All Phenotypes Lhx9<tm1Lmgd> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Lhx9^tm1Lmgd
targeted mutation 1, Laboratory of Mammalian Genes and Development, Heiner Westphal
MGI:1888554

Summary

1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Lhx9^tm1Lmgd/Lhx9^tm1Lmgd	involves: 129S1/Sv * 129X1/SvJ * C57BL/6	MGI:2181825

Allelic Composition	Lhx9^tm1Lmgd/Lhx9^tm1Lmgd
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lhx9^tm1Lmgd mutation (2 available); any Lhx9 mutation (31 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

endocrine/exocrine glands

agonadal ( J:60621 )

• all mice lacked gonads; at E13.5, no gonads are apparent

absent ovary ( J:60621 )

absent testes ( J:60621 )

homeostasis/metabolism

decreased circulating testosterone level ( J:60621 )

• undetectable levels of testosterone

decreased circulating estradiol level ( J:60621 )

• undetectable levels of estradiol

increased circulating follicle stimulating hormone level ( J:60621 )

• elevated levels of FSH

reproductive system

decreased primordial germ cell proliferation ( J:60621 )

• primordial germ cells migrate to the gonadal region at E12.0, but the proliferation of gonadal cells at E11.5 was not apparent

abnormal female reproductive system morphology ( J:60621 )

• atrophic

uterus atrophy ( J:60621 )

vagina atrophy ( J:60621 )

abnormal male reproductive system morphology ( J:60621 )

• no male accessory sex organs found in genetically identified males

abnormal primary sex determination ( J:60621 )

• all mice phenotypically female, although half were genetically male

agonadal ( J:60621 )

• all mice lacked gonads; at E13.5, no gonads are apparent

absent ovary ( J:60621 )

absent testes ( J:60621 )

secondary sex reversal ( J:60621 )

• all mice phenotypically female, although half were genetically male

• no male accessory sex organs found in genetically identified males

absent estrous cycle ( J:60621 )

• females did not undergo an oestrus cycle

infertility ( J:60621 )

• mice were infertile

female infertility ( J:60621 )

male infertility ( J:60621 )

cellular

decreased primordial germ cell proliferation ( J:60621 )

• primordial germ cells migrate to the gonadal region at E12.0, but the proliferation of gonadal cells at E11.5 was not apparent

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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