice do not show an increase in IgE levels although IgG1 and IgG2a levels increase similar to wildtype sera levels
abnormal interleukin secretion ( J:31932 )
• spleen cells stimulated with anti-CD3 and cultured with anti-IFNG and IL4 or IL13 do not produce IL4 and IL5

hematopoietic system
decreased T cell proliferation ( J:31932 )
• IL4 stimulated lymph node cells exhibit an impaired proliferative response
abnormal T-helper 2 cell differentiation ( J:31932 )
• impaired ability of T lymphocytes to differentiate into Th2 cells
decreased IgE level ( J:31932 )
• anti-IgD immunized mice do not show an increase in IgE levels although IgG1 and IgG2a levels increase similar to wildtype sera levels

cellular
decreased T cell proliferation ( J:31932 )
• IL4 stimulated lymph node cells exhibit an impaired proliferative response




Genotype
MGI:5301101
hm2
Allelic
Composition		 Stat6tm1Gru/Stat6tm1Gru
Genetic
Background		 C.129S2-Stat6tm1Gru
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Stat6tm1Gru mutation (4 available); any Stat6 mutation (53 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
neoplasm
decreased metastatic potential ( J:65894 )
• metastasis to lungs of 4T1mammary carcinoma cells is significantly reduced
• CD8+ cell depletion leads to increased metastasis to lungs
abnormal tumor susceptibility ( J:65894 )
• growth rate of injected 4T1mouse mammary carcinoma cells is slowed
• CD8+ cell depletion leads to rapid mammary tumor growth

immune system
abnormal leukocyte migration ( J:74497 )
• only minor peribronchial leukocyte accumulation in response to chronic Aspergillus fumigatus infection
• delayed presence of T cells in bronchoalveolar lavage fluid with chronic Aspergillus fumigatus infection
impaired eosinophil recruitment ( J:66222 )
• fewer eosinophils in bronchoalveolar fluid of OVA sensitized mice than in controls although still elevated
abnormal cytotoxic T cell physiology ( J:65894 )
• develop significant levels of cytotoxic lymphocytes specific for 4T1mouse mammary carcinoma cells
decreased IgE level ( J:66222 , J:74497 )
• no detectable IgE whether OVA challenged or not (J:66222)
• chronic Aspergillus fumigatus infection fails to elicit serum IgE (J:74497)
decreased IgG1 level ( J:66222 )
• reduced OVA specific IgG1
increased IgG2a level ( J:66222 )
• increased OVA specific IgG2a
abnormal circulating interleukin-4 level ( J:66222 )
• levels fail to increase after antigen challenge
abnormal circulating interleukin-5 level ( J:66222 )
• levels fail to increase after antigen challenge

respiratory system
abnormal respiratory epithelium morphology ( J:66222 , J:74497 )
• no increase of mucus in airway epithelial cells with antigen exposure (J:66222)
abnormal airway responsiveness ( J:66222 , J:74497 )
• OVA sensitized mice fail to develop airway hyperresponsiveness in response to acetylcholine (J:66222)
• airway hyper-responsiveness develops very slowly in response to chronic Aspergillus fumigatus infection compared to controls (J:74497)

homeostasis/metabolism
increased circulating creatine level ( J:84825 )
• higher levels after kidney ischemia
abnormal circulating interleukin-4 level ( J:66222 )
• levels fail to increase after antigen challenge
abnormal circulating interleukin-5 level ( J:66222 )
• levels fail to increase after antigen challenge
decreased core body temperature ( J:178294 )
• Background Sensitivity: drops when exposed to 4C
abnormal noradrenaline level ( J:178294 )
• noradrenaline content of adipose tissue is reduced 50-60% with cold exposure
decreased fatty acids level ( J:178294 )
• reduced circulating free fatty acids when exposed to 4C

renal/urinary system

cellular
abnormal leukocyte migration ( J:74497 )
• only minor peribronchial leukocyte accumulation in response to chronic Aspergillus fumigatus infection
• delayed presence of T cells in bronchoalveolar lavage fluid with chronic Aspergillus fumigatus infection

hematopoietic system
abnormal leukocyte migration ( J:74497 )
• only minor peribronchial leukocyte accumulation in response to chronic Aspergillus fumigatus infection
• delayed presence of T cells in bronchoalveolar lavage fluid with chronic Aspergillus fumigatus infection
impaired eosinophil recruitment ( J:66222 )
• fewer eosinophils in bronchoalveolar fluid of OVA sensitized mice than in controls although still elevated
decreased IgE level ( J:66222 , J:74497 )
• no detectable IgE whether OVA challenged or not (J:66222)
• chronic Aspergillus fumigatus infection fails to elicit serum IgE (J:74497)
decreased IgG1 level ( J:66222 )
• reduced OVA specific IgG1
increased IgG2a level ( J:66222 )
• increased OVA specific IgG2a
abnormal cytotoxic T cell physiology ( J:65894 )
• develop significant levels of cytotoxic lymphocytes specific for 4T1mouse mammary carcinoma cells




Genotype
MGI:3580504
hm3
Allelic
Composition		 Stat6tm1Gru/Stat6tm1Gru
Genetic
Background		 C.129S2-Stat6tm1Gru/J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Stat6tm1Gru mutation (4 available); any Stat6 mutation (53 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal CD4-positive T cell differentiation ( J:204829 )
• fewer IL4+ and IL9+ cells following differentiation towards Th9 lineage
abnormal CD8-positive, alpha beta T cell morphology ( J:125259 )
• IL-4 is unable to prevent decreases in CD8 expression during overnight cultures
abnormal humoral immune response ( J:107370 )
• neutralizing antibody titer higher than control following HSV-1 vaccination
decreased IgA level ( J:107370 )
• following HSV-1 vaccination
decreased IgG3 level ( J:107370 )
• decrease in IgG3 level following HSV-1 vaccination
• IgG2a and IgG2b levels remain similar to control
decreased IgM level ( J:107370 )
• following HSV-1 vaccination
increased interferon-gamma secretion ( J:107370 )
• HSV-1 vaccinated cultured splenocytes secrete high levels of IFNG without stimulation; control cells secret IFNG only when stimulated
increased interleukin-2 secretion ( J:107370 )
• cultured splenocytes secrete high levels of IL2 regardless of HSV-1 stimulation or vaccination; control cells secret IL2 only when stimulated and vaccinated
decreased interleukin-4 secretion ( J:107370 )
• cultured splenocytes do not secrete IL4 when stimulated
decreased susceptibility to Herpesvirales infection ( J:107370 )
• increased clearance of virus following HSV-1 infection as compared to controls
• reduced susceptibility to corneal scarring and blepharitis following HSV-1 infection as compared to controls

hematopoietic system
abnormal CD4-positive T cell differentiation ( J:204829 )
• fewer IL4+ and IL9+ cells following differentiation towards Th9 lineage
abnormal CD8-positive, alpha beta T cell morphology ( J:125259 )
• IL-4 is unable to prevent decreases in CD8 expression during overnight cultures
decreased IgA level ( J:107370 )
• following HSV-1 vaccination
decreased IgG3 level ( J:107370 )
• decrease in IgG3 level following HSV-1 vaccination
• IgG2a and IgG2b levels remain similar to control
decreased IgM level ( J:107370 )
• following HSV-1 vaccination




Genotype
MGI:3851530
hm4
Allelic
Composition		 Stat6tm1Gru/Stat6tm1Gru
Genetic
Background		 involves: 129S2/SvPas
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Stat6tm1Gru mutation (4 available); any Stat6 mutation (53 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal cytokine secretion ( J:112600 )
• T cells from mice immunized with keyhole limpet hemocyanin (KLH) in CFA (conjugated Freund's adjuvant) produce less IL-4 and interferon gamma than wild-type in response to KLH restimulation; IL-17a levels are comparable to controls

reproductive system
abnormal mammary gland growth during pregnancy ( J:184505 )
• decrease in alveologenesis at 5dG but not at 15dG

cellular
decreased mammary gland epithelial cell proliferation ( J:184505 )
• decrease in the proliferative potential of luminal progenitor cells in vitro

endocrine/exocrine glands
decreased mammary gland epithelial cell proliferation ( J:184505 )
• decrease in the proliferative potential of luminal progenitor cells in vitro
abnormal mammary gland morphology ( J:184505 )
• increase in the population of cells expressing GATA3, ESR1, and PGR and absence of cells expressing STAT5
abnormal mammary gland growth during pregnancy ( J:184505 )
• decrease in alveologenesis at 5dG but not at 15dG
abnormal mammary gland epithelium morphology ( J:184505 )
• increase in the number of luminal progenitor cells

integument
decreased mammary gland epithelial cell proliferation ( J:184505 )
• decrease in the proliferative potential of luminal progenitor cells in vitro
abnormal mammary gland morphology ( J:184505 )
• increase in the population of cells expressing GATA3, ESR1, and PGR and absence of cells expressing STAT5
abnormal mammary gland growth during pregnancy ( J:184505 )
• decrease in alveologenesis at 5dG but not at 15dG
abnormal mammary gland epithelium morphology ( J:184505 )
• increase in the number of luminal progenitor cells




Genotype
MGI:5301100
hm5
Allelic
Composition		 Stat6tm1Gru/Stat6tm1Gru
Genetic
Background		 involves: 129S2/SvPas * BALB/c
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Stat6tm1Gru mutation (4 available); any Stat6 mutation (53 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
homeostasis/metabolism
increased circulating tumor necrosis factor level ( J:85386 )
• serum TNF alpha levels increase 2-3 fold after ConA injection
abnormal circulating alanine transaminase level ( J:85386 )
• ConA injection fails to cause elevated alanine aminotransaminase levels as it does in controls

liver/biliary system
liver/biliary system phenotype ( J:85386 )
N
• liver necrosis fails to develop after ConA injection

immune system
immune system phenotype ( J:85386 )
N
• IL4 levels fail to increase after ConA injection
impaired eosinophil chemotaxis ( J:85386 )
• attenuated infiltration of liver after ConA injection compared to controls
impaired neutrophil chemotaxis ( J:85386 )
• attenuated infiltration of liver after ConA injection compared to controls
abnormal macrophage physiology ( J:85386 )
• lessened macrophage death after ConA injection compared to controls
increased circulating tumor necrosis factor level ( J:85386 )
• serum TNF alpha levels increase 2-3 fold after ConA injection
abnormal acute inflammation ( J:85386 )
• attenuated neutrophil and eosinophil infiltration of liver after ConA injection compared to controls

endocrine/exocrine glands
abnormal mammary gland growth during pregnancy ( J:124116 )
• mammary glands are normal in 5 week old virgin mice
• reduced side branches and alveolar buds at 5 days of gestation
• development continues to be delayed at 10 and 15 days of gestation
• density of lobuloalveolar structures is diminished: reduced 70% at 5 days, 50% at 10 days, 30% at 15 days

cellular
impaired eosinophil chemotaxis ( J:85386 )
• attenuated infiltration of liver after ConA injection compared to controls
impaired neutrophil chemotaxis ( J:85386 )
• attenuated infiltration of liver after ConA injection compared to controls

integument
abnormal mammary gland growth during pregnancy ( J:124116 )
• mammary glands are normal in 5 week old virgin mice
• reduced side branches and alveolar buds at 5 days of gestation
• development continues to be delayed at 10 and 15 days of gestation
• density of lobuloalveolar structures is diminished: reduced 70% at 5 days, 50% at 10 days, 30% at 15 days

reproductive system
abnormal mammary gland growth during pregnancy ( J:124116 )
• mammary glands are normal in 5 week old virgin mice
• reduced side branches and alveolar buds at 5 days of gestation
• development continues to be delayed at 10 and 15 days of gestation
• density of lobuloalveolar structures is diminished: reduced 70% at 5 days, 50% at 10 days, 30% at 15 days

hematopoietic system
impaired eosinophil chemotaxis ( J:85386 )
• attenuated infiltration of liver after ConA injection compared to controls
impaired neutrophil chemotaxis ( J:85386 )
• attenuated infiltration of liver after ConA injection compared to controls
abnormal macrophage physiology ( J:85386 )
• lessened macrophage death after ConA injection compared to controls




Genotype
MGI:5301102
hm6
Allelic
Composition		 Stat6tm1Gru/Stat6tm1Gru
Genetic
Background		 involves: 129S2/SvPas * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Stat6tm1Gru mutation (4 available); any Stat6 mutation (53 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
homeostasis/metabolism
decreased core body temperature ( J:178294 )
• Background Sensitivity: defects in cold induced thermogenesis




Genotype
MGI:3047086
cx7
Allelic
Composition		 Cd28tm1Mak/Cd28tm1Mak
Stat6tm1Gru/Stat6tm1Gru
Genetic
Background		 C.129S2(B6)-Cd28tm1Mak Stat6tm1Gru
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd28tm1Mak mutation (12 available); any Cd28 mutation (52 available)
Stat6tm1Gru mutation (4 available); any Stat6 mutation (53 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
increased susceptibility to parasitic infection ( J:90987 )
• Nippostrongylus brasiliensis fecundity was not depressed in experimental infections
• spontaneous Desmodex infections develop in 4-8 months
• severe dermatitis develops as a result of infection




Genotype
MGI:3697518
cx8
Allelic
Composition		 Foxp3tm1Tch/Y
Stat6tm1Gru/Stat6tm1Gru
Genetic
Background		 C.129-Stat6tm1Gru Foxp3tm1Tch
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Foxp3tm1Tch mutation (2 available); any Foxp3 mutation (58 available)
Stat6tm1Gru mutation (4 available); any Stat6 mutation (53 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
lethality at weaning, complete penetrance ( J:117165 )
• median survival is increased to 23 days; however the upper limit of survival span is not increased compared to Foxp3 single hemizygotes

immune system
immune system phenotype ( J:117165 )
N
• normalized levels of IgE
increased eosinophil cell number ( J:117165 )
• increased compared to wild-type but decreased compared to Foxp3 single hemizygotes
abnormal cytokine secretion ( J:117165 )
• profoundly impaired production of Th2 cytokines and enhanced production of Th1 cytokines

respiratory system
respiratory system phenotype ( J:117165 )
N
• goblet cell metaplasia in the lungs is absent

hematopoietic system
increased eosinophil cell number ( J:117165 )
• increased compared to wild-type but decreased compared to Foxp3 single hemizygotes

homeostasis/metabolism




Genotype
MGI:3818430
cx9
Allelic
Composition		 Il4tm1.1Wep/Il4+
Stat6tm1Gru/Stat6tm1Gru
Genetic
Background		 C.129-Stat6tm1Gru Il4tm1.1Wep
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Il4tm1.1Wep mutation (0 available); any Il4 mutation (46 available)
Stat6tm1Gru mutation (4 available); any Stat6 mutation (53 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal T-helper 2 cell differentiation ( J:138827 )
• CD4+ T cells fail to express IL-4 or GFP after in vitro activation under Th2 conditions and instead produce IFN-gamma (8%)
• these in vitro activated T cells also fail to upregulate mRNA encoding for IL-13, IL-5, IL-10, and GATA-3 proteins
• however, in vivo Th2 cell differentiation in response to a parasitic nematode infection is normal with Th2 cell numbers peaking at days 9-12 after primary infection and days 5-7 after secondary infection
• these Th2 cells upregulate mRNA encoding for IL-13, IL-5, and GATA-3 proteins
• normal in vivo Th2 cell differentiation is also observed in the Th2 priming models of allergic airway using either keyhole limpet hemocyanin or OVA sensitization, IgD neutralization, and intradermal ear injection of dead nematodes
impaired eosinophil recruitment ( J:138827 )
• eosinophil recruitment to the airways does not occur during infection with a parasitic nematode compared to controls which has a sizable migration for the first two weeks after primary and secondary infections
decreased IgE level ( J:138827 )
• serum IgE is absent 15 days after parasitic nematode infection compared to the 400 ng/ml present in controls
• serum IgE is also absent when the allergic airway model or the IgD neutralization model are induced

hematopoietic system
abnormal T-helper 2 cell differentiation ( J:138827 )
• CD4+ T cells fail to express IL-4 or GFP after in vitro activation under Th2 conditions and instead produce IFN-gamma (8%)
• these in vitro activated T cells also fail to upregulate mRNA encoding for IL-13, IL-5, IL-10, and GATA-3 proteins
• however, in vivo Th2 cell differentiation in response to a parasitic nematode infection is normal with Th2 cell numbers peaking at days 9-12 after primary infection and days 5-7 after secondary infection
• these Th2 cells upregulate mRNA encoding for IL-13, IL-5, and GATA-3 proteins
• normal in vivo Th2 cell differentiation is also observed in the Th2 priming models of allergic airway using either keyhole limpet hemocyanin or OVA sensitization, IgD neutralization, and intradermal ear injection of dead nematodes
impaired eosinophil recruitment ( J:138827 )
• eosinophil recruitment to the airways does not occur during infection with a parasitic nematode compared to controls which has a sizable migration for the first two weeks after primary and secondary infections
decreased IgE level ( J:138827 )
• serum IgE is absent 15 days after parasitic nematode infection compared to the 400 ng/ml present in controls
• serum IgE is also absent when the allergic airway model or the IgD neutralization model are induced




Genotype
MGI:3818431
cx10
Allelic
Composition		 Il4tm1.1Wep/Il4tm1.1Wep
Stat6tm1Gru/Stat6tm1Gru
Genetic
Background		 C.129-Stat6tm1Gru Il4tm1.1Wep
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Il4tm1.1Wep mutation (0 available); any Il4 mutation (46 available)
Stat6tm1Gru mutation (4 available); any Stat6 mutation (53 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
abnormal T-helper 2 cell differentiation ( J:138827 )
• CD4+ T cells fail to express IL-4 or GFP after in vitro activation under Th2 conditions
• these in vitro activated T cells also fail to upregulate mRNA encoding for IL-13, IL-5, IL-10, and GATA-3 proteins
• however, in vivo Th2 cell differentiation in response to a parasitic nematode infection is normal with Th2 cell numbers peaking at days 9-12 after primary infection and days 5-7 after secondary infection
• these Th2 cells upregulate mRNA encoding for IL-13, IL-5, and GATA-3 proteins
• normal in vivo Th2 cell differentiation is also observed in the Th2 priming models of allergic airway using either keyhole limpet hemocyanin or OVA sensitization, IgD neutralization, and intradermal ear injection of dead nematodes
impaired eosinophil recruitment ( J:138827 )
• eosinophil recruitment to the airways does not occur during infection with a parasitic nematode compared to controls which has a sizable migration for the first two weeks after primary and secondary infections
decreased IgE level ( J:138827 )
• serum IgE is absent 15 days after parasitic nematode infection compared to the 400 ng/ml present in controls
• serum IgE is also absent when the allergic airway model or the IgD neutralization model is induced

immune system
abnormal T-helper 2 cell differentiation ( J:138827 )
• CD4+ T cells fail to express IL-4 or GFP after in vitro activation under Th2 conditions
• these in vitro activated T cells also fail to upregulate mRNA encoding for IL-13, IL-5, IL-10, and GATA-3 proteins
• however, in vivo Th2 cell differentiation in response to a parasitic nematode infection is normal with Th2 cell numbers peaking at days 9-12 after primary infection and days 5-7 after secondary infection
• these Th2 cells upregulate mRNA encoding for IL-13, IL-5, and GATA-3 proteins
• normal in vivo Th2 cell differentiation is also observed in the Th2 priming models of allergic airway using either keyhole limpet hemocyanin or OVA sensitization, IgD neutralization, and intradermal ear injection of dead nematodes
impaired eosinophil recruitment ( J:138827 )
• eosinophil recruitment to the airways does not occur during infection with a parasitic nematode compared to controls which has a sizable migration for the first two weeks after primary and secondary infections
decreased IgE level ( J:138827 )
• serum IgE is absent 15 days after parasitic nematode infection compared to the 400 ng/ml present in controls
• serum IgE is also absent when the allergic airway model or the IgD neutralization model is induced




Genotype
MGI:5301099
cx11
Allelic
Composition		 Fbn1Tsk/Fbn1+
Stat6tm1Gru/Stat6tm1Gru
Genetic
Background		 involves: 129S2/SvPas * C57BL/10 * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fbn1Tsk mutation (2 available); any Fbn1 mutation (173 available)
Stat6tm1Gru mutation (4 available); any Stat6 mutation (53 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased interleukin-4 secretion ( J:57957 )
• no Il4 is produced by Th2 cells

integument
integument phenotype ( J:57957 )
N
• no skin fibrosis develops

respiratory system
emphysema ( J:57957 )
• emphysema develops as expected for heterozygous Fbn1Tsk




Genotype
MGI:3832413
cx12
Allelic
Composition		 Stat6tm1Gru/Stat6+
Tg(Scgb1a1-Il13)2Eli/?
Genetic
Background		 involves: 129S2/SvPas * C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Stat6tm1Gru mutation (4 available); any Stat6 mutation (53 available)
Tg(Scgb1a1-Il13)2Eli mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
respiratory system
abnormal respiratory system morphology ( J:132385 )
• substantial epithelial fibrosis occurs
abnormal lung morphology ( J:132385 )
• discolored lungs
abnormal lung size ( J:132385 )
• distended lungs
abnormal pulmonary alveolus morphology ( J:132385 )
• alveolar tissue destruction
overexpanded pulmonary alveolus ( J:132385 )
• alveoli are enlarged
abnormal respiratory system physiology ( J:132385 )
• develop airway hyper reactivity
• increased mucus production
respiratory system inflammation ( J:132385 )
• bronchoalveolar lavage contains increased numbers of macrophage, eosinophiles, lymphocytes, and neutrophiles

immune system
respiratory system inflammation ( J:132385 )
• bronchoalveolar lavage contains increased numbers of macrophage, eosinophiles, lymphocytes, and neutrophiles




Genotype
MGI:3832414
cx13
Allelic
Composition		 Stat6tm1Gru/Stat6tm1Gru
Tg(Scgb1a1-Il13)2Eli/?
Genetic
Background		 involves: 129S2/SvPas * C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Stat6tm1Gru mutation (4 available); any Stat6 mutation (53 available)
Tg(Scgb1a1-Il13)2Eli mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
respiratory system
respiratory system phenotype ( J:132385 )
N
• do not develop airway hyper reactivity
• normal mucus production
• no proinflamatory effects
• no airway epithelium fibrosis
• lung morphology normal




Genotype
MGI:3832416
cx14
Allelic
Composition		 Stat6tm1Gru/Stat6tm1Gru
Tg(Scgb1a1-Il13)2Eli/?
Tg(Scgb1a1-STAT6)1Erle/?
Genetic
Background		 involves: 129S2/SvPas * C57BL/6 * CBA * FVB
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Stat6tm1Gru mutation (4 available); any Stat6 mutation (53 available)
Tg(Scgb1a1-Il13)2Eli mutation (0 available)
Tg(Scgb1a1-STAT6)1Erle mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
respiratory system
respiratory system phenotype ( J:132385 )
N
• no proinflamatory effects
• no airway epithelium fibrosis
• lung morphology normal
abnormal respiratory system physiology ( J:132385 )
• develop airway hyper reactivity
• increased mucus production




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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory