Phenotypes associated with this allele

• Allele Symbol: Ndst1^tm1Ekf
• Allele Name: targeted mutation 1, Erik Forsberg
• Allele ID: MGI:1888706
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Ndst1^tm1Ekf/Ndst1^tm1Ekf	involves: 129S1/Sv * 129X1/SvJ * C57BL/6	MGI:3587786

Genotype
MGI:3587786

hm1

• Allelic Composition: Ndst1^tm1Ekf/Ndst1^tm1Ekf
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Newborn Ndst1^tm1Ekf/Ndst1^tm1Ekf mice display lung atelectasia

mortality/aging

neonatal lethality, complete penetrance ( J:63996 )

• pups cyanotic and died neonatally

lethality throughout fetal growth and development, incomplete penetrance ( J:63996 )

• some death between E14.5 and E18.5

respiratory system

atelectasis ( J:63996 )

• lungs fail to inflate at birth

respiratory failure ( J:63996 )

abnormal surfactant secretion ( J:63996 )

• less secreted surfactant protein but produced by more cells

homeostasis/metabolism

cyanosis ( J:63996 )

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
newborn respiratory distress syndrome		DOID:12716	OMIM:267450	J:63996