Phenotypes associated with this allele

• Allele Symbol: Timp2^tm1Jjc
• Allele Name: targeted mutation 1, John J Caterina
• Allele ID: MGI:1888709
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Timp2^tm1Jjc/Timp2^tm1Jjc	B6.129P2-Timp2^tm1Jjc	MGI:3664801
hm2	Timp2^tm1Jjc/Timp2^tm1Jjc	involves: 129P2/OlaHsd * C57BL/6	MGI:3664803

Genotype
MGI:3664801

hm1

• Allelic Composition: Timp2^tm1Jjc/Timp2^tm1Jjc
• Genetic Background: B6.129P2-Timp2^tm1Jjc

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

abnormal cued conditioning behavior ( J:99752 )

• male Timp2^tm1Jjc homozygotes (knockdown mice) show lower fear-potentiated startle (FPS) than male Timp2^tm1Pds homozygotes (knockouts)

• all males show an increase in FPS initially (from P0 to P1) but FPS decreases from that point in knockout and knockdown mice; in wild-type and heterozygotes, amplitudes of startle responses continue to increase

• wild-type and heterozygous males acquire conditioned fear over the course of the test, but null and knockdown mice do not

• females do not show any proportional increases in FPS

nervous system

abnormal prepulse inhibition ( J:99752 )

• knockdown mice show similar PPI to wild-type

Genotype
MGI:3664803

hm2

• Allelic Composition: Timp2^tm1Jjc/Timp2^tm1Jjc
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

homeostasis/metabolism

abnormal enzyme/coenzyme level ( J:64002 )

• Timp2 deficiency dramatically alters activation of proMMP-2 in vivo in animals

normal phenotype

no abnormal phenotype detected ( J:64002 )

• mice appear viable, fertile and overtly normal in appearance; detailed analysis beyond molecular phenotype not presented