Phenotypes associated with this allele

• Allele Symbol: Mfrp^rd6
• Allele Name: retinal degeneration 6
• Allele ID: MGI:1888705
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Mfrp^rd6/Mfrp^rd6	B6.C3-Mfrp^rd6	MGI:2386344
hm2	Mfrp^rd6/Mfrp^rd6	involves: C3HfB6/Anl	MGI:5312661

Genotype
MGI:2386344

hm1

• Allelic Composition: Mfrp^rd6/Mfrp^rd6
• Genetic Background: B6.C3-Mfrp^rd6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

vision/eye

retina photoreceptor degeneration ( J:64087 )

• progressive degeneration of rods and cones as detected by electroretinogram; age of onset is approximately 1 month

retina degeneration ( J:64087 )

• age of onset is approximately 7 months

retina spots ( J:64087 )

• subretinal spots oriented in a regular pattern across the retina are apparent by ophthalmoscopic examination at approximately 8-10 weeks of age

nervous system

retina photoreceptor degeneration ( J:64087 )

• progressive degeneration of rods and cones as detected by electroretinogram; age of onset is approximately 1 month

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
fundus albipunctatus		DOID:11105	OMIM:136880	J:64087

Genotype
MGI:5312661

hm2

• Allelic Composition: Mfrp^rd6/Mfrp^rd6
• Genetic Background: involves: C3HfB6/Anl

vision/eye

vision/eye phenotype ( J:181596 )

N • retinal pigment epithelium phagocytosis is normal

abnormal retina pigment epithelium morphology ( J:181596 )

• mice exhibit an increase in the number of apical microvilli compared with wild-type mice

pigmentation

abnormal retina pigment epithelium morphology ( J:181596 )

• mice exhibit an increase in the number of apical microvilli compared with wild-type mice