Phenotypes associated with this allele

• Allele Symbol: Timp2^tm1Pds
• Allele Name: targeted mutation 1, Paul D Soloway
• Allele ID: MGI:1888708
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Timp2^tm1Pds/Timp2^tm1Pds	B6.129S4-Timp2^tm1Pds	MGI:3665128
hm2	Timp2^tm1Pds/Timp2^tm1Pds	involves: 129S4/SvJae * C57BL/6	MGI:3664798

Genotype
MGI:3665128

hm1

• Allelic Composition: Timp2^tm1Pds/Timp2^tm1Pds
• Genetic Background: B6.129S4-Timp2^tm1Pds

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

abnormal cued conditioning behavior ( J:99752 )

• null mice have a deficit in fear-potentiated startle (FPS) vs wild-type; mice generate greater startle responses compared to wild-type mice in presence of tone before fear conditioning (ie. P0 - first testing session)

• all males show an increase in FPS initially (from P0 to P1) but FPS decreases from that point in knockout and knockdown mice; in wild-type and heterozygotes, amplitudes of startle responses continue to increase

• wild-type and heterozygous males acquire conditioned fear over the course of the test, but null and knockdown mice do not

• females do not show any proportional increases in FPS

nervous system

decreased prepulse inhibition ( J:99752 )

• Timp2-null mice have significantly reduced prepulse inhibition (PPI)

Genotype
MGI:3664798

hm2

• Allelic Composition: Timp2^tm1Pds/Timp2^tm1Pds
• Genetic Background: involves: 129S4/SvJae * C57BL/6

hematopoietic system

increased neutrophil cell number ( J:112941 )

• at day 7 after treatment, BAL neutrophil percentage and concentration are 3- and 10-fold higher in Timp1-null mice compared to Timp2-null animals; values for Timp2-null mice are similar to wild-type

immune system

increased neutrophil cell number ( J:112941 )

• at day 7 after treatment, BAL neutrophil percentage and concentration are 3- and 10-fold higher in Timp1-null mice compared to Timp2-null animals; values for Timp2-null mice are similar to wild-type

homeostasis/metabolism

abnormal enzyme/coenzyme activity ( J:64001 )

• activation of proMMP-2 in vivo is dramatically altered with Timp2 deficiency

cardiovascular system

cardiovascular system phenotype ( J:211441 )

N • following angiotensin II infusion, mice exhibit a normal increase in blood pressure and normal heart rate