All Phenotypes Chrna7<tm1Bay> MGI Mouse

Phenotypes associated with this allele

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Chrna7^tm1Bay/Chrna7^tm1Bay	B6.129S7-Chrna7^tm1Bay/J	MGI:3819267
hm2	Chrna7^tm1Bay/Chrna7^tm1Bay	B6.Cg-Chrna7^tm1Bay	MGI:3050969
hm3	Chrna7^tm1Bay/Chrna7^tm1Bay	involves: 129S7/SvEvBrd	MGI:4462395
hm4	Chrna7^tm1Bay/Chrna7^tm1Bay	involves: 129S7/SvEvBrd * C3H/HeN	MGI:5603931
hm5	Chrna7^tm1Bay/Chrna7^tm1Bay	involves: 129S7/SvEvBrd * C57BL/6	MGI:4950023
hm6	Chrna7^tm1Bay/Chrna7^tm1Bay	involves: 129S7/SvEvBrd * C57BL/6J	MGI:3050953
ht7	Chrna7^tm1Bay/Chrna7⁺	B6.129S7-Chrna7^tm1Bay/J	MGI:5603929
ht8	Chrna7^tm1Bay/Chrna7⁺	involves: 129S7/SvEvBrd * C3H/HeN	MGI:5603932
cx9	Chrna3^tm1.1Hwrt/Chrna3^tm1.1Hwrt Chrna7^tm1Bay/Chrna7^tm1Bay	involves: 129S1/Sv * 129S7/SvEvBrd * C57BL/6	MGI:4442219
cx10	Agrn^tm4Jrs/Agrn^tm4Jrs Chrna1^tm1Klee/Chrna1^tm1Klee Chrna7^tm1Bay/Chrna7^tm1Bay	involves: 129S4/SvJae * 129S7/SvEvBrd * C57BL/6	MGI:4462396
cx11	Chrna7^tm1Bay/Chrna7^tm1Bay Chrnb2^tm1Mdb/Chrnb2^tm1Mdb	involves: 129S7/SvEvBrd * C57BL/6J	MGI:4822560

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

reproductive system

reproductive system phenotype ( J:92540 , J:115434 )

• female homozygotes have normal ovaries and enter puberty at the expected age, with no significant differences in the onset of vaginal opening or cornification relative to wild-type or heterozygous control females (J:92540)

• male homozygotes are fertile and exhibit an apparently normal mating behavior (J:92540)

• testicular weight, total sperm number, and sperm morphology appear normal (J:115434)

asthenozoospermia ( J:115434 )

• mutant sperm initially appear to swim normally but fail to maintain progressive forward motility

• only few mutant sperm retain rapid swimming velocities and display hyperactivated swimming patterns following in vitro capacitation

• many nonmotile sperm exhibit a quivering head and midpiece but no forward movement, confirming that cells are alive

• however, no significant differences in sperm viability, senescence rate or spontaneous acrosome reaction rate are observed between mutant and wild-type sperm before and after capacitation

prolonged estrous cycle ( J:92540 )

• female homozygotes show asynchronous, prolonged estrous cycles, with an average cycle length of 7.1 0.68 days relative to wild-type and heterozygous females (4.3 0.19 and 4.3 0.10 days, respectively)

• the extent of asynchrony is variable within the mutant female population, but for a given animal, the average cycle length tends to remain stable at young mature ages (4-6 months) and middle ages (10-14 months)

• all female homozygotes eventually complete an estrous cycle, and may achieve pregnancy but with a smaller number of surviving pups

reduced female fertility ( J:92540 )

• the number of live births is significantly less from matings of female homozygotes with either heterozygous (4.5 2.12) or homozygous (3.7 0.53) mutant males in comparison to matings of heterozygous females and males (7.34 0.04) and matings of heterozygous females and homozygous mutant males (7.1 0.40)

decreased litter size ( J:92540 )

• litters born to homozygous mutant females are significantly smaller than those born to heterozygous females regardless of the male genotype

nervous system

abnormal brain interneuron morphology ( J:214099 )

• development of parvalbumin-positive GABAergic interneurons is disrupted in cortical cultures

• NMDA receptor expression is reduced in cortical GABAergic interneurons of cortical cultures

• development and maturation of cortical parvalbumin-positive basket cells is impaired in cortical cultures

• parvalbumin and GAD67 levels are reduced in the soma of parvalbumin-positive GABAergic interneurons

• GABAAalpha1 levels are reduced in parvalbumin-positive GABAergic interneurons in the prefrontal cortex

abnormal cerebral cortex morphology ( J:214099 )

• cortical levels of GABAergic makers (parvalbumin, glutamic acid decarboxylase 65/67 (GAD65/67) and the alpha1 subunit of GABAA receptors) are decreased during late postnatal development and adulthood

abnormal cerebral cortex pyramidal cell morphology ( J:214099 )

• GABAAalpha1 levels are reduced in pyramidal neurons of the prefrontal cortex

decreased CNS synapse formation ( J:214099 )

• marker analysis indicates that cortical GABAergic synapse formation is impaired in prefrontal cortex and in cortical cultures

• formation of parvalbumin- and GAD65-positive perisomatic synapses is impaired in cortical cultures

abnormal GABAergic neuron morphology ( J:214099 )

• levels of markers of GABAergic maturation are reduced in the neocortex indicating that cortical parvalbumin GABAergic development is impaired

abnormal GABAergic neuron physiology ( J:214099 )

• cortical GABAergic synaptic defects in the prefrontal cortex and in cortical cultures

abnormal GABA-mediated receptor currents ( J:214099 )

• cultured cortical pyramidal neurons show a reduction in sIPSC frequency and current decay time, but not amplitude, indicating reduced GABAergic neurotransmission

behavior/neurological

impaired spatial working memory ( J:123663 )

• in the delayed matching-to-place task of the Morris water maze, mutants take longer to find the hidden platform than controls, indicating a minor impairment in working/episodic memory

• however, mice show normal latency to enter the central zone of the open field, normal elevated plus maze behavior, and no differences in swim speed or thigmotaxic behavior

taste/olfaction

impaired olfaction ( J:166638 )

• mice exhibit deficits in detecting or discriminating chemically-related odors

cellular

asthenozoospermia ( J:115434 )

• mutant sperm initially appear to swim normally but fail to maintain progressive forward motility

• only few mutant sperm retain rapid swimming velocities and display hyperactivated swimming patterns following in vitro capacitation

• many nonmotile sperm exhibit a quivering head and midpiece but no forward movement, confirming that cells are alive

• however, no significant differences in sperm viability, senescence rate or spontaneous acrosome reaction rate are observed between mutant and wild-type sperm before and after capacitation

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
schizophrenia		DOID:5419	OMIM:181500	J:214099

Allelic Composition	Chrna7^tm1Bay/Chrna7^tm1Bay
Genetic Background	B6.Cg-Chrna7^tm1Bay

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Chrna7^tm1Bay mutation (1 available); any Chrna7 mutation (50 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

behavior/neurological phenotype ( J:51149 )

• homozygotes exhibit normal base-line learning and memory performance, and normal sensorimotor gating relative to wild-type

• also, homozygotes are behaviorally similar to wild-type mice in a wide variety of behavioral tests

• significant gender differences are noted in several tests; however, there is no evidence suggesting that these gender differences are genotype-specific

abnormal seizure response to pharmacological agent ( J:74703 )

• homozygotes and wild-type mice display a similar dose-response curve for nicotine-elicited clonic-tonic seizures

• neither cholinergic compensatory mechanisms nor alterations in binding levels or affinity for nicotinic ligands, such as epibatidine or nicotine, can account for the retained sensitivity to the convulsant effects of nicotine

abnormal spatial learning ( J:51149 )

• homozygotes locate the hidden platform in the Morris water task significantly faster than wild-type; however, this is a subtle difference and is not supported by the distance traveled data

• also, homozygotes and wild-type mice show a comparable search behavior during the probe trials

decreased anxiety-related response ( J:51149 )

• homozygotes spend a significantly greater proportion of their total distance traveled in the open field in the center of the arena relative to wild-type

• however, this difference in altered anxiety-related behavioral response is not corroborated by the light<->dark exploration test

immune system

abnormal interleukin level ( J:89610 )

• endotoxemic homozygotes produce significantly higher levels of IL-1 and IL-6

abnormal tumor necrosis factor level ( J:89610 )

• following endotoxin administration, homozygotes show significantly higher levels of serum TNF levels as well as higher TNF production in the liver and spleen relative to wild-type

• mutant macrophages are refractory to cholinergic agonists and generate TNF normally in the presence of nicotine or acetylcholine

• electrical stimulation of the vagus nerve inhibits endotoxin-induced serum TNF levels in wild-type mice, but fails to reduce serum TNF levels in endotoxemic homozygotes

nervous system

abnormal seizure response to pharmacological agent ( J:74703 )

• homozygotes and wild-type mice display a similar dose-response curve for nicotine-elicited clonic-tonic seizures

homeostasis/metabolism

abnormal interleukin level ( J:89610 )

• endotoxemic homozygotes produce significantly higher levels of IL-1 and IL-6

abnormal tumor necrosis factor level ( J:89610 )

• following endotoxin administration, homozygotes show significantly higher levels of serum TNF levels as well as higher TNF production in the liver and spleen relative to wild-type

• mutant macrophages are refractory to cholinergic agonists and generate TNF normally in the presence of nicotine or acetylcholine

• electrical stimulation of the vagus nerve inhibits endotoxin-induced serum TNF levels in wild-type mice, but fails to reduce serum TNF levels in endotoxemic homozygotes

Allelic Composition	Chrna7^tm1Bay/Chrna7^tm1Bay
Genetic Background	involves: 129S7/SvEvBrd

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Chrna7^tm1Bay mutation (1 available); any Chrna7 mutation (50 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

failure of neuromuscular synapse presynaptic differentiation ( J:161300 )

Allelic Composition	Chrna7^tm1Bay/Chrna7^tm1Bay
Genetic Background	involves: 129S7/SvEvBrd * C3H/HeN

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Chrna7^tm1Bay mutation (1 available); any Chrna7 mutation (50 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

taste/olfaction

impaired olfaction ( J:166638 )

• mice exhibit deficits in detecting or discriminating chemically-related odors

Allelic Composition	Chrna7^tm1Bay/Chrna7^tm1Bay
Genetic Background	involves: 129S7/SvEvBrd * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Chrna7^tm1Bay mutation (1 available); any Chrna7 mutation (50 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

respiratory system

abnormal airway basal cell differentiation ( J:154705 )

• after polidocanol-induced acute injury, 8-wk old mutant mice display delayed regeneration of the tracheal epithelium with a transient hyperplasia of basal cells observed on days 4 and 6, but not on day 8, after injury

airway basal cell hyperplasia ( J:154705 )

• at 1 year of age, the % of 1-2 layers of basal cells in the tracheal epithelium is reduced whereas the % of 3-4 layers of basal cells in increased by 3.8-fold relative to that in wild-type controls

cellular

abnormal airway basal cell differentiation ( J:154705 )

immune system

immune system phenotype ( J:103908 )

N	• IgM levels of preimmune serum are little altered from control levels

decreased immunoglobulin level ( J:103908 )

• significantly reduced preimmune serum Ig levels

decreased IgG level ( J:103908 )

hematopoietic system

decreased immunoglobulin level ( J:103908 )

• significantly reduced preimmune serum Ig levels

decreased IgG level ( J:103908 )

Allelic Composition	Chrna7^tm1Bay/Chrna7^tm1Bay
Genetic Background	involves: 129S7/SvEvBrd * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Chrna7^tm1Bay mutation (1 available); any Chrna7 mutation (50 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

nervous system phenotype ( J:44288 )

N	• homozygotes display normal growth, survival, gait, and anatomy and show no developmental abnormalities in the nervous system

abnormal brain morphology ( J:44288 )

• homozygotes lack high-affinity [125I]alpha-bungarotoxin binding sites

• however, autoradiography with [3H]nicotine revealed normal levels of high-affinity nicotine binding

abnormal nicotine-mediated receptor currents ( J:44288 )

• hippocampal neurons from mutant mice do not exhibit rapidly desensitizing, methyllycaconitine-sensitive nicotinic currents

reproductive system

reduced fertility ( J:44288 )

• homozygotes do not breed well

hematopoietic system

abnormal myeloblast morphology/development ( J:140280 )

• fewer myeloblasts and metamyeloblasts in bone marrow

decreased erythroblast number ( J:140280 )

• fewer erythroblasts and pro-normoblasts found in bone marrow

decreased neutrophil cell number ( J:140280 )

• fewer band neutrophils in bone marrow

increased lymphocyte cell number ( J:140280 )

• increased lymphocytes in bone marrow

immune system

decreased neutrophil cell number ( J:140280 )

• fewer band neutrophils in bone marrow

increased lymphocyte cell number ( J:140280 )

• increased lymphocytes in bone marrow

Allelic Composition	Chrna7^tm1Bay/Chrna7⁺
Genetic Background	B6.129S7-Chrna7^tm1Bay/J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Chrna7^tm1Bay mutation (1 available); any Chrna7 mutation (50 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

taste/olfaction

impaired olfaction ( J:166638 )

• mice exhibit deficits in detecting or discriminating chemically-related odors

Allelic Composition	Chrna7^tm1Bay/Chrna7⁺
Genetic Background	involves: 129S7/SvEvBrd * C3H/HeN

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Chrna7^tm1Bay mutation (1 available); any Chrna7 mutation (50 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

taste/olfaction

impaired olfaction ( J:166638 )

• mice exhibit deficits in detecting or discriminating chemically-related odors

Allelic Composition	Chrna3^tm1.1Hwrt/Chrna3^tm1.1Hwrt Chrna7^tm1Bay/Chrna7^tm1Bay
Genetic Background	involves: 129S1/Sv * 129S7/SvEvBrd * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Chrna3^tm1.1Hwrt mutation (1 available); any Chrna3 mutation (35 available)
Chrna7^tm1Bay mutation (1 available); any Chrna7 mutation (50 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

abnormal excitatory postsynaptic potential ( J:157611 )

• most nerve-evoked excitatory postpynaptic potentials (EPSPs) on sympathetic neurons in the superior cervical ganglia are subthreshold compared to in wild-type mice

• unlike in wild-type mice, nerve evoked EPSPs are blocked by alpha-bungarotoxin

Allelic Composition	Agrn^tm4Jrs/Agrn^tm4Jrs Chrna1^tm1Klee/Chrna1^tm1Klee Chrna7^tm1Bay/Chrna7^tm1Bay
Genetic Background	involves: 129S4/SvJae * 129S7/SvEvBrd * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Agrn^tm4Jrs mutation (0 available); any Agrn mutation (102 available)
Chrna1^tm1Klee mutation (0 available); any Chrna1 mutation (17 available)
Chrna7^tm1Bay mutation (1 available); any Chrna7 mutation (50 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

failure of neuromuscular synapse presynaptic differentiation ( J:161300 )

Allelic Composition	Chrna7^tm1Bay/Chrna7^tm1Bay Chrnb2^tm1Mdb/Chrnb2^tm1Mdb
Genetic Background	involves: 129S7/SvEvBrd * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Chrna7^tm1Bay mutation (1 available); any Chrna7 mutation (50 available)
Chrnb2^tm1Mdb mutation (1 available); any Chrnb2 mutation (32 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

behavior/neurological phenotype ( J:94667 )

• mutant and control mice have similar rates of locomotor movement in the open field test; they also display similar levels of exploration of the "anxiety-provoking" area of the open-field indicating that both genotypes show similar anxiety-related responses

• vertical movement, i.e. rearing behavior, is also not significantly different between mutant and control mice

• no differences in prepulse inhibition of the acoustic startle response are detected between mutant and control mice

impaired passive avoidance behavior ( J:94667 )

• compared to controls, mutant mice show significantly decreased latencies to enter the dark side of a light/dark box in a passive avoidance test after an initial shock on the dark side; an increase in shock intensity did not alter the results significantly suggesting that mutant mice do not have a decreased sensitivity to the shock

decreased anxiety-related response ( J:94667 )

• in contrast to the open field test, mutant mice show significantly more light-dark transitions in a light/dark crossing task compared with the controls, suggesting decreased anxiety; however, the latency to enter the dark side is similar to controls

enhanced coordination ( J:94667 )

• in a rotarod test, mutant mice spend more time walking on top of the rotating rod after training than controls

hyperactivity ( J:94667 )

• authors report that mice appear hyperactive, but the result is not statistically significant

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