Analysis Tools|
Allele Symbol Allele Name Allele ID |
Lmx1adr-J dreher Jackson MGI:1888413 |
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| Summary |
7 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• Background Sensitivity: shorter life span than wild-type in original mixed background
• Background Sensitivity: in C57BL/6 background, no live-born homozygotes are generated
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• preweaning mortality is high
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• a tiny filament at the tip of the tail seen at birth disappears by 2 days after birth leaving either a short tail or distinctly blunted tail
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• a delayed development of the righting reflex
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• white belly spot and feet
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• white belly spot and feet
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• Background Sensitivity: shorter life span than wild-type in original mixed background
• Background Sensitivity: initial breeding experiments in mixed background generated many live born homozygous pups
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• a complete white belt around trunk with some variability
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• abnormal neuronal migration contributes to abnormal cerebellum development
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• in vertebrae T9-T13
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• significant changes in the shape of rhombomeres 3, 4, and 5 are observed in homozygote embryos
• however, hindbrain segmentation and territories posterior to r6 are not affected
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• r3 is deformed and bends posteriorly
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• the dorsal/lateral domains of r4 are compressed or reduced in width
• however, the ventral region of r4 is normal, as shown by proper migration of the facial motor neurone population along the midline into r5
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• r5 is broadened and not separated at the midline into two bilateral domains as seen in wild-type embryos
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• defective roof plate formation in the hindbrain
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• pyramidal layer forms widely dispersed arrangements in this area
• there is aberrant cholinergic activity
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• forms widely dispersed arrangements in CA3 region
• there are ectopically located pyramidal cells in the stratum radiatum and stratum oriens
• abnormal acetylcholinesterase activity is found in the ectopic pyramidal cells
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• the cerebellum is almost completely absent
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• disruptions in foliation are found
• there are mixtures of normal and abnormal laminated structure
• islands of both granule and Purkinje cells or just granule cells are observed
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• much reduced glossopharyngeal ganglion
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• an accessory branch originating in the glossopharyngeal/vagus region projects abnormally
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• the shape and ossification is severely disrupted
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• the shape of the parietal bone is affected
• highly disorganized lamboid suture
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• the shape and ossification is severely disrupted
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• the shape of the parietal bone is affected
• highly disorganized lamboid suture
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• neural arches in C1 fail to form along the dorsal midline
• delay in fusion of the arches in C2 and C3
• failure in dorsal fusion of vertebrae T9-T13 causing grossly altered neural arches
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• occasional synostosis of the cranial vault along the interface of the interparietal and supraoccipital bone
• responsible for the blebbing on the head seen in live animals
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• an abnormal distribution of acetylcholinesterase is found in the hippocampus
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• abnormal neuronal migration contributes to abnormal cerebellum development
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• disruption of cell proliferation contributes to abnormal cerebellum development
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• in vertebrae T9-T13
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• significant changes in the shape of rhombomeres 3, 4, and 5 are observed in homozygote embryos
• however, hindbrain segmentation and territories posterior to r6 are not affected
|
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• r3 is deformed and bends posteriorly
|
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• the dorsal/lateral domains of r4 are compressed or reduced in width
• however, the ventral region of r4 is normal, as shown by proper migration of the facial motor neurone population along the midline into r5
|
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• r5 is broadened and not separated at the midline into two bilateral domains as seen in wild-type embryos
|
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• defective roof plate formation in the hindbrain
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• a complete white belt around trunk with some variability
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• at E12.5, reduced proliferation is observed in the cerebellar anlage
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• Background Sensitivity: in C57BL/6 background, a white patch of variable size in the coat on the belly
• Background Sensitivity: in C57BL/6 background, white spotting trait became fully penetrant
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• Background Sensitivity: in C57BL/6 background, a white patch of variable size in the coat on the belly
• Background Sensitivity: in C57BL/6 background, white spotting trait became fully penetrant
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• fourth ventricle roof plate size is dramatically smaller relative to wild-type or Lmx1a-null mice at E10.5
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• P20 mice show severe cerebellar defects
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• at E12.5, reduced proliferation is observed in the cerebellar anlage
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• cerebellum is reduced in size
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 12/17/2024 MGI 6.24 |
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